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Specialty: Neurology
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Total 137 results found since Jan 2013.

TIA Biomarkers Determined Through Proteomics (I11-1A)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: The Promise of Novel Biomarker Approaches in Advancing Treatment Data Blitz Presentations Source Type: research

TIA Biomarkers Determined Through Proteomics (S30.002)
Conclusions: PBP has been identified as potential serum biomarker for TIA. Larger sample size may find that ceruloplasmin is an additional candidate. Ultimately, a panel of proteins may be required. Larger studies are needed to determine the validity of these proteins in clinical use.Disclosure: Dr. George has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Kuo has nothing to disclose. Dr. Kemp has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Albers has received personal compensation for activities with Genentech, Inc. and Lundbeck Research USA, Inc. as an ad...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Mlynash, M., Adams, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research

Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam. Introduction Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Mapping dysfunctional connectivity in brain injury (P02.267)
Structural brain imaging tools fail to detect pathological changes to brain function in the absence of observable structural damage. Identifying areas of dysfunction in brain injury patients could lead to more sensitive and better targeted therapy. This manuscript proposes a novel methodology for using resting state functional connectivity MRI (fcMRI) to identify dysfunctional cortex. The method compares patterns of connectivity within a patient's brain to those in normal control individuals and identifies areas of the individual's brain from which connectivity is abnormal. I present a patient diagnosed with abulia followi...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Siegel, J. Tags: P02 Medical Student Essay Award Recipients Source Type: research

Identifying Novel Biomarkers of Cerebral Ischemia through the Use of Mass Spectroscopy (S15.004)
CONCLUSIONS: Mass spectroscopy-based proteomics is a potential new tool to help identify biomarkers for cerebral ischemia. Ultimately, a panel of proteins may serve as a marker for cerebral ischemia or TIA. We have identified three candidate proteins as possible indicators for cerebral ischemia. Larger studies are needed to confirm our results. Study Supported by: Stanford Cardiovascular Institute; American Brain Foundation and American Academy of Neurology Clinical Research Training FellowshipDisclosure: Dr. George has nothing to disclose. Dr. Adams has nothing to disclose. Dr. Mlynash has nothing to disclose. Dr. Kjaerga...
Source: Neurology - April 9, 2014 Category: Neurology Authors: George, P., Adams, C., Mlynash, M., Kjaergaard, C., Kuo, C., Kemp, S., Garcia, M., Albers, G., Olivot, J.-M. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical and Imaging Biomarkers and Genetics Source Type: research

Neurologic Complications of Extracorporeal Membrane Oxygenation.
CONCLUSIONS: Given the increasing utilization of ECMO and the high costs and poor outcomes associated with neurologic complications, more research is needed to help determine the best way to prevent these sequelae in this patient population. PMID: 26320848 [PubMed - as supplied by publisher]
Source: Journal of Clinical Neurology - September 1, 2015 Category: Neurology Tags: J Clin Neurol Source Type: research

Safety and Efficacy of IV-tPA Use in Patients 80 Years and Older- A Retrospective Review (P2.305)
Conclusion—We observed no increase in sICH post IV-tPA in patients 80+ when compared to those younger. Higher mortality in those 80+ likely due to baseline disabilities. Within the 80+ group, predictors of mortality and poor outcomes included disabilities prior to hospitalization, prior stroke/TIA, higher NIHSS at admission, sICH post treatment and higher diastolic blood pressure.Disclosure: Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Kwan has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Babikian has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Lau, H., Romero, J., Kwan, S., Kase, C., Babikian, V. Tags: Acute Therapy: IV t-PA Source Type: research

Age Is a Greater Influence on Small Saccades Than Target Size in Normal Subjects on the Horizontal Video Head Impulse Test
Conclusion: While this study suggests that target size may have a statistically significant impact on the vHIT saccade profile of normal subjects, age has a greater influence on the incidence and size of small vHIT saccades. Introduction The video head impulse test (vHIT) is a quantitative adaptation of the clinical head impulse test (1), and enables functional assessment of the high-frequency angular vestibulo-ocular reflex (VOR) in all three planes of head rotation (2, 3). Lightweight goggles worn by the subject detect head movement using an accelerometer and gyroscope, and a high frame rate video camera tracks eye...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Hemodynamic Characteristics Associated With Paraclinoid Aneurysm Recurrence in Patients After Embolization
Conclusions: High peak systolic WSS, OSI and velocity around aneurysm neck areas after embolization of paraclinoidal aneurysms may be important factors leading to recurrence. Introduction Paraclinoid aneurysms are defined as aneurysms arising from the segment of the internal carotid artery (ICA) between the distal dural ring and the origin of the posterior communicating artery. They account for approximately 1.3–5% of all intracranial aneurysms and they comprise the majority of such aneurysms in females (1–3). Hemodynamic characteristics are thought to be the most important risk factors for occurrence...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Familiarity with visual forms contributes to a left-lateralized and increased N170 response for Chinese characters
Publication date: Available online 19 September 2019Source: NeuropsychologiaAuthor(s): Licheng Xue, Urs Maurer, Xuchu Weng, Jing ZhaoAbstractWhile skilled readers produce an increased and left-lateralized event-related-potential (ERP) component, known as N170, for strings of letters compared to strings of less familiar units, it remains unclear whether perceptual familiarity plays an important role in driving increased and left-lateralized N170 for print. The present study addressed this issue by examining N170 responses for regular Chinese characters and cursive Chinese characters which are visually less familiar regardin...
Source: Neuropsychologia - September 20, 2019 Category: Neurology Source Type: research

Adverse Events with Implantable Deep Brain Stimulators - Trends and Insight from the FDA MAUDE Database, 2001 - 2007 (P02.074)
CONCLUSIONS: The frequency of AEs with DBS devices increased dramatically between 2001 and 2007. Within the accepted limitations of a voluntary database, infection and device malfunction are common AEs and often lead to explantation. More serious events such as death or stroke are uncommon. This study includes larger numbers of AEs than prior published reports and reinforces the need for device registries for long-term safety evaluation.Disclosure: Dr. Diaz has nothing to disclose. Dr. McMurtray has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Diaz, N., McMurtray, A. Tags: P02 Movement Disorders: Dystonia Source Type: research

Blacks Are Less Likely To Be Admitted with Transient Ischemic Attack Than Whites in the Bronx (P03.197)
CONCLUSIONS: The TIA-IS ratio differs by age, gender and race, raising the question of whether some groups are less likely to be admitted with TIA than others. We suspect that the differences are related to physician and patient behavior. In particular, blacks, particularly black men, may be less likely to obtain emergency care for TIA symptoms than whites or Hispanics. If confirmed, this finding would support targeting resources for public education on TIA to black Americans.Disclosure: Dr. Bhupali has nothing to disclose. Dr. Labovitz has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bhupali, D., Labovitz, D. Tags: P03 Cerebrovascular Disease III Source Type: research

Taking Neurology to the Underserved - A Pilot Initiative in an Urban Homebound Program (P6.007)
CONCLUSIONS: Our pilot program highlights types of chronic neurologic illnesses afflicting the homebound population, treatment interventions utilized, and clinical challenges encountered. By considering the real-world intersection of disease and living environment, trainees gained perspective on the debilitating impact of neurological illness on homebound patients. This pilot program reveals the need and feasibility of neurological home based care as an important clinical, educational, and palliative paradigm.Disclosure: Dr. Ramdhani has nothing to disclose. Dr. Fabian has received personal compensation for activities with...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ramdhani, R., Fabian, M., Wajnberg, A., DeCherrie, L., Krieger, S. Tags: General Neurology V Source Type: research

Detection of Symptomatic Carotid Plaque Using Source Data from MR and CT Angiography: A Correlative Study
Background: Carotid plaque MRI has been a useful method to characterize vulnerable atherosclerotic plaque elements. Recent investigations have suggested that source images from CT angiography (CTA) and MR angiography (MRA) can identify the simple high-risk features of symptom-producing carotid artery plaque. We studied the correlation and relative diagnostic accuracies of CTA and MRA source images in detecting symptomatic carotid artery plaque. Methods: Subjects were eligible if they had carotid stenosis between 50 and 99% and had MRA and CTA exams performed within 10 days of one another. We measured the soft (non-calcifie...
Source: Cerebrovascular Diseases - February 16, 2015 Category: Neurology Source Type: research

Rate of Peri-Hematomal Edema Expansion Predicts Outcome after Intracerebral Hemorrhage (S39.005)
CONCLUSIONS: PHE expansion rate predicts outcome in ICH and may represent a novel therapeutic target. Study Supported by: NIH-K12-NS049453 (LB); NINDS K23NS076597 (WTK); Leon Rosenberg, MD Medical Student Research Fund in Genetics, Yale School of Medicine; 2014 Student Scholarship in Cerebrovascular Disease and Stroke, AHA Stroke Council (SU)Disclosure: Dr. Urday has nothing to disclose. Dr. Beslow has nothing to disclose. Dr. Goldstein has nothing to disclose. Dr. Dai has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Vashkevich has received research support from the National Institutes of Health. Dr. Ayres h...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Urday, S., Beslow, L., Goldstein, D., Dai, F., Zhang, F., Vashkevich, A., Ayres, A., Battey, T., Simard, M., Rosand, J., Kimberly, W., Sheth, K. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research