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Specialty: Neurology
Condition: Anxiety
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Total 1068 results found since Jan 2013.
Mood and Cognitive Trajectories Over the First Year after Mild Ischemic Stroke
Cognitive and mood dysfunction are major contributors to post-stroke disability. The longer-term trajectories of mood and cognition post-stroke remain unclear, as do which cognitive domains decline, improve, or remain stable after stroke, and in which patients. We aimed to characterize the cognitive trajectories of mild ischemic stroke survivors over one year compared to stroke-free controls, and to investigate whether symptoms of anxiety and depression were associated with cognitive function.
Source: Journal of Stroke and Cerebrovascular Diseases - February 5, 2022 Category: Neurology Authors: Deena Ebaid, Laura J. Bird, Laura J.E. McCambridge, Emilio Werden, Jennifer Bradshaw, Toby Cumming, Eugene Tang, Amy Brodtmann Source Type: research
Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke
In this study, blockade of mPGES-1 by our several novel compounds abolished the lipopolysaccharide (LPS)-induced PGE2 and pro-inflammatory cytokines interleukin 1 β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α) in mouse primary brain microglia. Inhibition of mPGES-1 also decreased PGE2 produced by neuronal cells under oxygen –glucose deprivation (OGD) stress. Among the five enzymes for PGE2 biosynthesis, mPGES-1 was the most induced one in cerebral ischemic lesions. Systemic treatment with our lead compound MPO-0063 (5 or 10  mg/kg, i.p.) in mice after transient middle cerebral artery occlusion (MCAO) improved ...
Source: Neurotherapeutics - January 31, 2022 Category: Neurology Source Type: research
Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors
This study aimed to examine the effects of varenicline as α7 and α4β2 nicotine acetylcholine receptors (nAChRs) agonist, on cognitive impairment, inflammation, apoptosis, and synaptic dysfunction in mPFC ischemia. Mice were divided to three groups of control, sham, or photothrombotic mPFC ischemia model. The control and sham groups received 2 ml/kg of normal saline for a 14-day period. As well, the animals in the ischemia groups received normal saline (2 ml/kg) or varenicline at 0.1, 1, and 3 mg/kg doses for a 14-day period. Anxiety-like behaviors were then assessed by open field (OFT) and elevated plus-maze (EPM) tests...
Source: Brain Research Bulletin - January 23, 2022 Category: Neurology Authors: Fatemehsadat Seyedaghamiri Leila Hosseini Sareh Kazmi Javad Mahmoudi Dariush Shanehbandi Abbas Ebrahimi-Kalan Reza Rahbarghazi Saeed Sadigh-Eteghad Mehdi Farhoudi Source Type: research
Neurological toll of COVID-19
AbstractThe first case of coronavirus illness was discovered in Wuhan, China, in January 2020 and quickly spread worldwide within the next couple of months. The condition was initially only linked with respiratory disorders. After the evolution of various variants of the SARS-CoV-2, the critical impact of the virus spread to multiple organs and soon, neurological disorder manifestations started to appear in the infected patients. The review is focused on the manifestation of various neurological disorders linked with both the central nervous system and peripheral nervous system. Disorders such as cytokine release syndrome,...
Source: Neurological Sciences - January 16, 2022 Category: Neurology Source Type: research
Informing Patients with Acute Stroke About their Risk of Dementia: A Survey of UK Healthcare Professionals
People who have a stroke are at an increased risk of developing dementia.1,2 According to the 2021 James Lind Alliance –Stroke Association Priority Setting Partnership, cognitive issues after stroke are a key concern of people who have a stroke.3 Identifying which patients with acute stroke are at risk of dementia could help patients and their carers to plan for the future. However, informing a patient who has jus t had a stroke about their risk of dementia may cause anxiety.
Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2022 Category: Neurology Authors: Emily L. Ball, Gillian E. Mead, Eugene Y.H. Tang, Dorota Religa, Terence J. Quinn, Susan D. Shenkin Source Type: research
Feasibility of a remotely supervised home-based group eHealth Fitness and Mobility Exercise program for stroke: French-Canadian version preliminary study
CONCLUSION: FAME@home was feasible to deliver as a remotely supervised group exercise program to community-dwelling stroke survivors, with high levels of retention and adherence. FAME@home improved accessibility to exercise and facilitated engagement by having a class schedule and social interaction.PMID:34994303 | DOI:10.1080/10749357.2021.2012008
Source: Topics in Stroke Rehabilitation - January 7, 2022 Category: Neurology Authors: Marie-Andr ée Gagnon Charles S èbiyo Batcho Marie-Louise Bird Benoit Labb é Krista L Best Source Type: research
Unmet Needs for Rehabilitative Management in Common Health-Related Problems Negatively Impact the Quality of Life of Community-Dwelling Stroke Survivors
Conclusions: Unmet rehabilitative needs are prevalent among community-dwelling stroke survivors, and the proportion of unmet needs was high among non-physical domains such as anxiety/depression. The number of unmet needs is an independent negative predictor of HRQoL. Systematic approaches to identify unmet needs and provide appropriate rehabilitative management are required in long-term stroke survivors.
Source: Frontiers in Neurology - December 23, 2021 Category: Neurology Source Type: research
Identifying emotional contributors to participation post-stroke
CONCLUSIONS: Results suggested that emotional measures of apathy, depression, anxiety, and happiness, but not general emotion, were important contributors to participation post-stroke. These findings suggest that rehabilitation professionals should address individual emotional contributors to facilitate participation post-stroke.PMID:34877927 | DOI:10.1080/10749357.2021.2008597
Source: Topics in Stroke Rehabilitation - December 8, 2021 Category: Neurology Authors: Ms Yejin Lee Marjorie L Nicholas Lisa Tabor Connor Source Type: research
