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Primary healthcare needs and service utilisation of people with disability: a data linkage protocol
Introduction General practitioners (GPs) play a crucial role in the early management and treatment of the comorbidities and complications experienced by people with disability. However, GPs experience multiple constraints, including limited time and disability-related expertise. Knowledge gaps around the health needs of people with disability as well as the frequency and extent of their engagement with GPs mean evidence to inform practice is limited. Using a linked dataset, this project aims to enhance the knowledge of the GP workforce by describing the health needs of people with disability. Methods and analysis This pro...
Source: BMJ Open - April 19, 2023 Category: General Medicine Authors: Douglas, J., Winkler, D., McLeod, A., Oliver, S., Gardner, K., Supple, J., Pearce, C. Tags: Open access, Health services research Source Type: research

Regulation of the p53 ‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
Exp Ther Med. 2023 Jan 26;25(3):113. doi: 10.3892/etm.2023.11812. eCollection 2023 Mar.ABSTRACTStroke is one of the most threatening diseases worldwide, particularly in countries with larger populations; it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel ruptures) or ischemic stroke (blockage of an artery). Whilst the incidence of stroke is higher in the elderly population (≥65), it is also increasing in the younger population. Ischemic stroke accounts for ~85% of a...
Source: Experimental and Therapeutic Medicine - February 16, 2023 Category: General Medicine Authors: Shuangli Xu Xuewei Li Yanqiang Wang Source Type: research

Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report
ConclusionOwing to the link between coronavirus disease 2019 and hematologic cancers with hypercoagulopathy and the tendency of patients with leukemia to have coronavirus disease 2019 complications, children with leukemia as well as suspected coronavirus disease 2019 must be hospitalized to prevent blood clot formation.
Source: Journal of Medical Case Reports - December 6, 2022 Category: General Medicine Source Type: research

Burden of neurological diseases in Asia from 1990 to 2019: a systematic analysis using the Global Burden of Disease Study data
Conclusions This study demonstrated the burden of neurological diseases in Asia. To reduce the burden of neurological diseases, strategies suitable for each country’s real healthcare needs and challenges are needed; this study can serve as the cornerstone of these strategies.
Source: BMJ Open - September 7, 2022 Category: General Medicine Authors: Kang, S., Eum, S., Chang, Y., Koyanagi, A., Jacob, L., Smith, L., Shin, J. I., Song, T.-J. Tags: Open access, Epidemiology Source Type: research

Public perceptions of brain health: an international, online cross-sectional survey
Conclusions Differences in perceptions of brain health were noted among specific segments of the population. Policies providing information about brain-friendly health behaviours and targeting people less likely to have relevant experience may be needed.
Source: BMJ Open - April 18, 2022 Category: General Medicine Authors: Budin-Ljosne, I., Mowinckel, A. M., Friedman, B. B., Ebmeier, K. P., Drevon, C. A., Carver, R. B., Zsoldos, E., Fredheim, N. A. G., Sorensen, O., Baare, W. F. C., Madsen, K. S., Fjell, A. M., Kievit, R. A., Ghisletta, P., Bartres-Faz, D., Nawijn, L., Sole Tags: Open access, Public health Source Type: research

Clinical Differences Between Stroke and Stroke Mimics in Code Stroke Patients
CONCLUSION: Some clinical and neurological characteristics have been identified to help differentiate stroke mimics from true stroke. In particular, the likelihood of stroke tended to increase as the number of accompanying focal neurological deficits increased.PMID:35191231 | DOI:10.3346/jkms.2022.37.e54
Source: J Korean Med Sci - February 22, 2022 Category: General Medicine Authors: Taekwon Kim Han-Yeong Jeong Gil Joon Suh Source Type: research

The relationship between malignant tumors and ischemic stroke: I. Thrombosis development and shared risk factors
Orv Hetil. 2022 Jan 2;163(1):3-11. doi: 10.1556/650.2021.32328. Print 2022 Jan 2.ABSTRACTÖsszefoglaló. A malignus daganat és a stroke egy-egy betegnél gyakran kombinálódik, sokszor egyidejűleg diagnosztizálják, vagy rövid idő telik el a két kórkép felismerése között. Az együttes megjelenés hátterében elsősorban a hasonló tradicionális rizikófaktorok állhatnak: az idősebb életkor, a magas vérnyomás, a hyperlipidaemia, a cukorbetegség, az elhízás és a dohányzás. Az átfedő kockázati tényezőkön túl a daganat által okozott hiperkoaguláció artériás és vénás thrombosis kialakulá...
Source: Orvosi Hetilap - January 2, 2022 Category: General Medicine Authors: N óra Hajnóczky D ániel Bereczki Source Type: research

Transfusion thresholds for guiding red blood cell transfusion
CONCLUSIONS: Transfusion at a restrictive haemoglobin concentration decreased the proportion of people exposed to RBC transfusion by 41% across a broad range of clinical contexts. Across all trials, no evidence suggests that a restrictive transfusion strategy impacted 30-day mortality, mortality at other time points, or morbidity (i.e. cardiac events, myocardial infarction, stroke, pneumonia, thromboembolism, infection) compared with a liberal transfusion strategy. Despite including 17 more randomised trials (and 8846 participants), data remain insufficient to inform the safety of transfusion policies in important and sele...
Source: Cochrane Database of Systematic Reviews - December 21, 2021 Category: General Medicine Authors: Jeffrey L Carson Simon J Stanworth Jane A Dennis Marialena Trivella Nareg Roubinian Dean A Fergusson Darrell Triulzi Carolyn Dor ée Paul C H ébert Source Type: research

Interactions between remote ischemic conditioning and post-stroke sleep regulation
AbstractSleep disturbances are common in patients with stroke, and sleep quality has a critical role in the onset and outcome of stroke. Poor sleep exacerbates neurological injury, impedes nerve regeneration, and elicits serious complications. Thus, exploring a therapy suitable for patients with stroke and sleep disturbances is imperative. As a multi-targeted nonpharmacological intervention, remote ischemic conditioning can reduce the ischemic size of the brain, improve the functional outcome of stroke, and increase sleep duration. Preclinical/clinical evidence showed that this method can inhibit the inflammatory response,...
Source: Frontiers of Medicine - November 23, 2021 Category: General Medicine Source Type: research

Emerging roles of growth differentiation factor-15 in brain disorders (Review)
Exp Ther Med. 2021 Nov;22(5):1270. doi: 10.3892/etm.2021.10705. Epub 2021 Sep 7.ABSTRACTBrain disorders, such as Alzheimer's and Parkinson's disease and cerebral stroke, are an important contributor to mortality and disability worldwide, where their pathogenesis is currently a topic of intense research. The mechanisms underlying the development of brain disorders are complex and vary widely, including aberrant protein aggregation, ischemic cell necrosis and neuronal dysfunction. Previous studies have found that the expression and function of growth differentiation factor-15 (GDF15) is closely associated with the incidence ...
Source: Experimental and Therapeutic Medicine - October 1, 2021 Category: General Medicine Authors: Wei-Wei Jiang Zi-Zhen Zhang Ping-Ping He Li-Ping Jiang Jin-Zhi Chen Xing-Ting Zhang Mi Hu Yang-Kai Zhang Xin-Ping Ouyang Source Type: research

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