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Characterization in nonhuman primates of (R)-18FOF-Me-NB1 and (S)-18FOF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor
ConclusionsIn rhesus monkeys, (R)-[18F]OF-Me-NB1 exhibited fast kinetics and heterogeneous uptake across brain regions, while the (S)-enantiomer displayed a narrower dynamic range of uptake across regions. A Blocking study with a GluN2B antagonist indicated binding specificity. The value ofBPND was  >  0.5 in most brain regions, suggesting goodin vivo specific binding signals. Taken together, results from the current study demonstrated the potential of (R)-[18F]OF-Me-NB1 as a useful radiotracer for imaging the GluN2B receptors.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 2, 2022 Category: Nuclear Medicine Source Type: research

Crossed cerebellar diaschisis on 18F-FDG PET across neurodegenerative diseases: frequency and association with 11C-PIB and 18F-FTP
Conclusions: CCD is present in a significant proportion of patients with neurodegenerative diseases, and is more prevalent in specific phenotypes, especially in typically asymmetric presentations such as CBS, svPPA and lvPPA. The association between CCD on 18F-FDG and cortical 18F-FTP suggests a Tau-related disruption of cortico-ponto-cerebellar pathways in amyloid-positive patients, while amyloid does not seem to play a significant role. Further studies are required to elucidate prognostic value or clinical correlate of CCD. Table 1. Patient characteristics and prevalence of crossed cerebellar diaschisis (CCD) by diagnosi...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Provost, K., Strom, A., Iaccarino, L., Edwards, L., Mellinger, T., Pham, J., Baker, S., Miller, B., Jagust, W., La Joie, R., Rabinovici, G. Tags: Neurodegenerative Diseases Source Type: research

The Use of Random Forests to Identify Brain Regions on Amyloid and FDG PET Associated With MoCA Score
Conclusions Random forests help pinpoint clinically relevant ROIs associated with MoCA score; amyloid increased and 18F-FDG decreased with decreasing MoCA score, most significantly in the posterior cingulate gyrus.
Source: Clinical Nuclear Medicine - May 8, 2020 Category: Nuclear Medicine Tags: Original Article Source Type: research

The Use of Random Forests to Classify Amyloid Brain PET
Conclusions Random forests can classify brain PET as positive or negative for amyloid deposition and suggest key clinically relevant, regional features for classification.
Source: Clinical Nuclear Medicine - September 11, 2019 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Alzheimers Disease: A Review of Recent Developments and the Role of Imaging
1114Purpose: Alzheimer’s disease (AD), the most common form of dementia, is a devastating illness that will affect an estimated 5.7 million Americans and almost 50 million people worldwide in 2018, with numbers expected to nearly triple by 2050. While mortality related to heart disease and stroke has continued to decline, the rate of AD-related death in the United States more than doubled in the period from 2000-2015. Now the 6th leading cause of death, it is the least preventable and treatable of the major causes, and places a tremendous financial, physical, and emotional burden on the estimated 16 million unpaid ca...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Ismail, H., Wang, L. Tags: Educational Exhibit Posters Source Type: research

Bioinks and in vitro neurovascular unit production - New prospects in Alzheimer's disease research.
Authors: Lougiaki P, Tsolaki M, Pantazaki A Abstract Neurovascular dysfunction is a central process in the pathogenesis of the stroke and most neurodegenerative diseases, including Alzheimer's disease. The multi-cell neurovascular unit (NVU) combines the components of the neural, vascular and extracellular matrix (ECM) into an important interface whose proper function is critical to maintaining brain health. Tissue engineering now offers new tools and information to promote understanding of NVU's operation. A promising area for the development of NVU models is their bio-production through 3D bio-printing to produce...
Source: Hellenic Journal of Nuclear Medicine - March 17, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Imaging of Blood-Brain Barrier Disruption by Tc-99m-Tilmanocept Molecular Imaging of a Rodent Model of Traumatic Brain Injury
Conclusions: These results are consistent with the hypothesis that microglial cells bearing CD206 trap fluorescent-labeled Tc-99m-tilmanocept in regions of BBB disruption. This provides the motivation for a clinical trial of intra-venously administered Tc-99m-tilmanocept with the goal of developing a SPECT/CT protocol for the detection of neuro-inflammation.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Vera, D., Barback, C., Wang, S., Head, B., Hoh, C. Tags: Basic Science II Source Type: research

Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases
AbstractNeuroinflammation is heavily associated with various neurological diseases including Alzheimer ’s disease, Parkinson’s disease, multiple sclerosis, and stroke. It is strongly characterized by the activation of microglia which can be visualized using position emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) has been the preferred target for imaging the inflamma tory progression of the microglial component. TSPO is expressed in the outer mitochondrial membrane and present in very low concentrations in the healthy human brain, but is markedly upregulated in response to brain injury and...
Source: Nuclear Medicine and Molecular Imaging - March 15, 2017 Category: Nuclear Medicine Source Type: research

Improvement of Cerebral Glucose Metabolism in Symptomatic Patients With Carotid Artery Stenosis After Stenting
Conclusions: Successful CAS may improve long-term cerebral glucose metabolism and neurocognitive function in patients with chronic severe carotid stenosis or occlusion.
Source: Clinical Nuclear Medicine - August 11, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research