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Total 109 results found since Jan 2013.

Where language meets meaningful action: a combined behavior and lesion analysis of aphasia and apraxia
Abstract It is debated how language and praxis are co-represented in the left hemisphere (LH). As voxel-based lesion-symptom mapping in LH stroke patients with aphasia and/or apraxia may contribute to this debate, we here investigated the relationship between language and praxis deficits at the behavioral and lesion levels in 50 sub-acute stroke patients. We hypothesized that language and (meaningful) action are linked via semantic processing in Broca’s region. Behaviorally, half of the patients suffered from co-morbid aphasia and apraxia. While 24 % (n = 12) of all patients exhibited aphasia without apraxia,...
Source: Anatomy and Embryology - October 29, 2014 Category: Anatomy Source Type: research

Distribution of the hematopoietic growth factor G-CSF and its receptor in the adult human brain with specific reference to Alzheimer's disease.
Abstract The granulocyte colony-stimulating factor (G-CSF), being a member of the hematopoietic growth factor family, is also critically involved in controlling proliferation and differentiation of neural stem cells. Treatment with G-CSF has been shown to result in substantial neuroprotective and neuroregenerative effects in various experimental models of acute and chronic diseases of the central nervous system. Although G-CSF has been tested in a clinical study for treatment of acute ischemic stroke, there is only fragmentary data on the distribution of this cytokine and its receptor in the human brain. Therefore...
Source: Journal of Anatomy - January 5, 2014 Category: Anatomy Authors: Ridwan S, Bauer H, Frauenknecht K, Hefti K, von Pein H, Sommer CJ Tags: J Anat Source Type: research

Evaluation of Hippocampal Injury and Cognitive Function Induced by Embolization in the Rat Brain.
Abstract Embolism is responsible for at least 20% of all stroke and half of cerebral infarctions. A number of animal models have been developed to mimic thromboembolic stroke. However, little aimed directly at hippocampal damage and cognitive function. In the present study, three sizes of emboli (150-178 μm, 74-124 μm, and 48-74 μm) were employed to induce thromboembolic stroke model in rats. Results showed that the diameter of the particle was critical for animal behavioral and histopathological consequences. Hematoxylin-eosin (HE) staining revealed that CA1 and CA2-3, which are two of the main hippocampal sub...
Source: Anatomical Record - June 1, 2013 Category: Anatomy Authors: Zhang HA, Gao M, Chen B, Shi L, Wang Q, Yu X, Xuan Z, Gao L, Du G Tags: Anat Rec (Hoboken) Source Type: research

Evaluation of Hippocampal Injury and Cognitive Function Induced by Embolization in the Rat Brain
ABSTRACT Embolism is responsible for at least 20% of all stroke and half of cerebral infarctions. A number of animal models have been developed to mimic thromboembolic stroke. However, little aimed directly at hippocampal damage and cognitive function. In the present study, three sizes of emboli (150–178 μm, 74–124 μm, and 48–74 μm) were employed to induce thromboembolic stroke model in rats. Results showed that the diameter of the particle was critical for animal behavioral and histopathological consequences. Hematoxylin–eosin (HE) staining revealed that CA1 and CA2–3, which are two of the main hippocampal su...
Source: The Anatomical Record Part B: The New Anatomist - June 1, 2013 Category: Anatomy Authors: Heng‐Ai Zhang, Mei Gao, Bainian Chen, Lili Shi, Qiaoyun Wang, Xiaoyan Yu, Zhaohong Xuan, Li Gao, Guanhua Du Tags: Full Length Article Source Type: research