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Total 109 results found since Jan 2013.
Longitudinal prediction of motor dysfunction after stroke: a disconnectome study
AbstractMotricity is the most commonly affected ability after a stroke. While many clinical studies attempt to predict motor symptoms at different chronic time points after a stroke, longitudinal acute-to-chronic studies remain scarce. Taking advantage of recent advances in mapping brain disconnections, we predict motor outcomes in 62 patients assessed longitudinally two weeks, three months, and one year after their stroke. Results indicate that brain disconnection patterns accurately predict motor impairments. However, disconnection patterns leading to impairment differ between the three-time points and between left and r...
Source: Anatomy and Embryology - November 5, 2022 Category: Anatomy Source Type: research
The impact of aging on human brain network target controllability
AbstractUnderstanding how few distributed areas can steer large-scale brain activity is a fundamental question that has practical implications, which range from inducing specific patterns of behavior to counteracting disease. Recent endeavors based on network controllability provided fresh insights into the potential ability of single regions to influence whole brain dynamics through the underlying structural connectome. However, controlling the entire brain activity is often unfeasible and might not always be necessary. The question whether single areas can control specific target subsystems remains crucial, albeit still ...
Source: Anatomy and Embryology - October 23, 2022 Category: Anatomy Source Type: research
White matter microstructure and verbal fluency
We examined white matter correlates of semantic (Category Fluency Animals) and phonemic or lexical fluency (COWAT FAS) after stroke, accounting for stroke severity measured with the Nation al Institutes of health Stroke Scale (NIHSS), age, sex, and level of education. White matter fibre density and cross-section measures were automatically extracted from 72 tracts, using MRtrix and TractSeg software in 72 ischaemic stroke survivors assessed 3 months after their event. We conducted re gression analyses separately for phonemic and semantic fluency for each tract. Worse semantic fluency was associated with lower fibre densit...
Source: Anatomy and Embryology - October 17, 2022 Category: Anatomy Source Type: research
Stroke disconnectome decodes reading networks
In this study, we used such a novel method, called the disconnectome, to decode the reading circuitry in the brain. We used the resulting disconnection patterns to predict a typical lesion that would lead to reading deficits after brain damage. Our results suggest that white matter connections critical for reading include fronto-parietal U-shaped fibres and the vertical occipital fascicul us (VOF). The lesion most predictive of a reading deficit would impinge on the left temporal, occipital, and inferior parietal gyri. This novel framework can systematically be applied to bridge the gap between the neuropathology of langua...
Source: Anatomy and Embryology - October 3, 2022 Category: Anatomy Source Type: research
Morphometrical features of left atrial appendage in the AF patients subjected to left atrial appendage closure
CONCLUSIONS: Important morphometrical differences in LAA orifice have been found, which was significantly larger and more oval in patients with atrial fibrillation compared to healthy controls. Although no difference in LAA body type and size was observed; the LAA ejection fraction was significantly lower in atrial fibrillation rhythm patients.PMID:36165901 | DOI:10.5603/FM.a2022.0080
Source: Folia Morphologica - September 27, 2022 Category: Anatomy Authors: K M Slodowska J Batko J P Holda D Dudkiewicz M Koziej R Litwinowicz K Bartus M K Holda Source Type: research
Right-side spatial neglect and white matter disconnection after left-hemisphere strokes
AbstractSpatial neglect usually concerns left-sided events after right-hemisphere damage. Its anatomical correlates are debated, with evidence suggesting an important role for fronto-parietal white matter disconnections in the right hemisphere. Here, we describe the less frequent occurrence of neglect for right-sided events, observed in three right-handed patients after a focal stroke in the left hemisphere. Patients were tested 1 month and 3 months after stroke. They performed a standardized paper-and-pencil neglect battery and underwent brain MRI with both structural and diffusion tensor (DT) sequences, in order to asses...
Source: Anatomy and Embryology - August 4, 2022 Category: Anatomy Source Type: research
Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation
Folia Morphol (Warsz). 2022 Aug 2. doi: 10.5603/FM.a2022.0068. Online ahead of print.ABSTRACTLithium chloride (LiCl) has a significant neuroprotective effect in cerebral ischemia. However, to date, there is a paucity of evidence on the role of LiCl in neural restoration after brain ischemia and the signaling pathways involved remain unclear. Therefore, to address this gap, the middle cerebral artery occlusion (MCAO) rat model was used to simulate human ischemia stroke. Male SD rats were given MCAO for 90 min followed by reperfusion, and Dickkopf-1(DKK1, 5.0 μg/kg) was administered half an hour before MCAO. Rats were then ...
Source: Folia Morphologica - August 2, 2022 Category: Anatomy Authors: Z Junde L Tingting Z Lu C Shan Y Dan Source Type: research
