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Real world evidence of improved attention and cognition during physical therapy paired with neuromodulation: a brain vital signs study
DiscussionThe current study highlighted real-world neuromodulation improvements in neurophysiological correlates of attention. Overall, the real-world findings support the concept of neuromodulation-related improvements extending beyond physical therapy to include potential attention benefits for cognitive rehabilitation.
Source: Frontiers in Human Neuroscience - June 9, 2023 Category: Neuroscience Source Type: research

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Regulatory T cells promote functional recovery after spinal cord injury by alleviating microglia inflammation via STAT3 inhibition
CONCLUSION: Our results suggest that Tregs promote functional recovery after SCI by alleviating microglia inflammatory reaction via STAT3.PMID:36914969 | DOI:10.1111/cns.14161
Source: CNS Neuroscience and Therapeutics - March 14, 2023 Category: Neuroscience Authors: Rui Liu Ying Li Ziyue Wang Peng Chen Yi Xie Wensheng Qu Minghuan Wang Zhiyuan Yu Xiang Luo Source Type: research

Molecular Mechanism of the Protective Effects of M2 Microglia on Neurons: A Review Focused on Exosomes and Secretory Proteins
Neurochem Res. 2022 Oct 12. doi: 10.1007/s11064-022-03760-4. Online ahead of print.ABSTRACTMicroglia, as innate immune cells in the brain, closely monitor changes in the internal environment and participate in the maintenance of homeostasis in the central nervous system (CNS). Microglia can be polarized to the M1 or M2 phenotype in response to various stimuli in vivo or in vitro, affecting the functions of peripheral neurons. M2 microglia have attracted increasing attention in recent years owing to their beneficial effects on various diseases and injuries of the CNS, such as traumatic brain injury, stroke, Alzheimer's dise...
Source: Neurochemical Research - October 12, 2022 Category: Neuroscience Authors: Miao Chai Gang Su Juan Gao Wei Chen Qionghui Wu Ying Dong He Wang Deyi Chen Yonghong Li Xin Gao Ruixin Li Tianfei Ma Zhenchang Zhang Source Type: research

The Effect of Cerebellar rTMS on Modulating Motor Dysfunction in Neurological Disorders: a Systematic Review
Cerebellum. 2022 Aug 26. doi: 10.1007/s12311-022-01465-6. Online ahead of print.ABSTRACTThe effectiveness of cerebellar repetitive transcranial magnetic stimulation (rTMS) on motor dysfunction in patients with neurological disorders has received increasing attention because of its potential for neuromodulation. However, studies on the neuromodulatory effects, parameters, and safety of rTMS implementation in the cerebellum to alleviate motor dysfunction are limited. This systematic review aimed to evaluate the effectiveness and safety of cerebellar rTMS treatment for motor dysfunction caused by neurological disorders and to...
Source: Cerebellum - August 26, 2022 Category: Neuroscience Authors: Yifei Xia Mingqi Wang Yulian Zhu Source Type: research

Sphingosine ‐1‐phosphate receptor modulators in stroke treatment
AbstractSphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G protein-coupled receptors. S1P receptor modulators are a new group of immunosuppressive agents currently used in the immunotherapy of multiple sclerosis. Inflammation following stroke may exacerbate injury. Given that S1P signaling is linked to multiple immune processes, therapies targeting the S1P axis may be suitable for treating stroke. In this review, we outline S1P metabolism and S1P receptors, discuss the mechanisms of action of S1P receptor modulators i...
Source: Journal of Neurochemistry - August 9, 2022 Category: Neuroscience Authors: Wanzhou Zhang, Yudi Li, Fangming Li, Li Ling Tags: REVIEW Source Type: research

Stroke risk in multiple sclerosis: a critical appraisal of the literature
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Source: International Journal of Neuroscience - April 3, 2022 Category: Neuroscience Authors: Triantafyllos Doskas Efthimios Dardiotis George D. Vavougios Konstantinos T. Ntoskas Pinelopi Sionidou Konstantinos Vadikolias Source Type: research

Non-coding RNAs in the regulation of blood –brain barrier functions in central nervous system disorders
AbstractThe blood –brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain. BBB damage is a common feature of different central nervous systems (CNS) disorders and plays a vital role in the pathogenesis of t he diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), and circular RNAs (circRNAs), are important regulatory RNA molecules that are involved in almost all cellular processes in normal development and various diseases, including CNS diseases. Cumulative evi dences hav...
Source: Fluids and Barriers of the CNS - March 26, 2022 Category: Neuroscience Source Type: research

The neurovascular unit in leukodystrophies: towards solving the puzzle
AbstractThe neurovascular unit (NVU) is a highly organized multicellular system localized in the brain, formed by neuronal, glial (astrocytes, oligodendrocytes, and microglia) and vascular (endothelial cells and pericytes) cells. The blood –brain barrier, a complex and dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma, is a component of the NVU. In a variety of neurological disorders, including Alzheimer’s disease, multiple sclerosis, and stroke, dysfunctions of the N VU occurs. There is, however, a lack of knowledge regarding the NVU function in leukodyst...
Source: Fluids and Barriers of the CNS - February 28, 2022 Category: Neuroscience Source Type: research

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