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Protamine Reduces Serious Bleeding Complications Associated with Carotid Endarterectomy in Asymptomatic Patients without Increasing the Risk of Stroke, Myocardial Infarction, or Death in a Large National Analysis.
CONCLUSION: Protamine reduces serious bleeding complications at the time of CEA without increasing the risk of MI, stroke, or death, in this large North American analysis. Based on this and previous regional work regarding protamine use in CEA, it is believed that there is now sufficient evidence to support its routine use, and it should be considered as a benchmark for quality during CEA. PMID: 33127243 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - October 27, 2020 Category: Surgery Authors: Stone DH, Giles KA, Kubilis P, Suckow BD, Goodney PP, Huber TS, Powell RJ, Cronenwett JL, Scali ST Tags: Eur J Vasc Endovasc Surg Source Type: research

Safety of Simultaneous Coronary Artery Bypass Grafting and Carotid Endarterectomy Versus Isolated Coronary Artery Bypass Grafting Clinical Sciences
Conclusions—Although our results cannot rule out a treatment-group effect because of lack of power, a superiority of the synchronous combined carotid endarterectomy+CABG approach seems unlikely. Five-year follow-up of patients is still ongoing.Clinical Trial Registration—URL: https://www.controlled-trials.com. Unique identifier: ISRCTN13486906.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Christian Weimar, Konstantinos Bilbilis, Jan Rekowski, Torulv Holst, Friedhelm Beyersdorf, Martin Breuer, Manfred Dahm, Anno Diegeler, Arne Kowalski, Sven Martens, Friedrich W. Mohr, Jiri Ondrašek, Beate Reiter, Peter Roth, Ralf Seipelt, Markus Sig Tags: Cardiovascular Surgery Original Contributions Source Type: research

Treatment of a hot carotid: More fuel is needed to clarify the best treatments
The majority of patients presenting with a stroke or TIA receive imaging for carotid stenosis. Treatment of symptomatic carotid stenosis is familiar to most neurologists since high-profile clinical trials have been conducted in the past. The most well-known in North America is the North American Symptomatic Carotid Endarterectomy Trial (NASCET).1 NASCET and additional analysis by Rothwell et al.2 led to the recommendation that if the patient is an otherwise suitable candidate for carotid endarterectomy (CEA), then performing the operation within 2 weeks of the last symptomatic event is desirable.
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: Chaturvedi, S. Tags: CT, Stroke prevention, Ultrasound, All Cerebrovascular disease/Stroke, Practice Current Editorial Source Type: research

Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression
CONCLUSIONS: Circulating IL-6 predicts carotid plaque severity, vulnerability, and progression. The 2.0 pg/mL cutoff could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.PMID:35713008 | DOI:10.1161/CIRCRESAHA.122.320877
Source: Circulation Research - June 17, 2022 Category: Cardiology Authors: Joseph Kamtchum-Tatuene Luca Saba Mirjam R Heldner Michiel H F Poorthuis Gert J de Borst Tatjana Rundek Stavros K Kakkos Seemant Chaturvedi Raffi Topakian Joseph F Polak Glen C Jickling Carotid Atherosclerosis and Stroke Collaboration (CASCO) Source Type: research

The Impact of Full Collapse on the Risk of Ischaemic Stroke in Patients with Carotid Near Occlusion
Carotid near occlusion (CNO) is a severe carotid stenosis associated with a reduction in the calibre of the extracranial internal carotid artery distal to the stenosis.1 The risk of ipsilateral stroke in patients with CNO is a controversial issue. While a post hoc analysis of the North American Symptomatic Carotid Endarterectomy Trial (NASCET) and the European Carotid Surgery Trial (ECST) reported a lower risk of ipsilateral stroke for medically treated patients with CNO compared with patients with severe (70 –99%) carotid stenosis2, more recent studies have shown that the CNO recurrence rate may be higher.
Source: European Journal of Vascular and Endovascular Surgery - April 20, 2023 Category: Surgery Authors: Andr és García-Pastor, Ana Iglesias-Mohedano, Antonio Gil-Núñez Tags: Editorial Source Type: research

PC052. The Effects of Stroke Unit Centralization for Patients With a Symptomatic Carotid Stenosis in the Carotid Endarterectomy Pathway
Carotid endarterectomy (CEA) should be performed on symptomatic, surgically suitable patients who present a stenosis greater than 50% North American Symptomatic Carotid Endarterectomy Trial stenosis of the internal carotid artery within 14 days of their symptoms. Aim of this study was to evaluate the effects of Stroke Uni centralization for patients with symptomatic carotid stenosis undergoing CEA.
Source: Journal of Vascular Surgery - May 22, 2018 Category: Surgery Authors: Emiliano Chisci, Lorenzo Nenci, Giulia Zaccagnini, Alberto Fortini, Gabriele Nenci, Luciana Tramacere, Massimo Cincotta, Stefano Michelagnoli Source Type: research

Plaque Contact Surface Area and Flow Lumen Volume Predict Stroke Risk in Extracranial Carotid Artery Stenosis
The ability to predict culprit lesions in the extracranial carotid circulation remains limited. The standard indication for intervention in asymptomatic disease is currently percent stenosis in the internal carotid artery as measured by the North American Symptomatic Carotid Endarterectomy Trial (NASCET) method. Computed tomography angiography (CTA) offers the opportunity to analyze carotid artery plaques from a morphologic perspective. Here, we aim to improve stroke risk stratification of patients with carotid artery stenosis using plaque 3D modeling and analysis.
Source: Journal of Vascular Surgery - August 24, 2021 Category: Surgery Authors: Ryan Gedney, Veena Mehta, Matthew Bridges, Adam Brown, Ravi Veeraswamy Tags: S2: Plenary Session 2 Source Type: research

Unplanned readmission after carotid stenting versus endarterectomy: analysis of the United States Nationwide Readmissions Database
Conclusions Readmission is not uncommon after carotid revascularization, occurs more often after CAS, and is predicted by baseline factors and by preventable adverse events at initial admission.
Source: Journal of NeuroInterventional Surgery - February 14, 2023 Category: Neurosurgery Authors: Nazari, P., Golnari, P., Ansari, S. A., Cantrell, D. R., Potts, M. B., Jahromi, B. S. Tags: Open access, Ischemic stroke Source Type: research

Using a CT Angiography Artificial Intelligence Carotid Plaque Morphology Model to Predict Stroke
The gold standard for determining carotid artery stenosis is to calculate stenosis using the North American Symptomatic Carotid Endarterectomy Trial criteria and ultimately plan for medical vs surgical management based on percent stenosis and symptomatic status. Few studies have assessed plaque morphology as an additive tool for stroke prediction. Our study uses an artificial intelligence software in conjunction with a patient's computed tomography (CT) scan of the neck to create a three-dimensional (3D) model of the carotid artery and assess plaque morphology including calcification, intraplaque hemorrhage, matrix, and pe...
Source: Journal of Vascular Surgery - May 23, 2023 Category: Surgery Authors: Rohini J. Patel, Daniel Willie-Permor, Sina Zarrintan, Austin Fan, Mahmoud Malas Tags: Poster Competition Source Type: research

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