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Total 27 results found since Jan 2013.
MRI for all: Cheap portable scanners aim to revolutionize medical imaging
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The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing.
The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research
Clot-targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis
CONCLUSIONS: This study demonstrates that clot-targeted MH can enhance the thrombolysis of contracted human blood clots and can be safely applied to enhance the timeframe in which thrombolysis is effective.PMID:35950914 | DOI:10.1111/jth.15846
Source: Thrombosis and Haemostasis - August 11, 2022 Category: Hematology Authors: David Cabrera Maneea Eizadi Sharifabad Jacob A Ranjbar Neil D Telling Alan G S Harper Source Type: research
E-205 In vitro evaluation of full-length, mr-safe interventional passive catheter markers at 3T
ConclusionAlthough worst-case artifacts were observed at 90°, they remained acceptable for use in guide catheters. Additionally, 20-mm marker separation could provide distinct artifacts down the length of a catheter during MRI-guided interventions, despite anatomic tortuosity. The phantom used in this study was shallow, which limited the ability to distinguish between real artifacts and those arising from the solution-air interface. Hence, accuracy of the degree of increased artifact may warrant further investigation. This study simulated worst-case orientations in vitro; more data should be collected in vivo using rea...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kilbride, B., Jordan, C., Ahn, S., Mueller, K., Chu, A., Barry, D., Moore, T., Martin, A., Wilson, M., Hetts, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
Bibliometric Analysis of Ferroptosis in Stroke From 2013 to 2021
Conclusion: Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic “ferroptosis in stroke”, to produce more exciting results and provide new insights into the bottleneck of stroke treatment.
Source: Frontiers in Pharmacology - February 21, 2022 Category: Drugs & Pharmacology Source Type: research
Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging.
Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging.
Mol Med Rep. 2021 Apr;23(4):
Authors: Zhuang L, Kong Y, Yang S, Lu F, Gong Z, Zhan S, Liu M
Abstract
The inflammatory response and apoptosis are key factors in cerebral ischemia‑reperfusion injury. The severity of the inflammatory reaction and apoptosis has an important impact on the prognosis of stroke. The ultrasmall superparamagnetic iron oxide particle has provided an effective magnetic resonance molecular imaging method for dynamic ...
Source: Molecular Medicine - February 20, 2021 Category: Molecular Biology Authors: Zhuang L, Kong Y, Yang S, Lu F, Gong Z, Zhan S, Liu M Tags: Mol Med Rep Source Type: research
Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging
Mol Med Rep. 2021 Apr;23(4):1-13. doi: 10.3892/mmr.2021.11921. Epub 2021 Feb 19.ABSTRACTThe inflammatory response and apoptosis are key factors in cerebral ischemia‑reperfusion injury. The severity of the inflammatory reaction and apoptosis has an important impact on the prognosis of stroke. The ultrasmall superparamagnetic iron oxide particle has provided an effective magnetic resonance molecular imaging method for dynamic observation of the cell infiltration process in vivo. The aims of the present study were to investigate the inflammatory response of cerebral ischemia‑reperfusion injury in mice using ferumoxytol‑...
Source: Molecular Medicine Reports - February 19, 2021 Category: Molecular Biology Authors: Lihua Zhuang Yingnan Kong Shuohui Yang Fang Lu Zhigang Gong Songhua Zhan Mengxiao Liu Source Type: research
The Evaluation of 68 Ga-Citrate PET/CT Imaging for Dihydroartemisinin in the Treatment of Rheumatoid Arthritis
ConclusionsThis study showed that the anti-inflammatory effect of the iron-responsive product DHA in arthritis can be monitored by an iron-like radioactive tracer (68Ga-citrate).
Source: Molecular Imaging and Biology - August 24, 2020 Category: Molecular Biology Source Type: research
Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia
Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress, reflected by elevated oxygen extraction fraction (OEF), which likely drives stroke risk reduction. The region of highest OEF falls within the border zone, where cerebral blood flow (CBF) nadirs; OEF in this region was reduced after CTT. The neuroprotective efficacy of hydroxyurea (HU) remains unclear. To test our hypothesis that patients receiving HU therapy have lower cerebral metabolic stress compared with patients not receiving disease-modifying t...
Source: Blood - May 29, 2019 Category: Hematology Authors: Fields, M. E., Guilliams, K. P., Ragan, D., Binkley, M. M., Mirro, A., Fellah, S., Hulbert, M. L., Blinder, M., Eldeniz, C., Vo, K., Shimony, J. S., Chen, Y., McKinstry, R. C., An, H., Lee, J.-M., Ford, A. L. Tags: Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis Source Type: research
