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Preserved Ratio Impaired Spirometry in Relation to Cardiovascular Outcomes: A Large Prospective Cohort Study
Chest. 2022 Nov 10:S0012-3692(22)04064-8. doi: 10.1016/j.chest.2022.11.003. Online ahead of print.ABSTRACTBACKGROUND: Preserved ratio impaired spirometry (PRISm) is a heterogeneous condition characterized by a normal forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio with underlying impairment of pulmonary function. Data relating to the association of baseline and trajectories of PRISm with diverse cardiovascular outcomes is sparse.RESEARCH QUESTION: How do baseline and trajectories of PRISm impact subsequent cardiovascular events?STUDY DESIGN AND METHODS: In the UK Biobank cohort study, we included c...
Source: Chest - November 13, 2022 Category: Respiratory Medicine Authors: Jiazhen Zheng Rui Zhou Yingchai Zhang Kelei Su Haowen Chen Furong Li Daniel Nyarko Hukportie Fangbing Niu Kaihang Yiu Xianbo Wu Source Type: research

Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study
Publication date: May 2019Source: The Lancet Global Health, Volume 7, Issue 5Author(s): MyLinh Duong, Shofiqul Islam, Sumathy Rangarajan, Darryl Leong, Om Kurmi, Koon Teo, Kieran Killian, Gilles Dagenais, Scott Lear, Andreas Wielgosz, Sanjeev Nair, Viswanathan Mohan, Prem Mony, Rajeev Gupta, Rajesh Kumar, Omar Rahman, Khalid Yusoff, Johannes Lodewykus du Plessis, Ehimario U Igumbor, Jephat ChifambaSummaryBackgroundThe associations between the extent of forced expiratory volume in 1 s (FEV1) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations mi...
Source: The Lancet Global Health - April 17, 2019 Category: International Medicine & Public Health Source Type: research

Patient characteristics of new initiators of glycopyrronium bromide (GLY) - A multinational, multi-database real-world drug-utilization study
Conclusion: In real life, majority of first-time GLY use was in line with product label regarding dosing and COPD severity. More than 1/4 of patients used long-acting bronchodilators before GLY start. Cardiovascular comorbidity was considerable.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Verhamme, K. M. C., De Ridder, M., Pedersen, L., Prieto-Alhambra, D., Lapi, F., Rijnbeek, P., Amar, R. K., Sturkenboom, M. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

Inspiratory muscle training in stroke patients with congestive heart failure: A CONSORT-compliant prospective randomized single-blind controlled trial
Conclusion: The 10-week IMT was feasible and effective in improving inspiratory force and activities of daily living for the stroke patients with CHF.
Source: Medicine - September 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

COPD and risk of cardiovascular disease: A prospective study of 0.5M Chinese adults
Conclusions: COPD was independently associated with an increased risk of CV events. COPD detection and management should be integrated with CV disease risk reduction efforts.(Funded by GSK).
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kurmi, O., Li, L., Davis, K., Wang, J., Yang, L., Chen, Y., Guo, Y., Bian, Z., Collins, R., Peto, R., Chen, Z. Tags: 6.1 Epidemiology Source Type: research

Cognitive dysfunction is greater in patients hospitalised with COPD exacerbations than with worsening heart failure
ConclusionsHospitalised COPD patients with exacerbations have greater cognitive impairment than those with worsening heart failure. Differences may be explained by greater smoking load and more anxiety and depression.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bajaj, M., Tappouni, A., Tumilty, M., Dodd, J., Jones, P., Baker, E. Tags: 1.12 Clinical Problems - COPD Source Type: research