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Embolic Strokes and Relapsing Infective Endocarditis Due to Neisseria Subflava (P1.316)
CONCLUSIONS: N.subflava can be a causative agent for relapsing infective endocarditis complicated with embolic strokes. The management of stroke in the setting of IE is different and it is important to be aware of it to avoid complications.Disclosure: Dr. Rodriguez Alvarez has nothing to disclose. Dr. Pillai has nothing to disclose. Dr. Khanna has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rodriguez Alvarez, M., Pillai, A., Khanna, R. Tags: Other Bacterial Infections Source Type: research

Complex decision-making in stroke: preoperative mechanical thrombectomy of septic embolus for emergency cardiac valve surgery
We report a case of cardioembolic stroke in a patient with enterococcal endocarditis, with National Institutes of Health Stroke Scale score of 3. A middle-aged patient with bacterial endocarditis exhibited mild intermittent left hemiparesis and dysarthria in the setting of severe aortic insufficiency requiring urgent aortic valve replacement. Cerebrovascular imaging revealed a partially occlusive thrombus in the M1 segment of the right middle cerebral artery, which became symptomatic during relative hypotension. Given the expected hypotension during the urgently needed aortic valve replacement, there was a significant risk...
Source: Journal of NeuroInterventional Surgery - November 13, 2015 Category: Neurosurgery Authors: Ladner, T. R., Davis, B. J., He, L., Kirshner, H. S., Froehler, M. T., Mocco, J. Tags: Electronic pages Source Type: research

Clinical Presentation of Native Mitral Valve Infective Endocarditis Determines Long‐Term Outcome after Surgery
ConclusionsLong‐term survival after surgery for native mitral valve IE was independently influenced by the presence of preoperative embolic stroke, congestive heart failure or uncontrolled bacteremia alone, or in combination.
Source: Journal of Cardiac Surgery - June 1, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Sigurdur Ragnarsson, Johan Sjögren, Martin Stagmo, Per Wierup, Shahab Nozohoor Tags: Original Article Source Type: research

Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)
Conclusion Rheumatic heart disease patients were young, predominantly female, and had high prevalence of major cardiovascular complications. There is suboptimal utilization of secondary antibiotic prophylaxis, oral anti-coagulation, and contraception, and variations in the use of percutaneous and surgical interventions by country income level.
Source: European Heart Journal - May 7, 2015 Category: Cardiology Authors: Zuhlke, L., Engel, M. E., Karthikeyan, G., Rangarajan, S., Mackie, P., Cupido, B., Mauff, K., Islam, S., Joachim, A., Daniels, R., Francis, V., Ogendo, S., Gitura, B., Mondo, C., Okello, E., Lwabi, P., Al-Kebsi, M. M., Hugo-Hamman, C., Sheta, S. S., Haile Tags: Valvular heart disease Source Type: research

Surgical management of infective endocarditis: an analysis of early and late outcomes ADULT CARDIAC
CONCLUSIONS Surgical management of endocarditis continues to be challenging and is associated with significant morbidity and mortality. This report of 191 patients who underwent valve surgery for IE shows that in-hospital mortality is influenced by preoperative renal function and stroke at the time of presentation. The optimal timing for surgery in patients with stroke remains controversial. Long-term survival was negatively influenced by increasing age, moderate to severely impaired LVEF, prosthetic valve IE and S. aureus infection.
Source: European Journal of Cardio-Thoracic Surgery - April 9, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Pang, P. Y. K., Sin, Y. K., Lim, C. H., Tan, T. E., Lim, S. L., Chao, V. T. T., Chua, Y. L. Tags: Cardiac - other, Valve disease ADULT CARDIAC Source Type: research

Stroke is not a treatment dilemma for early valve surgery in active infective endocarditis.
CONCLUSION: Surgery for AIE with cerebral septic embolisms can be performed safely, with good early and mid-term follow-up results. When urgent or emergent surgery for AIE is needed, neurologic complications should not be a reason for delay. PMID: 25799711 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 25, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Aortic infective endocarditis: Value of surgery. About 48 cases.
CONCLUSION: The prognosis of infective endocarditis of the aortic valve is severe due to the fast progression to heart failure. Early medical and surgical approach provides good results on morbidity and mortality in the short- and mid-terms. PMID: 25813653 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - March 23, 2015 Category: Cardiology Authors: Tribak M, Konaté M, Elhassani A, Mahfoudi L, Jaabari I, Elkenassi F, Boutayeb A, Lachhab F, Filal J, Maghraoui A, Bensouda A, Marmade L, Moughil S Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Efficacy of nafamostat mesilate as anticoagulation during cardiopulmonary bypass for early surgery in patients with active infective endocarditis complicated by stroke.
CONCLUSION: Nafamostat mesilate, administered in conjunction with low-dose heparinization, served as an effective anticoagulant for early surgery in patients with AIE complicated by stroke, and caused no further deterioration of the cerebral lesions. PMID: 25790622 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 21, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Have antibiotic changes upped heart infections?
Conclusion This is valuable and timely research, which has looked at trends before and after NICE's 2008 guidance on the prevention of infective endocarditis in people undergoing invasive procedures. This examined: changes in the prescription of antibiotics for the prevention of infective endocarditis changes in the number of cases of infective endocarditis diagnosed NICE's recommendation was based on an examination of the evidence of the effectiveness of antibiotics in preventing infective endocarditis, weighing the benefits and health outcomes (such as reduction in illness and deaths), risks and costs.   The ...
Source: NHS News Feed - November 19, 2014 Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

Global and Regional Burden of Infective Endocarditis, 1990–2010 A Systematic Review of the Literature
Publication date: March 2014 Source:Global Heart, Volume 9, Issue 1 Author(s): Aref A. Bin Abdulhak , Larry M. Baddour , Patricia J. Erwin , Bruno Hoen , Vivian H. Chu , George A. Mensah , Imad M. Tleyjeh Infective endocarditis (IE) is a life-threatening disease associated with serious complications. The GBD 2010 (Global Burden of Disease, Injuries, and Risk Factors) study IE expert group conducted a systematic review of IE epidemiology literature to inform estimates of the burden on IE in 21 world regions in 1990 and 2010. The disease model of IE for the GBD 2010 study included IE death and 2 sequelae: stroke and valve ...
Source: Global Heart - November 13, 2014 Category: Cardiology Source Type: research

297 * early and late outcomes of complex aortic root surgery in patients with aortic root abscesses
Conclusion: The surgical treatment of aortic root abscess is a challenging operation and is associated with a high early morbidity and mortality. However, the long-term survival is satisfactory.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Davierwala, P. M., Leontyev, S., Gunter, K., Bakhtiary, F., Borger, M., Misfeld, M., Mohr, F., Davierwala, P. Tags: Infective endocarditis and outcomes Source Type: research

300 * influence of different pacemaker stimulation modes in patients with ventricular hypertrophy
Conclusion: An increase in the heart rate does not lead to a notable drop in stroke volume postoperatively in left-ventricular hypertrophy; hence a rise in cardiac output can be anticipated up to a rate of 100 bpm. A standardised response in terms of an ideal pacemaker stimulation mode could not be identified.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kiessling, A. H., Elhadouchi, L., Miskovic, A., Reyher, C., Stock, U. A., Moritz, A. Tags: Infective endocarditis and outcomes Source Type: research

302 * full sternotomy versus right anterior mini-thoracotomy for isolated aortic valve replacement in octogenarians: a propensity matched study
Conclusion: Minimally invasive AVR through RAMT can be safely performed in patients aged ≥80 years with acceptable morbidity and mortality rates. It is an expeditious and effective alternative to full sternotomy AVR and might be associated with lower stroke incidence.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Gilmanov, D. S., Farneti, P. A., Ferrarini, M., Santarelli, F., Murzi, M., Miceli, A., Solinas, M., Glauber, M. Tags: Infective endocarditis and outcomes Source Type: research

Dental implants in patients at high risk for infective endocarditis: a preliminary study
Abstract: The safety of dental implant placement in patients at high risk for infective endocarditis (IE) has never been shown. The outcome of osseointegrated implants in patients with artificial heart valves or with a history of an infected valve is not known. In this article we describe our experience of dental implant placement in patients at high risk for IE. A retrospective study was conducted on patients at high risk for IE who underwent dental implant placement. All the patients received prophylactic antibiotic treatment before the surgical procedure, in accordance with the relevant American Heart Association guidel...
Source: International Journal of Oral and Maxillofacial Surgery - June 2, 2014 Category: ENT & OMF Authors: M. Findler, T. Chackartchi, E. Regev Tags: Oral Medicine Source Type: research

Profile of infective endocarditis observed from 2003 - 2010 in a single center in Italy
Conclusion: S. aureus emerged as the leading causative organism of IE in a University hospital in northern Italy. Our study confirmed the high in-hospital mortality of IE, particularly if health-care associated, and the protective role of surgery.
Source: BMC Infectious Diseases - November 15, 2013 Category: Infectious Diseases Authors: Laurenzia FerrarisLaura MilazzoDavide RicaboniCristina MazzaliGiovanna OrlandoGiuliano RizzardiniMarco CicardiFerdinando RaimondiLoredana TocalliAlessandro CialfiPaolo VanelliMassimo GalliCarlo AntonaSpinello Antinori Source Type: research

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