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Therapy: Hormone Replacement Therapy

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Total 161 results found since Jan 2013.

Whether the use of unopposed oestrogen following a myocardial infarction is beneficial or harmful remains unclear, and in individual women the effects may vary according to the underlying risk profile
Commentary on: Cherry N, McNamee R, Heagerty A, et al.. Long-term safety of unopposed oestrogen used by women surviving myocardial infarction: a 14-year follow-up of the ESPRIT randomised controlled trial. BJOG 2014;121:700–5; discussion 705. Context There is a biological and epidemiological evidence to suggest that high oestrogen levels retard the progression of atherogenesis, reducing the risk of myocardial infarction. Whether such an effect is evident following a first myocardial infarction is unclear. A randomised controlled trial was carried out to investigate. Following completion of the trial the authors conti...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Shapiro, S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Contraception, Drugs: obstetrics and gynaecology, Ischaemic heart disease, Vulvovaginal disorders Harm Source Type: research

Primary Ovarian Insufficiency
Abstract Primary ovarian insufficiency (POI) is a syndrome of amenorrhoea, sex steroid deficiency, and elevated gonadotropins in a woman aged more than two standard deviations below the mean age for menopause estimated for her reference population. In practical terms, it occurs spontaneously in 1 % of women before the age of 40 years. Apart from idiopathic POI, many women will have impaired ovarian function by age 40 years as a consequence of surgery, chemotherapy, or radiotherapy. Of identifiable causes of POI, the most common are concurrent autoimmune diseases such as thyroid and adrenal disease, and chromoso...
Source: Current Obstetrics and Gynecology Reports - September 3, 2014 Category: OBGYN Source Type: research

Female sex as a risk factor for thromboembolism and death in patients with incident atrial fibrillation. The prospective Danish Diet, Cancer and Health study.
In conclusion, in a relatively young population of patients with atrial fibrillation, female sex was associated with a lower risk of thromboembolism and death. PMID: 25055988 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 24, 2014 Category: Hematology Authors: Overvad TF, Rasmussen LH, Skjøth F, Overvad K, Albertsen IE, Lane DA, Lip GY, Larsen TB Tags: Thromb Haemost Source Type: research

The effect of growth hormone replacement therapy on the morphological and functional changes in the left ventricle in patients with adult-onset growth hormone deficiency.
CONCLUSION: A mild increase in LVM and improvement of LVEF accompanies long-term GH replacement therapy. The effect on LV morphology is more pronounced in men than in women. PMID: 24981406 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - July 1, 2014 Category: Journals (General) Authors: Dlesk A, Kamenský G, Lazúrová I, Kužma M, Payer J Tags: Wien Klin Wochenschr Source Type: research

Plasma Levels of the Proinflammatory Chitin-Binding Glycoprotein YKL-40, Variation in the Chitinase 3-Like 1 Gene (CHI3L1), and Incident Cardiovascular Events Epidemiology
Conclusions Among initially healthy U.S. women, plasma levels of the proinflammatory chitenase-like protein, YKL-40, were influenced by environmental as well as genetic factors and predicted incident thromboembolic stroke, but not MI, a differential effect consistent with limited previous data.
Source: JAHA:Journal of the American Heart Association - June 23, 2014 Category: Cardiology Authors: Ridker, P. M., Chasman, D. I., Rose, L., Loscalzo, J., Elias, J. A. Tags: Epidemiology Source Type: research

Hormone replacement therapy in menopause
Embora o estrógeno já esteja disponível para venda há mais de seis décadas, as mulheres ainda permanecem confusas quanto ao risco e aos benefícios da terapia hormonal na menopausa (THM), terapia estrogênica isolada ou associada a progestágenos. A publicação de estudos controlados, randomizados, como o Heart and Estrogen/progestin Replacement Study (HERS) e Women’s Health Initiative (WHI), intensificou essa controvérsia risco/benefício. Milhares de mulheres são tratadas com THM para alívio dos sintomas menopausais, incluindo sintomas vasomotores e sudorese, principal indicação da estrogenoterapia. Outras p...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - May 14, 2014 Category: Endocrinology Source Type: research

Cardiovascular benefits of HRT may differ by patient age
Commentary on: Main C, Knight B, Moxham T, et al.. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev 2013;(4):CD002229. Context In early postmenopausal women oestrogen and/or hormone replacement therapy (ERT/HRT) are used to alleviate symptoms and reduce the probability of diseases related to ovarian hormones deprivation. However, in late postmenopausal women the initiation of HRT has a negative risk/benefit balance mainly because of the increased risk of cardiovascular diseases (CVD). Methods Main et al performed a meta-analysis of randomised controlled trials (RCTs...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Rosano, G., Vitale, C. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Contraception, Drugs: obstetrics and gynaecology, Menopause (including HRT), Interventional cardiology, Ischaemic heart disease, Venous thromboembolism, Radiology Source Type: research

Moderate Exercise Cuts Women's Stroke Risk, Helps Offset Increase Risk from Hormone Therapy
Source: American Heart Association Related MedlinePlus Pages: Hormone Replacement Therapy, Stroke
Source: MedlinePlus Health News - February 14, 2014 Category: Consumer Health News Source Type: news

Menopause and weight gain
Many women approaching the menopause will experience a number of symptoms, including vaginal dryness, hot flushes and a lack of sex drive. However another symptom that may arise as a result of the menopause is weight gain. Most commonly occurring around the hips and abdomen, this menopausal symptom for the majority of women is considered to be the least desirable. Although the exact factors that contribute to weight gain are not entirely understood, it is known that a decline in oestrogen levels, a loss of muscle tissue and lifestyle factors are part of the cause. Though it can be argued that a slight increase in weight i...
Source: The Hysterectomy Association - November 7, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health hormone replacement therapy oestrogen weight gain Source Type: news

Menopause and Weight Gain
Many women approaching the menopause will experience a number of symptoms, including vaginal dryness, hot flushes and a lack of sex drive. However another symptom that may arise as a result of the menopause is weight gain. Most commonly occurring around the hips and abdomen, this menopausal symptom for the majority of women is considered to be the least desirable. Photo: Nikodem Nijaki: Wikipedia Although the exact factors that contribute to weight gain are not entirely understood, it is known that a decline in oestrogen levels, a loss of muscle tissue and lifestyle factors are part of the cause. Though it can be argued t...
Source: The Hysterectomy Association - November 7, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: menopause hormone replacement therapy oestrogen weight gain Source Type: news

Still a place for hormone replacement therapy?
Abstract Hormone replacement therapy (HRT) remains the most efficient treatment to alleviate climacteric symptoms. The drastic decline in their prescription following the WHI is not fully justified. Benefits might be more important than harm in women 50-60 years. French way of treatment does not increase the risk in thrombosis nor stroke and breast cancer risk is less important than with other regimen. One of the major benefits of HRT is the decrease in type 2 diabetes with all the treatments including the French ones. The results of the American randomized trials cannot be fully extrapolated to young postmenopa...
Source: Presse Medicale - November 7, 2013 Category: Journals (General) Authors: Gompel A Tags: Presse Med Source Type: research

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life
Objectives:We assessed whether hypertension in pregnancy is associated with elevated C-reactive protein (CRP) levels in later life, possibly reflecting an increased risk of cardiovascular disease (CVD). Background:Elevated CRP levels have been associated with hypertension in pregnancy and with CVD. Methods:We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Participants were categorized as nulliparous women (n = 219), women with a history of normotensive pregnancies (n = 1839), or women with a history of a hypertensive pregnancy (n = 405). Using multiple linear regression ...
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Pregnancy Source Type: research

Different risks for heart attack and stroke posed by different hormone therapy formulations
Post-menopausal women whose doctors prescribe hormone replacement therapy for severe hot flashes and other menopause symptoms may want to consider taking low doses of Food and Drug Administration-approved bioidentical forms of estrogen or getting their hormones via a transdermal patch. A new observational study shows bioidentical hormones in transdermal patches may be associated with a lower risk of heart attack and FDA-approved products -- not compounded hormones -- may be associated with a slightly lower risk of stroke compared to synthetic hormones in pill form...
Source: Health News from Medical News Today - September 20, 2013 Category: Consumer Health News Tags: Menopause Source Type: news