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Procedure: Perfusion
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Total 22 results found since Jan 2013.
Robot-assisted mechanical therapy attenuates stroke-induced limb skeletal muscle injury Research
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted mechanical therapy (RAMT) device to objectively address the significance of mechanical physiotherapy on poststroke outcomes. Wistar rats were subjected to right hemisphere middle-cerebral artery occlusion and reperfusion. After 24 h, rats were split into control (RAMT–) or RAMT+ groups (30 min daily RAMT over the stroke-affected gastrocnemius) and were followed up to postst...
Source: FASEB Journal - February 27, 2017 Category: Biology Authors: Sen, C. K., Khanna, S., Harris, H., Stewart, R., Balch, M., Heigel, M., Teplitsky, S., Gnyawali, S., Rink, C. Tags: Research Source Type: research
The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output RESEARCH ARTICLE
Morten Smerup, Mads Damkjaer, Emil Brondum, Ulrik T. Baandrup, Steen Buus Kristiansen, Hans Nygaard, Christian Aalkjaer, Cathrine Sauer, Rasmus Buchanan, Mads Frost Bertelsen, Kristine Ostergaard, Carsten Grondahl, Geoffrey Candy, J. Michael Hasenkam, Niels H. Secher, Peter Bie, and Tobias WangGiraffes – the tallest extant animals on Earth – are renowned for their high central arterial blood pressure, which is necessary to secure brain perfusion. The pressure which may exceed 300 mmHg has historically been attributed to an exceptionally large heart. Recently, this has been refuted by several studies demonstrati...
Source: Journal of Experimental Biology - December 7, 2015 Category: Biology Authors: Smerup, M., Damkjaer, M., Brondum, E., Baandrup, U. T., Kristiansen, S. B., Nygaard, H., Aalkjaer, C., Sauer, C., Buchanan, R., Bertelsen, M. F., Ostergaard, K., Grondahl, C., Candy, G., Hasenkam, J. M., Secher, N. H., Bie, P., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model
Publication date: Available online 4 July 2019Source: Journal of Thermal BiologyAuthor(s): Yannick Lutz, Axel Loewe, Stephan Meckel, Olaf Dössel, Giorgio CattaneoAbstractLocal brain hypothermia is an attractive method for providing cerebral neuroprotection for ischemic stroke patients and at the same time reducing systemic side effects of cooling. In acute ischemic stroke patients with large vessel occlusion, combination with endovascular mechanical recanalization treatment could potentially allow for an alleviation of inflammatory and apoptotic pathways in the critical phase of reperfusion. The direct cooling of arterial...
Source: Journal of Thermal Biology - July 6, 2019 Category: Biology Source Type: research
Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts RESEARCH ARTICLE
William Joyce, Michael Axelsson, and Tobias Wang Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtle more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trac...
Source: Journal of Experimental Biology - February 20, 2019 Category: Biology Authors: Joyce, W., Axelsson, M., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning
Publication date: 2014 Source:Redox Biology, Volume 2 Author(s): Theodore Kalogeris , Yimin Bao , Ronald J. Korthuis Reductions in the blood supply produce considerable injury if the duration of ischemia is prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue damage and extend the size of an evolving infarct. Being highly metabolic organs, the heart and brain are particularly vulnerable to the deleterious effects of ischemia/reperfusion (I/R). While the pathogenetic mechanisms contributing to I/R-induced tissue injury and infarction are multifactorial, the relative importance of eac...
Source: Redox Biology - October 12, 2014 Category: Biology Source Type: research
Dynamics of blood circulation during diving in the bottlenose dolphin (Tursiops truncatus): the role of the retia mirabilia RESEARCH ARTICLE
Marco Bonato, Paola Bagnoli, Cinzia Centelleghe, Mike Maric, Ginevra Brocca, Sandro Mazzariol, and Bruno Cozzi
The retia mirabilia are vascular nets composed of small vessels dispersed among numerous veins, allowing blood storage, regulation of flow and pressure damping effects. Here, we investigated their potential role during the diving phase of the bottlenose dolphin (Tursiops truncatus). To this effect, the whole vertebral retia mirabilia of a series of dolphins were removed during post-mortem analysis and examined to assess vessel diameters, and estimate vascular volume and flow rate. We formulated a new hemodynamic ...
Source: Journal of Experimental Biology - March 6, 2019 Category: Biology Authors: Bonato, M., Bagnoli, P., Centelleghe, C., Maric, M., Brocca, G., Mazzariol, S., Cozzi, B. Tags: RESEARCH ARTICLE Source Type: research
Coronary blood flow influences tolerance to environmental extremes in fish RESEARCH ARTICLE
Daniel Morgenroth, Tristan McArley, Albin Gräns, Michael Axelsson, Erik Sandblom, and Andreas Ekström Approximately half of all fishes have, in addition to the luminal venous O2 supply, a coronary circulation supplying the heart with fully oxygenated blood. Yet, it is not fully understood how coronary O2 delivery affects tolerance to environmental extremes such as warming and hypoxia. Hypoxia reduces arterial oxygenation, while warming increases overall tissue O2 demand. Thus, as both stressors are associated with reduced venous O2 supply to the heart, we hypothesised that coronary flow benefits hypoxia and...
Source: Journal of Experimental Biology - March 9, 2021 Category: Biology Authors: Morgenroth, D., McArley, T., Gräns, A., Axelsson, M., Sandblom, E., Ekström, A. Tags: RESEARCH ARTICLE Source Type: research
Winter metabolic depression does not change arterial baroreflex control of heart rate in the tegu lizard (Salvator merianae) RESEARCH ARTICLE
Lucas A. Zena, Valter Dantonio, Luciane H. Gargaglioni, Denis V. Andrade, Augusto S. Abe, and Kenia C. BicegoBaroreflex regulation of blood pressure (BP) is important for maintaining appropriate tissue perfusion. Although temperature affects heart rate (fH) reflex regulation in some reptiles and toads, no data are available on the influence of temperature-independent metabolic states on baroreflex. The South American tegu lizard Salvator merianae exhibits a clear seasonal cycle of activity decreasing fH along with winter metabolic downregulation, independent of body temperature. Through pharmacological interventions (pheny...
Source: Journal of Experimental Biology - January 8, 2016 Category: Biology Authors: Zena, L. A., Dantonio, V., Gargaglioni, L. H., Andrade, D. V., Abe, A. S., Bicego, K. C. Tags: RESEARCH ARTICLE Source Type: research
Winter metabolic depression does not change arterial baroreflex control of heart rate in the tegu lizard Salvator merianae RESEARCH ARTICLE
Lucas A. Zena, Valter Dantonio, Luciane H. Gargaglioni, Denis V. Andrade, Augusto S. Abe, and Kenia C. Bicego
Baroreflex regulation of blood pressure is important for maintaining appropriate tissue perfusion. Although temperature affects heart rate (fH) reflex regulation in some reptiles and toads, no data are available on the influence of temperature-independent metabolic states on baroreflex. The South American tegu lizard Salvator merianae exhibits a clear seasonal cycle of activity decreasing fH along with winter metabolic downregulation, independent of body temperature. Through pharmacological interventions (phenyleph...
Source: Journal of Experimental Biology - March 2, 2016 Category: Biology Authors: Zena, L. A., Dantonio, V., Gargaglioni, L. H., Andrade, D. V., Abe, A. S., Bicego, K. C. Tags: RESEARCH ARTICLE Source Type: research
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization
by Niklas H übel, Mahshid S. Hosseini-Zare, Jokūbas Žiburkus, Ghanim Ullah
Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on eluc idating the molecular and cellular pathways involved in these mostly interdependent variations. In this paper, we develop the first computational framework that combines the Hodgkin–Huxley type spiking dynamics, dynamic ion concentrations and glutama...
Source: PLoS Computational Biology - October 12, 2017 Category: Biology Authors: Niklas H übel Source Type: research
Analysis of vascular mechanical properties from the yellow anaconda indicates increased elasticity and distensibility of the pulmonary artery during digestion RESEARCH ARTICLE
Renato Filogonio, Tobias Wang, and Carl Christian Danielsen In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few exceptions among non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressures to both circuits. This raises the question whether in these species ...
Source: Journal of Experimental Biology - June 25, 2018 Category: Biology Authors: Filogonio, R., Wang, T., Danielsen, C. C. Tags: RESEARCH ARTICLE Source Type: research
