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Dual-modality imaging of endothelial progenitor cells transplanted after ischaemic photothrombotic stroke
Publication date: Available online 2 November 2019Source: Life SciencesAuthor(s): Jie Ding, Yi Zhang, Cong-Xiao Wang, Pei-Cheng Li, Zhen Zhao, Chao Wang, Gao-Jun TengAbstractAimsStroke is a refractory cerebral blood circulation disorder. Endothelial progenitor cells (EPCs) participate in the repair and regeneration of vascular injury through the combination of cell replacement and bystander effects. Here, we evaluated the biological function of EPCs in treating a mouse model of cerebral ischaemic stroke, using dual-mode bioluminescence and magnetic resonance imaging to trace EPCs in vivo.Main methodsWe constructed a viral ...
Source: Life Sciences - November 4, 2019 Category: Biology Source Type: research

Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model
This study aims to explore the role of fractalkine/CX3C chemokine receptor 1 (CX3CR1) signaling pathway in the recovery of neurological functioning after an early ischemic stroke in rats. After establishment of permanent middle cerebral artery occlusion (pMCAO) models, 50 rats were divided into blank, sham, model, positive control and CX3CR1 inhibitor groups. Neurological impairment, walking and grip abilities, and cortical and hippocampal infarctions were evaluated by Zea Longa scoring criterion, beam-walking assay and grip strength test, and diffusion-weighted magnetic resonance imaging. qRT-PCR and Western blotting were...
Source: Life Sciences - July 19, 2017 Category: Biology Source Type: research

Diffusion Magnetic Resonance Imaging: What Water Tells Us about Biological Tissues
by Denis Le Bihan, Mami Iima Since its introduction in the mid-1980s, diffusion magnetic resonance imaging (MRI), which measures the random motion of water molecules in tissues, revealing their microarchitecture, has become a pillar of modern neuroimaging. Its main clinical domain has been the diagnosis of acute brain stroke and neurogical disorders, but it is also used in the body for the detection and management of cancer lesions. It can also produce stunning maps of white matter tracks in the brain, with the potential to aid in the understanding of some psychiatric disorders. However, in order to exploit fully the pote...
Source: PLoS Biology: Archived Table of Contents - July 23, 2015 Category: Biology Authors: Denis Le Bihan et al. Source Type: research

Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
ConclusionsMetabolic syndrome was associated with brain ischemic lesions in men but not in women. Higher body mass index was related to ischemic lesions located in lobar in men and in deep brain/infratentorial areas in women. Its mechanisms remain to be further investigated.
Source: Biology of Sex Differences - August 21, 2019 Category: Biology Source Type: research

Magnetic Resonance Imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) SHORT COMMUNICATION
Catherine J. A. Williams, Eva M. Greunz, Steffen Ringgaard, Kasper Hansen, Mads F. Bertelsen, and Tobias Wang The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here we use the gold standard clinical methodology – electrocardiogram (ECG) gated flow magnetic resonance imaging (MRI) – to validate stroke volume measurements and end diastolic ventricular blood volumes. This produces an estimate of ejection fraction in the red footed tortoise Chelonoidis carbonaria (n=5) under isoflurane anaesthesia of 88±11%. After elimination of the prevailing right-to-...
Source: Journal of Experimental Biology - August 21, 2019 Category: Biology Authors: Williams, C. J. A., Greunz, E. M., Ringgaard, S., Hansen, K., Bertelsen, M. F., Wang, T. Tags: SHORT COMMUNICATION Source Type: research

Magnetic resonance imaging (MRI) reveals high cardiac ejection fractions in red-footed tortoises (Chelonoidis carbonarius) SHORT COMMUNICATION
Catherine J. A. Williams, Eva M. Greunz, Steffen Ringgaard, Kasper Hansen, Mads F. Bertelsen, and Tobias Wang The ejection fraction of the trabeculated cardiac ventricle of reptiles has not previously been measured. Here, we used the gold standard clinical methodology – electrocardiogram-gated flow magnetic resonance imaging (MRI) – to validate stroke volume measurements and end diastolic ventricular blood volume. This produced an estimate of ejection fraction in our study species, the red footed tortoise Chelonoidis carbonarius (n=5), under isoflurane anaesthesia of 88±11%. After reduction of the preva...
Source: Journal of Experimental Biology - September 15, 2019 Category: Biology Authors: Williams, C. J. A., Greunz, E. M., Ringgaard, S., Hansen, K., Bertelsen, M. F., Wang, T. Tags: SHORT COMMUNICATION Source Type: research

Therapeutic Nuclear Magnetic Resonance affects the core clock mechanism and associated Hypoxia-inducible factor-1
Chronobiol Int. 2021 Apr 13:1-15. doi: 10.1080/07420528.2021.1910288. Online ahead of print.ABSTRACTThe influence of low intensity electromagnetic fields on circadian clocks of cells and tissues has gained increasing scientific interest, either as a therapeutic tool or as a potential environmental hazard. Nuclear Magnetic Resonance (NMR) refers to the property of certain atomic nuclei to absorb the energy of radio waves under a corresponding magnetic field. NMR forms the basis for Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and, in a low-intensity form, for NMR therapy (tNMR). Since the circadian clock is b...
Source: Chronobiology International - April 13, 2021 Category: Biology Authors: Viktoria Th öni Regina Oliva David Mauracher Margit Egg Source Type: research