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Predicting in a predicament: Stroke and hemorrhage risk prediction in dialysis patients with atrial fibrillation
Abstract Whether to anticoagulate dialysis patients with atrial fibrillation is a common clinical dilemma with limited high‐quality data to inform decision‐making. While the efficacy and safety of anticoagulation for stroke prevention in dialysis patients with atrial fibrillation has long been debated and remains unclear, the more upstream issue of stroke risk assessment from atrial fibrillation has received relatively little attention. In the general population, a handful of risk scores to help predict stroke and hemorrhage risk in the setting of atrial fibrillation are widely validated and applied in clinical practic...
Source: Seminars In Dialysis - July 1, 2017 Category: Hematology Authors: Amber O. Molnar, Manish M. Sood Tags: REVIEW ARTICLE Source Type: research

Evidence for the Prevention and Treatment of Stroke in Dialysis Patients
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well‐conducted randomized trials are not susceptible to such biases and can reliably investigate t...
Source: Seminars In Dialysis - May 1, 2014 Category: Hematology Authors: William Herrington, Richard Haynes, Natalie Staplin, Jonathan Emberson, Colin Baigent, Martin Landray Tags: Review Source Type: research

Cardiovascular and Stroke Risk in Japanese Hemodialysis Patients With Atrial Fibrillation
Abstract Atrial fibrillation is one of the most common arrhythmias in hemodialysis patients. We evaluated its clinical outcomes among hemodialysis patients with atrial fibrillation in Japan. Using data derived from the Japanese Dialysis Outcomes and Practice Patterns Study, we analyzed backgrounds and outcomes among hemodialysis patients with and without atrial fibrillation in Japan. Among 7002 hemodialysis patients, the prevalence of atrial fibrillation was 5.7% and the incidence was 0.2 per 100 patient‐years. Atrial fibrillation was independently associated with all‐cause mortality (hazard ratio, 1.32; 95% confidence...
Source: Therapeutic Apheresis and Dialysis - September 30, 2016 Category: Hematology Authors: Jumpei Hasegawa, Brian Bieber, Maria Larkina, Bruce M. Robinson, Sachiko Wakai, Tadao Akizawa, Akira Saito, Shunichi Fukuhara, Takashi Akiba Tags: Original Article Source Type: research

Association of blood pressure with all‐cause mortality and stroke in Japanese hemodialysis patients: The Japan dialysis outcomes and practice pattern study
Abstract The association of low blood pressure (BP) with high mortality is a characteristic for hemodialysis patients. This analysis clarifies the association of BP with mortality and stroke in Japanese hemodialysis (HD) patients and examines the association separately for patients with and without antihypertensive medication (BP meds). We analyzed 9134 patients from Japan in phases 1–4 (1999–2011) of the Dialysis Outcomes and Practice Patterns Study (DOPPS), a prospective cohort study of in‐center HD patients. The association of patient systolic (SBP) and diastolic (DBP) blood pressure with all‐cause and cause‐s...
Source: Hemodialysis International - January 1, 2014 Category: Hematology Authors: Masaaki Inaba, Angelo Karaboyas, Takashi Akiba, Tadao Akizawa, Akira Saito, Shunichi Fukuhara, Christian Combe, Bruce M. Robinson Tags: Original Article Source Type: research

High Stroke Volume Variation Is an Independent Predictor for Decreased Blood Pressure During Hemodialysis
Abstract It currently remains unclear whether stroke volume variation (SVV) before hemodialysis (HD) is an independent predictor of decreased blood pressure (BP) during HD. Fifty‐two patients were divided into two groups (Decreased BP during HD group: N = 10, Non‐decreased BP group: N = 42). Fractional shortening was lower, and mean arterial pressure (MAP) and SVV were higher in the Decreased BP during HD group. A multiple logistic regression analysis identified low fractional shortening, high MAP, and high SVV as independent predictors of decreased BP during HD. The areas under the ROC curves were as follows: 0.84...
Source: Therapeutic Apheresis and Dialysis - March 9, 2017 Category: Hematology Authors: Fumiki Yoshihara, Masatsugu Kishida, Koji Ogawa, Takayuki Nishigaki, Hironori Nakasaki, Azusa Ishizuka, Ryo Koezuka, Miki Matsuo, Teruyuki Hayashi, Satoko Nakamura Tags: Original Article Source Type: research

Cardiovascular and renal outcomes in patients with atrial fibrillation and stage 4 –5 chronic kidney disease receiving direct oral anticoagulants: a multicenter retrospective cohort study
AbstractThe role of direct oral anticoagulants (DOAC) in patients with atrial fibrillation (AF) and stage 4 –5 chronic kidney disease (CKD) is controversial. Electronic medical records from 2012 to 2021 were retrieved for patients with AF and stage 4–5 CKD receiving oral anticoagulants. Patients were separated into those receiving DOACs (dabigatran, rivaroxaban, apixaban, or edoxaban) or vitamin K ant agonists (VKA). Primary outcomes included ischemic stroke (IS), systemic thrombosis (SE), major bleeding, gastrointestinal bleeding, hemorrhagic stroke, acute myocardial infarction, cardiovascular death, and all-cause dea...
Source: Journal of Thrombosis and Thrombolysis - August 21, 2023 Category: Hematology Source Type: research

Higher Mortality Due to Intracerebral Hemorrhage in Dialysis Patients: A Comparison with the General Population in Japan
Abstract Cerebrovascular diseases, including intracerebral hemorrhage, cerebral infarction, and subarachnoid hemorrhage, remain prevalent causes of morbidity and mortality among dialysis patients. Their mortality rate for cerebrovascular diseases is roughly three times higher than that in the general population. However, whether mortality rates for all subtypes of cerebrovascular diseases are equally higher has not been evaluated. The aim of this study was to determine the mortality rate for each stroke subtype, comparing dialysis patients and the general population in Japan. We used mortality data reported by the Japanese...
Source: Therapeutic Apheresis and Dialysis - September 4, 2014 Category: Hematology Authors: Minako Wakasugi, Koji Matsuo, Junichiro James Kazama, Ichiei Narita Tags: Original Article Source Type: research

Prevalence and correlates of functional dependence among maintenance dialysis patients
Abstract Functional dependence is an important determinant of longevity and quality of life. The purpose of the current study was to determine the prevalence and correlates of functional dependence among patients with end‐stage renal disease (ESRD) receiving maintenance dialysis. We enrolled 148 participants with ESRD from five clinics. Functional status, as measured by basic and instrumental activities of daily living (ADL, IADL), was ascertained by validated questionnaires. Functional dependence was defined as needing assistance in at least one of seven IADLs or at least one of four ADLs. Demographic characteristics, c...
Source: Hemodialysis International - March 2, 2015 Category: Hematology Authors: Niall T. Kavanagh, Brigitte Schiller, Anjali B. Saxena, I‐Chun Thomas, Manjula Kurella Tamura Tags: Original Article Source Type: research

Comparison between Automated Erythrocytopharesis (AECP) and Manual Exchange Transfusion (M-Ex)) in Reducing Hb-S and in Recovery of Acute Chest Syndrome and Other Acute Presentations of Sickle Cell Disease Patients
Conclusions:Erythrocytopharesis (Automated RBC exchange) is effective, quick and safe procedure that is life saving for many patients with ACS and is associated with less difficulties and complications if compared with the manual exchange. Because SCA is a national problem in Saudi Arabia and acute chest syndrome and other acute major complications comprehensively kill SCD patients, Automated Erythocytopharesis should be available nation-wide like dialysis machines at all large hospitals in all cities and should be distributed according to the prevalence of SCA in the area or location.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ahmed, S. Y., Saleh, S. M., Hameed, M. S., Ragheb, A. M., Abbas, T. M., Fadel, A., Hassan, S., Baden, H. S., Tayeb, K. I., Bakshi, N., El Yamany, G., Alotaibi, S. B. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical Source Type: research

Thrombotic Thrombocytopenic Purpura in Oman; Manifestations and Outcome. Retrospective Study
Conclusion:This is the first study that demonstrates the demographic, clinical and survival rate of TTP patients in Oman, and provides a general picture of the TTP patients in our countryDisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Al Hashmi, K. N., Al Dowaiki, S. Tags: 311. Disorders of Platelet Number or Function Source Type: research

Clinical Outcomes of Prolonged Antiplatelet Therapy after Percutaneous Coronary Intervention in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis
Conclusions: Prolonged DAPT might decrease the risk of mortality, MACE, and stroke in patients with CKD without any significant difference in bleeding or revascularization. Additional studies are required to determine whether long-term DAPT could be considered for most CKD patients after PCI.Blood Purif
Source: Blood Purification - December 6, 2022 Category: Hematology Source Type: research

Cardiovascular mortality due to pulmonary embolism in subjects with renal impairment: patients’ comorbidities are crucial
Abstract we read with great interest the paper by Ocak et al. (1). The authors found that the age‐ and sex‐standardized mortality rate (SMR) for pulmonary embolism (PE) was 12.2 (95% CI 10.2‐14.6) times higher in dialysis patients than in the general population. Such SMR was even higher than that of myocardial infarction (MI) (11.0, 95% CI 10.6‐11.4), stroke (8.4 (95% CI 8.0‐8.8), and other cardiovascular disease (8.3, 95% CI 8.0‐8.5) On the one hand, the association between the different grade of impaired renal function and MI received important confirmation (2), and also a recent study from our group conducte...
Source: Journal of Thrombosis and Haemostasis - April 4, 2013 Category: Hematology Authors: Fabio Fabbian, Francesco Dentali, Walter Ageno, Roberto Manfredini Tags: Letter Rebuttal Source Type: research

Blood Pressure Recordings During Hemodialysis Access Interventions: Implications for Acute Management
Abstract A retrospective study evaluating the pattern of blood pressure and its related complications before, during, and after percutaneous hemodialysis interventions was performed in patients presenting with asymptomatic hypertension. Hemodialysis patients undergoing percutaneous interventions including tunneled hemodialysis catheter insertion, percutaneous balloon angioplasty and thrombectomy procedure, and stage II hypertension (systolic blood pressure ≥160 mmHg) were included in this analysis. Blood pressure medications were not used while midazolam and fentanyl were routinely administered. Patients were followed f...
Source: Seminars In Dialysis - March 28, 2013 Category: Hematology Authors: Arif Asif, Hector Castro, Ahmed Ameen Waheed, Vishesh Kumar, Syed S Haqqie, Gary Siskin, Roy O Mathew, Darius Mason, Tushar Vachharajani, Ali Nayer, Donna Merrill, Muhammad UT Akmal, Loay Salman Tags: Investigation Source Type: research

Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Abstract: Cardiopulmonary bypass (CPB) during cardiac surgery can involve deliberate hypothermia of the systemic (22-36°C) and coronary circulations (as low as 8-12°C). Adverse sequelae of cold-active antibodies have been feared and reported under such conditions, and some centers thus elect to screen for cold agglutinins before CPB. We reviewed the literature on cold agglutinins in cardiac surgery and described the yields and effects of cold agglutinin screening (CAS) in 14900 cardiac surgery patients undergoing CPB over 8 years at a single institution. Cold agglutinin screening was positive in 47 cases (0.3%), at an an...
Source: Transfusion Medicine Reviews - February 4, 2013 Category: Hematology Authors: Michael D. Jain, Rosa Cabrerizo-Sanchez, Keyvan Karkouti, Terrence Yau, Jacob M. Pendergrast, Christine M. Cserti-Gazdewich Tags: Original Articles Source Type: research

Prospective clinical trial on dosage optimizing of tranexamic acid in non-emergency cardiac surgery procedures.
CONCLUSION: Use of 1 g TxA is safe and sufficient for elective patients with on pump cardiac surgery and thus has been established as strategy of choice in our center. PMID: 24113504 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - October 10, 2013 Category: Hematology Authors: Waldow T, Szlapka M, Haferkorn M, Bürger L, Plötze K, Matschke K Tags: Clin Hemorheol Microcirc Source Type: research

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