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The relation between acute intracerebral hemorrhage and diffusion-weighted imaging lesions: a meta-analysis
AbstractDiffusion-weighted imaging lesions in intracerebral hemorrhage are related to a higher risk of recurrent intracerebral hemorrhage, cognitive damage, and mortality. However, it has been reported that the relationship between the risk of diffusion-weighted imaging lesions and intracerebral hemorrhage subtype or the possible risk factors for diffusion-weighted imaging lesions is variable. This meta-analysis was performed to evaluate this relationship. A systematic literature search up-to August 2020 was performed and 12 studies included 2815 subjects at the baseline with intracerebral hemorrhage. Odds ratio (OR) or me...
Source: Journal of Thrombosis and Thrombolysis - March 30, 2021 Category: Hematology Source Type: research

Oral anticoagulation for patients with atrial fibrillation in the ED: RE-LY AF registry analysis
AbstractOral anticoagulation (OAC) reduces stroke risk in patients with atrial fibrillation (AF). We sought to determine predictors of OAC initiation in AF patients presenting to the emergency department (ED). Secondary analysis of the RE-LY AF registry which enrolled individuals from 47 countries between 2007 and 2011 who presented to an ED with AF and followed them for 1  year. A total of 4149 patients with AF as their primary diagnosis who were not already taking OAC and had a CHA2DS2-VASc  ≥ 1 for men or ≥ 2 for women were included in this analysis. Of these individuals, 26.8% were started on OAC (99.2% vi...
Source: Journal of Thrombosis and Thrombolysis - August 2, 2021 Category: Hematology Source Type: research

Incidence of thrombotic complications related to weight-based dosing of activated prothrombin complex concentrate (aPCC) for reversal of apixaban and rivaroxaban in obese patients
AbstractFactor eight inhibitor bypassing activity (aPCC) is recommended as a non-specific reversal agent for direct oral anticoagulants (DOACs) according to the 2017 American College of Cardiology (ACC) guidelines for reversal of anticoagulation. Factor eight inhibitor bypassing activity carries a black box warning for thrombotic events such as stroke, pulmonary embolism, deep vein thrombosis, and myocardial infarction, particularly at high doses. This was a retrospective, single-center, cohort investigation that included patients who received a weight-based dose of aPCC for reversal of apixaban and rivaroxaban between Jan...
Source: Journal of Thrombosis and Thrombolysis - November 17, 2021 Category: Hematology Source Type: research

Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series
CONCLUSIONS: in the different clinical disorders, the trend of this integrin subunit provides some specific information, useful to select the best therapeutic strategy in clinical practice.PMID:37482987 | DOI:10.3233/CH-231771
Source: Clinical Hemorheology and Microcirculation - July 24, 2023 Category: Hematology Authors: Gregorio Caimi Rosalia Lo Presti Caterina Carollo Maria Montana Melania Carlisi Source Type: research

Relationship between mean platelet volume and mitral annular calcification
Mitral annular calcification (MAC) is associated with several cardiovascular disorders including coronary artery disease (CAD), atherosclerosis, heart failure, and stroke. MAC and atherosclerosis share similar clinical risk factors for cardiovascular diseases, including age, obesity, hypertension, hyperlipidemia, and diabetes mellitus. The aim of this study was to assess the mean platelet volume (MPV), an indicator of platelet activation in patients with MAC. The study group consisted of 101 patients with MAC. An age, sex, and BMI matched control group was composed of 55 patients who were admitted to the echocardiography l...
Source: Blood Coagulation and Fibrinolysis - January 31, 2013 Category: Hematology Tags: Original Articles Source Type: research

The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis
Abstract: Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are consistent on the role of TFPI in arterial thrombosis as they reveal an active role for TFPI in attenuating arterial thrombus formation. In addition, ample experimental evidence exists indicating that TFPI has inhibitory effects on both smooth muscle cell migration and proliferation, both which are re...
Source: Blood Reviews - April 30, 2013 Category: Hematology Authors: Kristien Winckers, Hugo ten Cate, Tilman M. Hackeng Source Type: research

Correlates of ADL difficulty in a large hemodialysis cohort
Abstract Needing assistance with activities of daily living (ADL) is an early indicator of functional decline and has important implications for individuals' quality of life. However, correlates of need for ADL assistance have received limited attention among patients undergoing maintenance hemodialysis (HD). A multicenter cohort of 742 prevalent HD patients was assessed in 2009–2011 and classified as frail, prefrail and nonfrail by the Fried frailty index (recent unintentional weight loss, reported exhaustion, low grip strength, slow walk speed, low physical activity). Patients reported need for assistance with 4 ADL ta...
Source: Hemodialysis International - October 9, 2013 Category: Hematology Authors: Nancy G. Kutner, Rebecca Zhang, Richard M. Allman, C. Barrett Bowling Tags: Original Article Source Type: research

Soluble P-selectin: The next step
It has long been recognised that platelets are implicated in both mortality and morbidity in the pathophysiology of a variety of conditions, including coronary artery disease , diabetes , cancer , stroke , and deep vein thrombosis . The success of aspirin in reducing thrombotic events, and the prognostic value of platelet volume, numbers and function in predicting cardiovascular death are further evidence of the importance of this cell. Consequently, the ability to accurately identify those subjects at risk of thrombosis, and possibly those experiencing an acute thrombotic event, is highly sought-after if risk reduction an...
Source: Thrombosis Research - November 11, 2013 Category: Hematology Authors: Andrew D. Blann Tags: Editorials Source Type: research

Association between neutrophil–lymphocyte ratio and mitral annular calcification
Mitral annular calcification (MAC) is closely related to cardiovascular disorders including coronary artery disease, atherosclerosis, heart failure, and stroke. The clinical risk factors for cardiovascular diseases, including age, obesity, hypertension, hyperlipidemia, and diabetes mellitus, are the same for MAC and atherosclerosis. The aim of this study was to assess the neutrophil–lymphocyte ratio (NLR), an inflammatory marker, in patients with MAC. The study group consisted of 117 patients with MAC. Age and sex-matched control group was composed of 38 patients who were admitted to echocardiography laboratory due to su...
Source: Blood Coagulation and Fibrinolysis - August 5, 2014 Category: Hematology Tags: Original Articles Source Type: research

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