The relation between acute intracerebral hemorrhage and diffusion-weighted imaging lesions: a meta-analysis

AbstractDiffusion-weighted imaging lesions in intracerebral hemorrhage are related to a higher risk of recurrent intracerebral hemorrhage, cognitive damage, and mortality. However, it has been reported that the relationship between the risk of diffusion-weighted imaging lesions and intracerebral hemorrhage subtype or the possible risk factors for diffusion-weighted imaging lesions is variable. This meta-analysis was performed to evaluate this relationship. A systematic literature search up-to August 2020 was performed and 12 studies included 2815 subjects at the baseline with intracerebral hemorrhage. Odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs) was calculated to evaluate the prognostic role of diffusion-weighted imaging lesions and intracerebral hemorrhage subtype and investigated the possible risk factors for diffusion-weighted imaging lesions using the dichotomous and continuous methods with a random or fixed-effect model. Lobar intracerebral hemorrhage was not significantly related to a higher rate of diffusion-weighted imaging lesions (OR, 1.01; 95% CI, 0.75 –1.36, p = 0.94) compared to the non-lobar intracerebral hemorrhage. Also, history of diabetes mellitus (OR, 1.15; 95% CI, 0.83–1.60, p = 0.39); history of smoking (OR, 0.95; 95% CI, 0.68–1.33, p = 0.76); history of hypercholesterolemia (OR, 1.04; 95% CI, 0.73–1.48, p = 0.83) ; and history of ischemic stroke (OR, 1.63; 95% CI, 0.57–4.66, p = 0.36) were not ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research