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D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale.
Abstract Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke, given the possibility of paradoxical embolism from venous to systemic circulation. D-dimer level is used to screen venous thrombosis. We investigated the risk of embolism and mortality according to the presence of PFO and D-dimer levels in cryptogenic stroke patients. A total of 570 first-ever cryptogenic stroke patients who underwent transesophageal echocardiography were included in this study. D-dimer was assessed using latex agglutination assay during admission. The association of long-term outcomes with the presence of PFO and D-di...
Source: Thrombosis and Haemostasis - May 21, 2015 Category: Hematology Authors: Kim YD, Song D, Nam HS, Lee K, Yoo J, Hong GR, Lee HS, Nam CM, Heo JH Tags: Thromb Haemost Source Type: research

Clinical and laboratory predictors of deep vein thrombosis after acute stroke; does D-dimer really improve predictive power?
We have read with great interest the paper “Clinical and laboratory predictors of deep vein thrombosis after acute stroke” by Balogun et al. [1], in which the authors investigate the interesting and relevant topic of deep vein thrombosis (DVT) prediction after acute stroke. Specifically, their main research question focusses on the predictive value of stroke severity score and markers of haemostatic activation. This is a relevant question as venous thrombosis, mainly manifested as DVT and pulmonary embolism, is regarded as a serious, potentially life-threatening complication in stroke patients, even though the reports ...
Source: Thrombosis Research - July 3, 2016 Category: Hematology Authors: Vasilis Kola, Hugoline de Haan, Bob Siegerink Tags: Correspondence Source Type: research

Pulmonary embolism and fatal stroke in a patient with severe factor XI deficiency after bariatric surgery
We report the case of a 40-year-old woman with a severe factor XI (FXI) deficiency who died from a stroke due to bilateral internal carotid arteries occlusion after a laparoscopic gastric bypass (bariatric surgery). This stroke was probably secondary to a pulmonary embolism with a paradoxical embolism through a previously unknown foramen ovale. This woman who had one severe episode of bleeding before the bypass received for the intervention a single infusion of 27 U/kg of FXI concentrate. A careful evaluation of the bleeding and thrombotic risk was performed before surgery, and despite all preventive measures, this tragi...
Source: Blood Coagulation and Fibrinolysis - April 1, 2013 Category: Hematology Tags: Case Reports Source Type: research

Patent foramen ovale increases the risk of acute ischemic stroke in patients with acute pulmonary embolism leading to right ventricular dysfunction
Patent foramen ovale (PFO) is an established risk factor for ischemic stroke. Since acute right ventricular dysfunction (RVD) observed in patients with PE can lead to right-to-left inter-atrial shunt via PFO, we hypothesized that PFO is a risk factor for ischemic stroke in PE with significant right ventricular dysfunction.
Source: Thrombosis Research - September 18, 2014 Category: Hematology Authors: Sylwia Goliszek, Małgorzata Wiśniewska, Katarzyna Kurnicka, Barbara Lichodziejewska, Michał Ciurzyński, Maciej Kostrubiec, Marek Gołębiowski, Marek Babiuch, Marzanna Paczynska, Marcin Koć, Piotr Palczewski, Anna Wyzgał, Piotr Pruszczyk Tags: Regular Article Source Type: research

Right ventricular stroke distance predicts death and clinical deterioration in patents with pulmonary embolism
The right ventricular outflow tract (RVOT) velocity time integral (VTI), an echocardiographic measure of stroke distance, correlates with cardiac index. We sought to determine the prognostic significance of low RVOT VTI on clinical outcomes among patients with acute pulmonary embolism (PE).
Source: Thrombosis Research - July 1, 2020 Category: Hematology Authors: Eugene Yuriditsky, Oscar J.L. Mitchell, Akhilesh K. Sista, Yuhe Xia, Rachel A. Sibley, Judy Zhong, William H. Moore, Nancy E. Amoroso, Ronald M. Goldenberg, Deane E. Smith, Shari B. Brosnahan, Catherine Jamin, Thomas S. Maldonado, James M. Horowitz Tags: Full Length Article Source Type: research

Right ventricular stroke distance predicts death and clinical deterioration in patients with pulmonary embolism
The right ventricular outflow tract (RVOT) velocity time integral (VTI), an echocardiographic measure of stroke distance, correlates with cardiac index. We sought to determine the prognostic significance of low RVOT VTI on clinical outcomes among patients with acute pulmonary embolism (PE).
Source: Thrombosis Research - July 2, 2020 Category: Hematology Authors: Eugene Yuriditsky, Oscar J.L. Mitchell, Akhilesh K. Sista, Yuhe Xia, Rachel A. Sibley, Judy Zhong, William H. Moore, Nancy E. Amoroso, Ronald M. Goldenberg, Deane E. Smith, Shari B. Brosnahan, Catherine Jamin, Thomas S. Maldonado, James M. Horowitz Tags: Full Length Article Source Type: research

The Lectin Pathway in Thrombotic Conditions-A Systematic Review.
In conclusion, lectin pathway activation may negatively influence outcome after ischaemic stroke and possibly contribute to CVE risk. Further research is warranted to elucidate the role of the lectin pathway in other thrombotic conditions. PMID: 29864785 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 4, 2018 Category: Hematology Authors: Larsen JB, Hvas CL, Hvas AM Tags: Thromb Haemost Source Type: research

Incidence of Bleeding in Patients with Sickle Cell Disease: A Population Based Study
Conclusion:The findings from our study indicate that SCD patients have a high cumulative incidence of bleeding. While the increased incidence of intracranial, urological, and retinal bleeding has been previously described and are confirmed here, we present the novel finding that SCD patients also have a high incidence of GI bleeding, the majority of which are from an upper GI source. The association of hemorrhagic stroke with a history of ischemic stroke is also confirmed. The association of bleeding with VTE is likely due, at least in part, to anticoagulation. Further studies on the causes and risk factors for GI bleeding...
Source: Blood - November 21, 2018 Category: Hematology Authors: Hariharan, N., Brunson, A. M., Keegan, T. H. M., Wun, T. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Organ Damage and Clinical Complications in Sickle Cell Disease Source Type: research

Pneumonia, thrombosis and vascular disease.
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2014 Category: Hematology Authors: Francesco Violi, Roberto Cangemi, Camilla Calvieri Tags: Review Article Source Type: research

The role of soluble fibrin during anticoagulant therapy: a case report
We present the case of a 70-year-old male patient with persistent NVAF who developed pulmonary thromboembolism (PTE), deep vein thrombosis (DVT), and left atrial thrombus during anticoagulant therapy with warfarin. Intravenous recombinant tissue plasminogen activator was administered during his acute PTE. Heparin and apixaban were administered over 28 days; heparin was discontinued after the DVT resolved, while apixaban was administered to prevent ischemic stroke. Two days after heparin was discontinued, the patient experienced an ischemic stroke. Dabigatran was administered for secondary ischemic stroke prevention. Solub...
Source: Thrombosis Journal - July 6, 2015 Category: Hematology Authors: Tohru KawakamiNobukiyo TanakaHiroki IshiharaHiroyoshi Ohno Source Type: research

Real World Experience of Direct Oral Anticoagulants with Comparison of Safety Outcomes to the Warfarin Era of Venous Thromboembolism Treatment
Conclusion:This retrospective audit shows that our local safety outcomes are comparable to clinical trials. Low dose anticoagulation and high falls risk (a surrogate marker of frailty) were significant risk factors for both clinically significant bleeding and thrombotic stroke in the DOAC population. These patients are likely frailer with greater co-morbidities and have shared risk factors for bleeding and stroke, suggesting that for these high risk patients, low dose anticoagulation does not negate their risk of complications and careful prescribing and close monitoring remain essential.The sub-comparison between VTE pati...
Source: Blood - November 21, 2018 Category: Hematology Authors: Brook, R., Aswapanyawongse, N., Lim, H. Y., Ho, P. Tags: 331. Pathophysiology of Thrombosis: Poster II Source Type: research

Indications, Efficacy and Complications of Kcentra Use in Reversing Coagulopathy
ConclusionsKcentra was used in several off-label clinical settings, with comparable mortality among the coumadin, rivaroxaban and apixaban groups and no identifiable benefit in the setting of cirrhosis, DIC or antiplatelet medications, but with an increased incidence of deep vein thrombosis and stroke.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Sritharan, N., Triulzi, D. Tags: 401. Basic Science and Clinical Practice in Blood Transfusion: Poster III Source Type: research

Adverse Events and All-Cause Mortality in Danish Patients with Cerebral Venous Thrombosis: A Nationwide Cohort Study
CONCLUSION: Intracranial bleeding, ischemic stroke, and mortality risks were higher for patients with CVT than matched patients with VTE and the general population, particularly within 6 months after diagnosis.PMID:35688451 | DOI:10.1055/s-0042-1743473
Source: Thrombosis and Haemostasis - June 10, 2022 Category: Hematology Authors: Anne Gulbech Ording Flemming Skj øth S øren Due Andersen Torben Bjerregaard Larsen Source Type: research

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