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Platelets and COVID-19
Hamostaseologie. 2021 Oct;41(5):379-385. doi: 10.1055/a-1581-4355. Epub 2021 Oct 25.ABSTRACTIn 2019 first reports about a new human coronavirus emerged, which causes common cold symptoms as well as acute respiratory distress syndrome. The virus was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe thrombotic events including deep vein thrombosis, pulmonary embolism, and microthrombi emerged as additional symptoms. Heart failure, myocardial infarction, myocarditis, and stroke have also been observed. As main mediator of thrombus formation, platelets became one of the key aspects in SARS-C...
Source: Hamostaseologie - October 25, 2021 Category: Hematology Authors: Anne-Katrin Rohlfing Dominik Rath Tobias Geisler Meinrad Gawaz Source Type: research

Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy
Platelets. 2022 Feb 2:1-10. doi: 10.1080/09537104.2021.2023735. Online ahead of print.ABSTRACTInterrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or pulmonary embolism. The underlying key receptor distributions and interactions, in particular the relevance of integrin clustering, are not fully understood is because of highly abundant and densely distributed αIIbβ3 receptors. This makes receptor distributions difficult to assess ev...
Source: Platelets - February 3, 2022 Category: Hematology Authors: Hannah S Heil Max Aigner Sophia Maier Prateek Gupta Luise M C Evers Vanessa G öb Charly Kusch Mara Meub Bernhard Nieswandt David Stegner Katrin G Heinze Source Type: research

An Update on Safe Anticoagulation
Hamostaseologie. 2022 Feb;42(1):65-72. doi: 10.1055/a-1717-7958. Epub 2022 Feb 23.ABSTRACTBlood coagulation is essential to maintain the integrity of a closed circulatory system (hemostasis), but also contributes to thromboembolic occlusion of vessels (thrombosis). Thrombosis may cause deep vein thrombosis, pulmonary embolism, myocardial infarction, peripheral artery disease, and ischemic stroke, collectively the most common causes of death and disability in the developed world. Treatment for the prevention of thromboembolic diseases using anticoagulants such as heparin, coumarins, thrombin inhibitors, or antiplatelet drug...
Source: Hamostaseologie - February 23, 2022 Category: Hematology Authors: Reiner K Mailer Piotr Kuta Thomas Renn é Source Type: research

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