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Specialty: Geriatrics
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Total 1481 results found since Jan 2013.
The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats
Exp Gerontol. 2021 Feb 17;147:111286. doi: 10.1016/j.exger.2021.111286. Online ahead of print.ABSTRACTBrain-derived neurotrophic factor (BDNF) is known to have neuroprotective effects on multiple neurovascular diseases especially poststroke recovery. On the other hand, BDNF reported to increase blood pressure (BP) which is one of the major risk factors for stroke onset. To clarify the conflicting effects on stroke onset, we examined the expression of endogenous BDNF in relation to stroke onset. In addition, we explored the effect of exogenous central BDNF against stroke onset and all-cause mortality as the primary endpoint...
Source: Experimental Gerontology - February 20, 2021 Category: Geriatrics Authors: Yu Hasegawa Yushin Takemoto Kenyu Hayashi Koki Kameno Shokei Kim-Mitsuyama Source Type: research
The experience of uncertainty for patients, families and healthcare providers in post-stroke palliative and end-of-life care: a qualitative meta-synthesis
Conclusionsto mitigate the degree of uncertainty post-stroke, HCPs should be present, provide clear direct communication and incorporate the value-based goals of care within their medical treatment plan. These findings suggest that future research is needed to focus on how PC approaches can be integrated into stroke care programmes.
Source: Age and Ageing - November 18, 2020 Category: Geriatrics Source Type: research
The endogenous and exogenous brain-derived neurotrophic factor plays pivotal roles in the pathogenesis of stroke onset in high salt-loaded hypertensive rats
Exp Gerontol. 2021 Feb 17;147:111286. doi: 10.1016/j.exger.2021.111286. Online ahead of print.ABSTRACTBrain-derived neurotrophic factor (BDNF) is known to have neuroprotective effects on multiple neurovascular diseases especially poststroke recovery. On the other hand, BDNF reported to increase blood pressure (BP) which is one of the major risk factors for stroke onset. To clarify the conflicting effects on stroke onset, we examined the expression of endogenous BDNF in relation to stroke onset. In addition, we explored the effect of exogenous central BDNF against stroke onset and all-cause mortality as the primary endpoint...
Source: Experimental Gerontology - February 20, 2021 Category: Geriatrics Authors: Yu Hasegawa Yushin Takemoto Kenyu Hayashi Koki Kameno Shokei Kim-Mitsuyama Source Type: research
Current characteristics and early functional outcome of older stroke patients: a population-based study (Dijon Stroke Registry)
Conclusionthe increasing burden of stroke in older people has major implications for future treatment strategies and need for dedicated care facilities.
Source: Age and Ageing - October 3, 2020 Category: Geriatrics Source Type: research
505 interleukin-6, c-reactive protein, fibrinogen, and risk of recurrence after ischemic stroke: systematic review and meta-analysis
ConclusionDespite evidence suggesting an association between inflammatory markers and post-stroke vascular recurrence, substantial methodological heterogeneity was apparent between studies. Individual-patient pooled analysis and standardisation of methods are needed to determine the prognostic role of blood inflammatory markers and to improve patient selection for randomised trials of inflammatory therapies.
Source: Age and Ageing - June 12, 2021 Category: Geriatrics Source Type: research
Prediction of post-stroke cognitive impairment by Montreal Cognitive Assessment (MoCA) performances in acute stroke: comparison of three normative datasets
CONCLUSIONS: The classification of acute stroke patients as normal/impaired based on MoCA thresholds proposed by general population normative datasets underestimated patients at risk of persistent PSCI. We calculated a new adjusted MoCA score predictive of PSCI in acute stroke patients to be further tested in larger studies.PMID:35441928 | DOI:10.1007/s40520-022-02133-9
Source: Aging Clinical and Experimental Research - April 20, 2022 Category: Geriatrics Authors: Emilia Salvadori Ilaria Cova Francesco Mele Simone Pomati Leonardo Pantoni Source Type: research
Stroke severity and outcomes for octogenarians receiving statins
Abstract: Pre-exposure to 3-hydroxy-3-methylgutaryl-coenzyne A reductase inhibitors (statins) appears to improve outcomes in patients with acute ischemic stroke (AIS). Whether this extends to patients over 80 is not known. Patients ≥80 years of age with AIS were retrospectively reviewed from the stroke registry of a tertiary stroke center. Pre-admission statin use, demographics, vascular risk factors, and comorbid conditions were assessed. Primary outcomes were admission National Institutes of Health Stroke Scale (NIHSS) scores and in-hospital mortality/discharge to hospice, and secondary outcomes included subsequent int...
Source: Archives of Gerontology and Geriatrics - July 1, 2013 Category: Geriatrics Authors: Michael S. Phipps, Neer Zeevi, Ilene Staff, Gil Fortunato, George A. Kuchel, Louise D. McCullough Source Type: research
Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study
Conclusion: Elevated stroke risk at midlife is associated with accelerated cognitive decline over 10 years. Aggregation of risk factors may be especially important in this association.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - November 30, 2012 Category: Geriatrics Authors: Sara Kaffashian, Aline Dugravot, Eric J. Brunner, Séverine Sabia, Joël Ankri, Mika Kivimäki, Archana Singh-Manoux Tags: Featured Articles Source Type: research
Stroke severity and outcomes for octogenarians receiving statins
Abstract: Pre-exposure to 3-hydroxy-3-methylgutaryl-coenzyne A reductase inhibitors (statins) appears to improve outcomes in patients with acute ischemic stroke (AIS). Whether this extends to patients over 80 is not known. Patients ≥80 years of age with AIS were retrospectively reviewed from the stroke registry of a tertiary stroke center. Pre-admission statin use, demographics, vascular risk factors, and comorbid conditions were assessed. Primary outcomes were admission National Institutes of Health Stroke Scale (NIHSS) scores and in-hospital mortality/discharge to hospice, and secondary outcomes included subsequent int...
Source: Archives of Gerontology and Geriatrics - July 1, 2013 Category: Geriatrics Authors: Michael S. Phipps, Neer Zeevi, Ilene Staff, Gil Fortunato, George A. Kuchel, Louise D. McCullough Source Type: research
Evaluation of driving confidence in post‐stroke older drivers in South Australia
ConclusionStroke survivors who return to driving have no differences in their driving confidence to their aged‐matched non‐stroke driving peers. Timely recognition of lack of driving confidence might allow for appropriately targeted intervention strategies and prevent premature driving cessation.
Source: Australasian Journal on Ageing: - December 26, 2013 Category: Geriatrics Authors: Annabel McNamara, Julie Ratcliffe, Stacey George Tags: Brief Report Source Type: research
The effects of increased therapy time on cognition and mood in frail patients with a stroke who rehabilitate on rehabilitation units of nursing homes in the Netherlands: a protocol of a comparative study
DiscussionThe present study evaluates the effect of increased therapy time on cognition, mood (level of depression and anxiety), and ADL in stroke patients. When positive effects will be found this study can guide policy makers and practitioners on how to implement more therapy time on rehabilitation wards of nursing homes.Trial registration: TNR Our study has been documented in the Dutch Trial Registration, TC = 3871.
Source: BMC Geriatrics - May 23, 2014 Category: Geriatrics Authors: Marleen Huijben-SchoenmakersArno RademakerPeter RoodenErik Scherder Source Type: research
Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study
Conclusion Elevated stroke risk at midlife is associated with accelerated cognitive decline over 10 years. Aggregation of risk factors may be especially important in this association.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - October 24, 2014 Category: Geriatrics Source Type: research
