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Specialty: Materials Science

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Total 154 results found since Jan 2013.

Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach
CONCLUSION: The developed iFEM approach combined with the inverted GP model successfully predicted component-wise material properties of intact atherosclerotic human carotids ex-vivo under physiological-like loading conditions.SIGNIFICANCE: We developed a novel iFEM framework for the nonlinear, component-wise material characterization of atherosclerotic arteries and utilized it to obtain human atherosclerotic carotid material properties. The developed iFEM framework has great potential to be advanced for patient-specific in-vivo application.PMID:34864574 | DOI:10.1016/j.jmbbm.2021.104996
Source: Journal of the Mechanical Behavior of Biomedical Materials - December 5, 2021 Category: Materials Science Authors: Su Guvenir Torun Hakki M Torun Hendrik H G Hansen Chris L de Korte Antonius F W van der Steen Frank J H Gijsen Ali C Akyildiz Source Type: research

Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, and NINDS (National Institute of Neurological Disorders and Stroke) Early Phase Pain Investigation Clinical Network (EPPIC-Net) Provides Robust Infrastructure for Clinical Trials of Non-addictive Pain Therapeutics
We present EPPIC-Net's accomplishments since opening in Q4 of 2019. In its first year, EPPIC-Net established a robust infrastructure including a Clinical Coordinating Center, Data Coordinating Center, and 12 Specialized Clinical Centers across th e US, providing broad outreach to diverse pain populations.
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Barbara Karp, Rebecca Hommer, Marlene Peters Lawrence, Jennifer H. Barnes, Clinton B. Wright Tags: Clinical Trials for Pain Research121 Source Type: research

NIH HEAL Initiative: National Institute of Neurological Disorders and Stroke Preclinical Program for Non-Addictive Pain Therapeutic Development
The National Institutes of Health Helping to End Addiction Long-term, or NIH HEAL Initiative aims to focus efforts on advancing scientific solutions to stem the opioid crisis, improving prevention and treatment of opioid misuse/addiction, and enhancing pain management. NINDS is charged with accelerating the discovery and development of new non-addictive pharmacologic and non-pharmacologic pain therapeutics as part of the HEAL Initiative. PSPP provides researchers from academia and industry, within the US and internationally, an efficient, rigorous, one-stop in vivo resource to screen and profile therapeutic candidates incl...
Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Sarah Woller, Smriti Iyengar Tags: 107 Source Type: research

ASAP Neutrophil-Biomimetic “Nanobuffer” for Remodeling the Microenvironment in the Infarct Core and Protecting Neurons in the Penumbra via Neutralization of Detrimental Factors to Treat Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c09020
Source: ACS Applied Materials and Interfaces - June 13, 2022 Category: Materials Science Authors: Shanshan Liu, Jianpei Xu, Yipu Liu, Yang You, Laozhi Xie, Shiqiang Tong, Yu Chen, Kaifan Liang, Songlei Zhou, Fengan Li, Zhuang Tang, Ni Mei, Huiping Lu, Xiaolin Wang, Xiaoling Gao, and Jun Chen Source Type: research

ASAP Effect of Tetrahedral Framework Nucleic Acids on Neurological Recovery via Ameliorating Apoptosis and Regulating the Activation and Polarization of Astrocytes in Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c10364
Source: ACS Applied Materials and Interfaces - August 11, 2022 Category: Materials Science Authors: Mi Zhou, Tianxu Zhang, Xiaolin Zhang, Mei Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Jun Li, and Yunfeng Lin Source Type: research

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research

ASAP Correction to “A Co-Doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke ”
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c12150
Source: ACS Applied Materials and Interfaces - September 19, 2022 Category: Materials Science Authors: Yunsheng Liu, Xiaojun Wang, Xiangzhu Li, Shanshan Qiao, Guodong Huang, Dirk Matthias Hermann, Thorsten Roland Doeppner, Muling Zeng, Wei Liu, Gelin Xu, Lijie Ren, Yuan Zhang, Wenlan Liu, Eudald Casals, Weiping Li, and Ya-Chao Wang Source Type: research

Sensors ‐based monitoring and treatment approaches for in‐stent restenosis
AbstractCardiovascular disease (CVD) can progressively narrow arteries due to plaque accumulation on the inner walls of the blood vessels, which results in an obstructed blood flow, leading to heart attack, stroke, and even death if the obstruction is severe. A popular treatment for the disease is to use an intravascular mechanical device called the stent to achieve an immediate restoration of blood flow. However, the physical stimulation induced by the stent expansion can cause inflammation of the vessel tissue. As one of the most common post-stenting complications, re-narrowing of the vessel is the main pathology that le...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - September 26, 2022 Category: Materials Science Authors: Ying Yi, Bo Wang, Changping Li Tags: REVIEW ARTICLE Source Type: research

Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane
Biomaterials. 2022 Dec 23;293:121983. doi: 10.1016/j.biomaterials.2022.121983. Online ahead of print.ABSTRACTThe basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highl...
Source: Biomaterials - January 7, 2023 Category: Materials Science Authors: Jeong-Won Choi Jaeseung Youn Dong Sung Kim Tae-Eun Park Source Type: research

The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research

A new insight into the mechanical properties of nanobiofibers and vibrational behavior of atomic force microscope beam considering them as the samples
J Mech Behav Biomed Mater. 2023 Apr 5;142:105842. doi: 10.1016/j.jmbbm.2023.105842. Online ahead of print.ABSTRACTNowadays, the utilization and production of polymeric nanofibers are expanding rapidly due to their unique and exclusive properties. The current study examined silk fibroin nanofibers, poly-L lactic acid (PLLA), and polycaprolactone (PCL) as three widely-used biopolymers. In the first section, the mechanical properties of nanobiofibers, including elastic modulus as the first research variable, were investigated using atomic force microscopy (AFM)-based nanoindentation and tensile testing (through a universal te...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 9, 2023 Category: Materials Science Authors: Ali Jafari Ali Sadeghi Source Type: research

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