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Total 154 results found since Jan 2013.

Patient-specific biomechanical analysis of atherosclerotic plaques enabled by histologically validated tissue characterization from computed tomography angiography: A case study
CONCLUSION: Patient specific tissue characterization can identify distributions of stress and strain in a clinically relevant range. This capability may be used to identify high-risk lesions and personalize treatment decisions for individual patients with cardiovascular disease and improve prevention of myocardial infarction and stroke.PMID:36049368 | DOI:10.1016/j.jmbbm.2022.105403
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 1, 2022 Category: Materials Science Authors: Andrew J Buckler Max van Wanrooij M åns Andersson Eva Karl öf Ljubica Perisic Matic Ulf Hedin T Christian Gasser Source Type: research

Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research

A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure
CONCLUSIONS: The surrogate model provides nearly instantaneous estimates and constitutes a valuable tool for evaluating the risk of thrombus rupture during pre-operative planning for the treatment of acute ischemic stroke.PMID:36410165 | DOI:10.1016/j.jmbbm.2022.105577
Source: Journal of the Mechanical Behavior of Biomedical Materials - November 21, 2022 Category: Materials Science Authors: Sara Bridio Giulia Luraghi Francesco Migliavacca Sanjay Pant Alberto Garc ía-González Jose F Rodriguez Matas Source Type: research

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.
Abstract Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Riegler J, Liew A, Hynes SO, Ortega D, O'Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF Tags: Biomaterials Source Type: research

Targeted delivery of Neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury.
In conclusion, the targeted delivery of TAT-LBD-Ngn2 into the ischemic zone attenuated cerebral ischemia-reperfusion injury through the inhibition of neuronal degeneration and apoptosis, suggesting that TAT-LBD-Ngn2 is a promising target candidate for the treatment of ischemic stroke. PMID: 23942209 [PubMed - as supplied by publisher]
Source: Biomaterials - August 10, 2013 Category: Materials Science Authors: Deng B, Gou X, Chen H, Li L, Zhong H, Xu H, Jiang F, Zhao Z, Wang Q, Xu L Tags: Biomaterials Source Type: research

Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles.
Abstract The translation of experimental stroke research from the laboratory to successful clinical practice remains a formidable challenge. We previously reported that PEGylated-lipid nanoparticles (PLNs) effectively transport across the blood-brain barrier along with less inflammatory responses. In the present study, PLNs conjugated to Fas ligand antibody that selectively present on brain ischaemic region were used for therapeutic targeting. Fluorescent analysis of the mice brain show that encapsulated 3-n-Butylphthalide (dl-NBP) in PLNs conjugated with Fas ligand antibody effectively delivered to ipsilateral re...
Source: Biomaterials - October 10, 2013 Category: Materials Science Authors: Lu YM, Huang JY, Wang H, Lou XF, Liao MH, Hong LJ, Tao RR, Ahmed MM, Shan CL, Wang XL, Fukunaga K, Du YZ, Han F Tags: Biomaterials Source Type: research

Genetically encoded FRET-based biosensor for imaging MMP-9 activity.
Abstract A genetically encoded Förster Resonance Energy Transfer (FRET)-based biosensor that continuously monitors matrix metalloproteinase 9 (MMP-9) activity was developed. MMP-9 is an extracellularly acting endopeptidase with a prominent role in development, learning and memory, cancer metastasis, and stroke. To assess the biological function of the protease, determining the precise kinetics and localization of MMP-9 activity is required. The nontoxic, genetically encoded FRET biosensor presented herein is anchored in the cellular membrane and thus provides an important advantage over currently employed probes....
Source: Biomaterials - November 26, 2013 Category: Materials Science Authors: Stawarski M, Rutkowska-Wlodarczyk I, Zeug A, Bijata M, Madej H, Kaczmarek L, Wlodarczyk J Tags: Biomaterials Source Type: research

Materials considerations of implantable neuroengineering devices for clinical use
Publication date: Available online 16 September 2014 Source:Current Opinion in Solid State and Materials Science Author(s): Daniel R. Merrill Implantable devices for recording and stimulation of the human nervous system offer promise for the treatment of disorders including spinal cord injury, stroke, traumatic brain injury, sensory and motor deficits, chronic pain, epilepsy, Parkinson’s disease and amputation. While advances in neuroengineering devices have been impressive, often the expectations and desires for a chronically implantable device remain unrealized. In the face of engineering approaches which perform wel...
Source: Current Opinion in Solid State and Materials Science - November 1, 2014 Category: Materials Science Source Type: research

A study of direct forging process for powder superalloys
Publication date: Available online 24 October 2014 Source:Materials Science and Engineering: A Author(s): Q. Bai , J. Lin , J. Jiang , T.A. Dean , J. Zou , G. Tian Powder metallurgy (PM) processing of nickel-based superalloys has been used for a wide range of near net-shape fine grained products. In this paper a novel forming process, i.e. direct forging of unconsolidated powder superalloys is proposed. In this process, encapsulated and vacuumed powder particles are heated up to a forming temperature and forged directly at high speed to the final shape, by using a high forming load. Experiments of direct powder forging h...
Source: Materials Science and Engineering: A - November 4, 2014 Category: Materials Science Source Type: research

Effective cleaning process and its influence on surface roughness in anodic bonding for semiconductor device packaging
Publication date: March 2015 Source:Materials Science in Semiconductor Processing, Volume 31 Author(s): Robin Joyce , Kulwant Singh , Soney Varghese , Jamil Akhtar Wafer cleanliness and surface roughness play a paramount role in an anodic bonding process. Impurities and the roughness on the wafer surface result in unbonded areas which lead to fringes and Newton׳s rings. With an augment in surface roughness, lesser area will be in stroke thus making more pressure and voltage to be applied onto the wafers for better bonding. Eventually it became mandatory to choose the best cleaning process for the bonding technology that...
Source: Materials Science in Semiconductor Processing - December 4, 2014 Category: Materials Science Source Type: research

Stem cells and applications: A survey.
Abstract Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been increasing interest in the study of undifferentiated progenitors that have ability to proliferate and differentiate in different tissues. Different stem cells (SC) with different potential can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult stem cells provide a more interesting approach to clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue or MSC of Wharton Jelly, which have limited potential, are ...
Source: Bio-Medical Materials and Engineering - January 1, 2015 Category: Materials Science Authors: Stoltz JF, Bensoussan D, Zhang L, Decot V, De Isla N, Li YP, Huselstein C, Benkirane-Jessel N, Li N, Reppel L, He Y, Li YY Tags: Biomed Mater Eng Source Type: research

Tribological property investigation on a novel pneumatic actuator with integrated piezo actuators
This article investigates vibrations of the seal generated by integrated piezo actuators to reduce friction force. For this, two piezoelectric stacks are integrated in the cylinder and used to excite vibration modes. This concept was studied in a compact cylinder pneumatic actuator with a bore diameter of 5mm and a stroke of 10mm. Dry friction measurement shows a 52% reduction from the original friction force at a driving frequency of 18.29kHz and vibration amplitude of 0.05μm. In the wet friction experiments, the friction force can be reduced by 54% from the original wet friction with vibrations at amplitude of 0.04μm.
Source: Tribology International - February 20, 2015 Category: Materials Science Source Type: research

Critical buckling pressure in mouse carotid arteries with altered elastic fibers.
This study provides experimental and theoretical methods for further investigating the influence of genetic mutations in elastic fibers on buckling behavior and the development of arterial tortuosity. PMID: 25771258 [PubMed - as supplied by publisher]
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 28, 2015 Category: Materials Science Authors: Luetkemeyer CM, James RH, Devarakonda ST, Le VP, Liu Q, Han HC, Wagenseil JE Tags: J Mech Behav Biomed Mater Source Type: research