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Total 154 results found since Jan 2013.
Non-invasive monitoring of transplanted endothelial progenitor cells in diabetic ischemic stroke models.
The objectives of this study were to establish a non-invasive imaging strategy to monitor the homing of transplanted EPCs in diabetic stroke mice and to assess the effect of RWJ 67657, an inhibitor of p38 MAPK, on the homing ability of exogenous EPCs. Bone marrow-derived EPCs were labeled in vitro with a multi-functional nanoprobe modified with paramagnetic chelators and fluorophores before being infused into stroke mice. The signal of the nanoprobe reached its peak on day 5 in both magnetic resonance imaging and near-infrared fluorescence imaging after EPC transplantation in wild-type stroke models. The signal enhancemen...
Source: Biomaterials - November 26, 2014 Category: Materials Science Authors: Bai YY, Wang L, Peng XG, Wang YC, Chang D, Zheng S, Ding J, Li C, Ju S Tags: Biomaterials Source Type: research
Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
Biomaterials. 2021 Aug 31;277:121111. doi: 10.1016/j.biomaterials.2021.121111. Online ahead of print.ABSTRACTIschemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic st...
Source: Biomaterials - September 6, 2021 Category: Materials Science Authors: Wenxiu He Zhiwen Zhang Xianyi Sha Source Type: research
Engineered stem cell mimics to enhance stroke recovery.
Abstract
Currently, no medical therapies exist to augment stroke recovery. Stem cells are an intriguing treatment option being evaluated, but cell-based therapies have several challenges including developing a stable cell product with long term reproducibility. Since much of the improvement observed from cellular therapeutics is believed to result from trophic factors the stem cells release over time, biomaterials are well-positioned to deliver these important molecules in a similar fashion. Here we show that essential trophic factors secreted from stem cells can be effectively released from a multi-component hydr...
Source: Biomaterials - June 13, 2018 Category: Materials Science Authors: George PM, Oh B, Dewi R, Hua T, Cai L, Levinson A, Liang X, Krajina BA, Bliss TM, Heilshorn SC, Steinberg GK Tags: Biomaterials Source Type: research
Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke
AbstractEndogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 11, 2018 Category: Materials Science Authors: Leyre Sanchez ‐Rojas,
Ulises Gómez‐Pinedo,
María Soledad Benito‐Martin,
Gonzalo León‐Espinosa,
Fernando Rascón‐Ramirez,
Cristina Lendinez,
Cristina Martínez‐Ramos,
Jorge Matías‐Guiu,
Manuel Monleón Pradas,
Juan A. Barcia Tags: Original Research Report Source Type: research
A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain.
Abstract
Neural stem cell implantations have been extensively investigated for treatment of brain diseases such as stroke. In order to follow the localization and functional status of cells after implantation noninvasive imaging is essential. Therefore, we developed a comprehensive multi-modality platform for in vivo imaging of graft localization, density, and survival using 19F magnetic resonance imaging in combination with bioluminescence imaging. We quantitatively analyzed cell graft survival over the first 4 weeks after transplantation in both healthy and stroke-damaged mouse brain and correlated our findings...
Source: Biomaterials - December 16, 2013 Category: Materials Science Authors: Boehm-Sturm P, Aswendt M, Minassian A, Michalk S, Mengler L, Adamczak J, Mezzanotte L, Löwik C, Hoehn M Tags: Biomaterials Source Type: research
Reliability of the portable gait rhythmogram in post-stroke patients.
CONCLUSIONS: Based on this excellent reliability of the PGR in post-stroke patients, it can be recommended as a simple test of gait analysis in this population.
PMID: 33164920 [PubMed - as supplied by publisher]
Source: Bio-Medical Materials and Engineering - November 2, 2020 Category: Materials Science Authors: Miyata R, Matsumoto S, Miura S, Kawamura K, Uema T, Miyara K, Niibo A, Hoei T, Ogura T, Shimodozono M Tags: Biomed Mater Eng Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke.
Abstract
CT angiography (CTA) and CT perfusion (CTP) imaging can play important roles in the workup of acute ischemic stroke. However, these techniques are hindered by the large amounts of contrast agents (CAs) required, high doses of X-ray radiation exposure, and nephrotoxicity of the clinical used iodinated CAs. To address these problems, we synthesized and validated a novel class of CT CAs, PEGylated BaHoF5 nanoparticles (NPs), for CTA and CTP imaging, which can greatly enhance the diagnostic sensitivity and accuracy of ischemic stroke. These agents have unique advantages over conventional iodinated CT agents, ...
Source: Biomaterials - August 20, 2015 Category: Materials Science Authors: Wang J, Ni D, Bu W, Zhou Q, Fan W, Wu Y, Liu Y, Yin L, Cui Z, Zhang X, Zhang H, Yao Z Tags: Biomaterials Source Type: research
Magnetic resonance imaging detection of multiple ischemic injury produced in an adult rat model of minor stroke followed by mild transient cerebral ischemia
ConclusionWithin regions adjacent to an experimental minor stroke, a recurrence of a mild transient cerebral ischemia augmented T2 above increases produced by tMCAO alone, reflecting increased damage in this region. Exacerbation appeared broader with acute versus chronic recovery between insults.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - November 3, 2016 Category: Materials Science Source Type: research
A comparative study of the sensitivity of diffusion-related parameters obtained from diffusion tensor imaging, diffusional kurtosis imaging, q-space analysis and bi-exponential modelling in the early disease course (24 h) of hyperacute (6 h) ischemic stroke patients
ConclusionOur comparison was performed using identical diffusion encoding timings and on patients in the same stage of their condition. Although preliminary, our findings confirm those of previous studies that showed enhanced sensitivity of kurtosis. A fine time mapping of diffusion metrics in hyperacute stroke patients was presented which advocates for further investigations on larger animal or human cohorts.
Source: Magnetic Resonance Materials in Physics, Biology and Medicine - March 5, 2017 Category: Materials Science Source Type: research
The potential of iRest in measuring the hand function performance of stroke patients.
CONCLUSION: There is a potential of using iRest, a non-motorized device in predicting MAS score.
PMID: 28372264 [PubMed - in process]
Source: Bio-Medical Materials and Engineering - April 6, 2017 Category: Materials Science Authors: Abdul Rahman H, Khor KX, Yeong CF, Su EL, Narayanan AL Tags: Biomed Mater Eng Source Type: research
Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain.
Abstract
Ischemic stroke results in a loss of neurons for which there are no available clinical strategies to stimulate regeneration. While preclinical studies have demonstrated that functional recovery can be obtained by transplanting an exogenous source of neural progenitors into the brain, it remains unknown at which stage of neuronal maturity cells will provide the most benefit. We investigated the role of neuronal maturity on cell survival, differentiation, and long-term sensorimotor recovery in stroke-injured rats using a population of human cortically-specified neuroepithelial progenitor cells (cNEPs) deliv...
Source: Biomaterials - November 15, 2018 Category: Materials Science Authors: Payne SL, Tuladhar A, Obermeyer JM, Varga BV, Teal CJ, Morshead CM, Nagy A, Shoichet MS Tags: Biomaterials Source Type: research
P2X4R contributes to central disinhibition via TNF- α/TNFR1/GABAaR pathway in post-stroke pain rats
Stroke is the leading cause of adult disability worldwide41. Central post-stroke pain (CPSP) is a chronic neuropathic pain, which is one of the most difficult sequelae of ischemic and hemorrhagic stroke11. This syndrome is characterized by spontaneous or an abnormal sensation secondary to noxious or non-noxious stimuli including spontaneous pain, hyperalgesia, and allodynia17, which localize at one of multiple sites in the somatosensory pathway27. Thalamus stroke is one of the major causes of neuropathic central pain.
Source: The Journal of Pain - March 4, 2021 Category: Materials Science Authors: Jiajie Lu, Xiaoning Guo, Manyun Yan, Xiaqing Yuan, Shujun Chen, Yiqing Wang, Juehua Zhu, Shicun Huang, Haitao Shen, Haiying Li, Qun Xue, Qi Fang, Jianqiang Ni, Lei Gan, Hongru Zhao, Haifeng Lu, Gang Chen Tags: Original Reports Source Type: research
The potential role of the novel orodispersible film from rice polymer loaded with silkworm pupae hydrolysate and the combined extract of holy basil and ginger for the management of stroke with stress
In this study, we explored the neuroprotective effect of an orodispersible film derived from a rice polymer loaded with silkworm pupae and the combined extract of holy basil and ginger (JP1). Male Wistar rats weighing 200-250 g were administered JP1 at the doses of 1, 10, and 100 mg/kg BW 45 min prior to an exposure to a 6-h immobilization stress for 14 days. Permanent, occlusion of the right middle cerebral artery (MCAO) was performed, and JP1 was administered continually for 21 days after MCAO. Assessments of the brain infarction volume, oxidative stress, inflammation, and apoptosis in the cerebral cortex were carried ou...
Source: Biomaterials - June 1, 2023 Category: Materials Science Authors: Putthiwat Thongwong Jintanaporn Wattanathorn Wipawee Thukhammee Somsak Tiamkao Source Type: research
