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Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography
AbstractA rodent model of embolic middle cerebral artery occlusion is used to mimic cerebral embolism in clinical patients. Thrombolytic therapy is the effective treatment for this ischemic injury. However, it is difficult to detect thrombolysis dynamically in living animals. Synchrotron radiation angiography may provide a novel approach to directly monitor the thrombolytic process and assess collateral circulation after embolic stroke. Thirty-six adult Sprague-Dawley rats underwent the embolic stroke model procedure and were then treated with tissue plasminogen activator. The angiographic images were obtained in vivo by s...
Source: Translational Stroke Research - January 24, 2019 Category: Neurology Source Type: research

Radiological Eye Deviation as a Predictor of Large Vessel Occlusion in Acute Ischaemic Stroke
This study sought to determine if radiological eye deviation was associated with LVO. Methods: All AIS patients given intravenous thrombolysis who had acute CTA performed in 2 stroke units were reviewed over 2013-2015 for the presence of LVO.
Source: Journal of Stroke and Cerebrovascular Diseases - June 10, 2019 Category: Neurology Authors: Gavin McCluskey, Annemarie Hunter, Elizabeth Best, Jacqueline McKee, Mark O. McCarron, Ferghal McVerry Source Type: research

The Yield of Multimodal Computed Tomography among Emergency Department Patients with Suspected Large Vessel Occlusion Stroke
Objectives: Endovascular therapy (EVT) improves outcomes for appropriately selected acute ischemic stroke patients. Guidelines suggest rapid acquisition of noninvasive vascular imaging to screen suspected ischemic stroke patients for large vessel occlusion (LVO) and candidacy for EVT. We sought to quantify the yield of an LVO stroke screening process in an undifferentiated emergency department (ED) suspected stroke population as well as identify predictors of successful EVT. Methods: We identified a cohort of consecutive ED patients who received CT angiography and brain perfusion (CTA/P) imaging to determine candidacy for EVT during 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2019 Category: Neurology Authors: Yalda Serena Dastmalchi, J. Adam Oostema Source Type: research

P041/42 Imaging study in stroke diagnosis and treatment in a referral center in Chile
ConclusionAs a conclusion, different topics of obtaining and observing images in Stroke are obtained. Either CT, MRA, Cerebral Angiography. Both nurses and technicians should know some generalities and topics of nomenclature, neuroanatomy, general and specific characteristics of each of the imaging techniques that we want to share for this ETMINT 2023 seminar.Disclosure of InterestNothing to disclose
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Nunez, F. B. Tags: 4. Ischemic stroke Source Type: research

Interobserver Agreement of ASPECT Score Distribution for Noncontrast CT, CT Angiography, and CT Perfusion in Acute Stroke Brief Reports
Conclusions— CTP-CBV demonstrates the highest interobserver agreement for individual ASPECTS regions.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Finlayson, O., John, V., Yeung, R., Dowlatshahi, D., Howard, P., Zhang, L., Swartz, R., Aviv, R. I. Tags: Acute Cerebral Infarction, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Diversity of Stroke Presentation in CADASIL: Study from Patients Harboring the Predominant NOTCH3 Mutation R544C
This study investigated the clinical stroke presentation and cranial magnetic resonance imaging (MRI) findings in a group of patients with CADASIL. We reviewed the clinical stroke presentation and brain MRI findings in 73 consecutive Korean patients aged>18 years diagnosed with CADASIL between May 2004 and April 2009. Brain MRI images were also scored for lacunar infarction and cerebral microbleeds. Intracranial atherosclerosis (ICAS) was assessed by magnetic resonance angiography. Disability was measured with the modified Rankin scale (mRS) and classified as good (mRS score 0-2) or poor (mRS score 3-5). In this study, 65 ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2011 Category: Neurology Authors: Jay Chol Choi, Sook-Keun Song, Jung Seok Lee, Sa-Yoon Kang, Ji-Hoon Kang Tags: Original Articles Source Type: research

Determinants of Neurologic Deterioration and Stroke-Free Survival After Spontaneous Cervicocranial Dissections: A Multicenter Study
Patients with spontaneous cervicocranial dissection (SCCD) may experience new or recurrent ischemic events despite antiplatelet or anticoagulant therapy. Treatment with stent placement is an available option; however, the literature on patient selection is limited. Thus, identifying patients at high risk for neurologic deterioration after SCCD is of critical importance. The present study examined the rate of neurologic deterioration in medically treated patients with SCCD and evaluated demographic, clinical, and radiologic factors affecting this deterioration. We retrospectively identified consecutive patients with SCCD ov...
Source: Journal of Stroke and Cerebrovascular Diseases - November 15, 2011 Category: Neurology Authors: Ameer E. Hassan, Vikram Jadhav, Haralabos Zacharatos, Saqib A. Chaudhry, Gustavo J. Rodriguez, Yousef M. Mohammad, M. Fareed K. Suri, Nauman Tariq, Gabriela Vazquez, Ramachandra P. Tummala, Robert A. Taylor, Adnan I. Qureshi Tags: Original Articles Source Type: research

Aortic stiffness measurement improves the prediction of asymptomatic coronary artery disease in stroke/transient ischemic attack patients
ConclusionsIn stroke/transient ischemic attack patients, aortic pulse wave velocity improves the prediction of ≥50% asymptomatic coronary artery disease beyond classical risk factors.
Source: International Journal of Stroke - July 1, 2013 Category: Neurology Authors: David Calvet, Emmanuel Touzé, Stéphane Laurent, Olivier Varenne, Jean‐Louis Sablayrolles, Pierre Boutouyrie, Jean‐Louis Mas Tags: Research Source Type: research

Timing-Invariant Imaging of Collateral Vessels in Acute Ischemic Stroke Clinical Sciences
Conclusions— Collateral vessels may not always be visible on standard single time-frame CTA because of delayed contrast arrival. Future prognostic studies in acute stroke should consider delay-insensitive techniques, such as TI-CTA, instead of standard single time-frame imaging, such as standard CTA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Smit, E. J., Vonken, E.-j., van Seeters, T., Dankbaar, J. W., van der Schaaf, I. C., Kappelle, L. J., van Ginneken, B., Velthuis, B. K., Prokop, M. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Combination of Noninvasive Neurovascular Imaging Modalities in Stroke Patients: Patterns of Use and Impact on Need for Digital Subtraction Angiography
Conclusions: In our experience, a combination of CTA and MRA was frequently used in patients in whom the initial noninvasive imaging was determined insufficient. The combination of findings from CTA and MRA were considered adequate in a large portion of patients resulting in a lower requirement for DSA and higher treatment impact from DSA.
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2012 Category: Neurology Authors: Ameer E. Hassan, Nassir Rostambeigi, Saqib A. Chaudhry, Asif A. Khan, Haralabos Zacharatos, Rakesh Khatri, Guven Uzun, Adnan I. Qureshi Tags: Original Articles Source Type: research

Admission Insular Infarction >25% Is the Strongest Predictor of Large Mismatch Loss in Proximal Middle Cerebral Artery Stroke Clinical Sciences
Conclusions— Admission insular infarction >25% is the strongest predictor of large mismatch loss in this cohort of proximal middle cerebral artery occlusive stroke. This outcome marker may help to identify treatment-eligible patients who are in greatest need of rapid reperfusion therapy.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Kamalian, S., Kemmling, A., Borgie, R. C., Morais, L. T., Payabvash, S., Franceschi, A. M., Kamalian, S., Yoo, A. J., Furie, K. L., Lev, M. H. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Intra-arterial Thrombectomy versus Standard Intravenous Thrombolysis in Patients with Anterior Circulation Stroke Caused by Intracranial Arterial Occlusions: A Single-center Experience
Background: Severely impaired patients with persisting intracranial occlusion despite standard treatment with intravenous (IV) administration of recombinant tissue plasminogen activator (rtPA) or presenting beyond the therapeutic window for IV rtPA may be candidates for interventional neurothrombectomy (NT). The safety and efficacy of NT by the Penumbra System (PS) were compared with standard IV rtPA treatment in patients with severe acute ischemic stroke (AIS) caused by large intracranial vessel occlusion in the anterior circulation.Methods: Consecutive AIS patients underwent a predefined treatment algorithm based on arri...
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Fabrizio Sallustio, Giacomo Koch, Silvia Di Legge, Costanza Rossi, Barbara Rizzato, Simone Napolitano, Domenico Samà, Natale Arnò, Angela Giordano, Domenicantonio Tropepi, Giulia Misaggi, Marina Diomedi, Costantino Del Giudice, Alessio Spinelli, Sebasti Tags: Original Articles Source Type: research

Impact of Window Setting Optimization on Accuracy of Computed Tomography and Computed Tomography Angiography Source Image-based Alberta Stroke Program Early Computed Tomography Score
This study analyzed the effect of optimization of window settings on the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) performed on noncontrast CT (NCCT) and CT angiography source images (CTA-SI). ASPECTS was calculated on NCCT and CTA-SI with standard and optimized window width/center settings in a consecutive series of patients with acute ishcemic stroke. The difference between CT-based ASPECTS and ASPECTS performed on follow-up magnetic resonance imaging (MRI) were calculated to determine the disparity between initial estimates of the extent of ischemia on CT and follow-up lesion imaging b...
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2012 Category: Neurology Authors: Ethem Murat Arsava, Jukka T. Saarinen, Ali Unal, Erhan Akpinar, Kader K. Oguz, Mehmet Akif Topcuoglu Tags: Original Articles Source Type: research

Internal Cerebral Vein Asymmetry on Follow-up Brain Computed Tomography after Intravenous Thrombolysis in Acute Anterior Circulation Ischemic Stroke Is Associated with Poor Outcome
Background: Identifying early predictors of functional outcome after acute ischemic stroke (AIS) is important for planning rehabilitation strategies. Internal cerebral veins (ICV) drain deep parts of brain, run parallel to each other, and consistently seen on computed tomography angiography (CTA). Even minor asymmetry in their filling can be identified. We hypothesized that venous drainage would be impaired in patients with acute occlusion of internal carotid artery or middle cerebral artery. Because systemic thrombolysis can alter the vascular findings, we evaluated the relationship between ICV asymmetry on follow-up CTA ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Vijay K. Sharma, Leonard L.L. Yeo, Hock L. Teoh, Liang Shen, Bernard P.L. Chan, Raymond C. Seet, Aftab Ahmad, Vincent F. Chong, Prakash R. Paliwal Tags: Original Articles Source Type: research

Repeated Episodes of Ischemic Stroke over a Short Period in a Patient with Essential Thrombocythemia on Anticoagulant Therapy
A 69-year-old man who had essential thrombocythemia, for which he was taking no medications, suddenly developed aphasia and right hemiplegia and was admitted to the hospital. He was thought to have had an embolic stroke and was initially treated with warfarin. Although the international normalized ratio was in the therapeutic range, he had 3 additional ischemic stroke episodes with the same symptoms after the index stroke. Magnetic resonance angiographic examinations revealed serial changes in middle cerebral artery stenosis. After administration of an antiplatelet agent and hydroxyurea, he had no additional strokes.
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2012 Category: Neurology Authors: Masaki Naganuma, Kazuya Isoda, Shinsuke Nishi, Kiyotaka Ito, Teruyuki Hirano Tags: Case Reports Source Type: research