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Total 394 results found since Jan 2013.

Opioid Use and Its Relationship to Cardiovascular Disease and Brain Health: A Presidential Advisory From the American Heart Association
Circulation. 2021 Aug 19:CIR0000000000001007. doi: 10.1161/CIR.0000000000001007. Online ahead of print.ABSTRACTThe misuse of opioids continues to be epidemic, resulting in dependency and a recent upsurge in drug overdoses that have contributed to a significant decrease in life expectancy in the United States. Moreover, recent data suggest that commonly used opioids for the management of pain may produce undesirable pharmacological actions and interfere with critical medications commonly used in cardiovascular disease and stroke; however, the impact on outcomes remains controversial. The American Heart Association developed...
Source: Circulation - August 19, 2021 Category: Cardiology Authors: Sheryl L Chow Comilla Sasson Ivor J Benjamin Robert M Califf Wilson M Compton Elizabeth M Oliva Chester Robson Eduardo J Sanchez American Heart Association Source Type: research

Pulmonary Embolism and Cardiac Tamponade in Critical Care Patients with COVID-19; Telemedicine's Role in Developing Countries: Case Reports and Literature Review
CONCLUSIONS: During admission, both patients had sudden deterioration characterized by oxygen desaturation and hypotension necessitating inotropic support. As a result, for both patients, bedside echocardiography was performed by the attending intensivist. Echocardiographic findings showed cardiac tamponade and acute pulmonary embolism, respectively, which were confirmed by a cardiologist through telemedicine technology. Proper emergency management was initiated, and both patients recovered well. Limited bedside transthoracic echocardiography had a front-line impact on the treatment and outcome of the two patients with COV...
Source: Pain Physician - August 2, 2021 Category: Anesthesiology Authors: Islam Mohammed Sheata Scott Richard Smith Heba Kamel Giustino Varrassi Farnad Imani Abdolreza Dayani Dariusz Myrcik Ivan Urits Omar Viswanath Sameh Salem Taha Source Type: research

Efficient Roles of miR-146a in Cellular and Molecular Mechanisms of Neuroinflammatory Disorders: An Effectual Review in Neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, and ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Efficient Roles of miR-146a in Cellular and Molecular Mechanisms of Neuroinflammatory Disorders: An Effectual Review in Neuroimmunology
This study aims to provide a meticulous review regarding the roles of miR-146a in the pathogenesis and progression of several neuroinflammatory disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, temporal lobe epilepsy, and ischemic stroke, etc. The study also considers its eligibility for use as an ideal biomarker and therapeutic target in these diseases. The awareness of these mechanisms can facilitate the disease management/treatment, lead to patients' amelioration, improve the quality of life, and mitigate the risk of death.PMID:34293378 | DOI:10.1016/j.imlet.2021.07.004
Source: Immunology Letters - July 22, 2021 Category: Allergy & Immunology Authors: Mona Aslani Seyed Shahabeddin Mortazavi-Jahromi Abbas Mirshafiey Source Type: research

Sickle Cell Disease and Pain: Is it all Vaso-occlusive Crises?
Discussion: CP and NP should be assessed during routine care of sickle cell pain so that targeted therapies can be applied.
Source: The Clinical Journal of Pain - July 15, 2021 Category: Anesthesiology Tags: Original Articles Source Type: research

Real-world experience with the insertion of a new implantable cardiac monitor
ConclusionThe new BM III was inserted in typically less than 5 minutes until wound closure. A relevant number of insertions took place in a consultation room. Prophylactic antibiotics may be unnecessary, because no pocket infections were reported, although no antibiotic prophylaxis was used in one half of all cases (N = 229). In summary, the insertion with the new tool is fast and has a low risk of complications.
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real ‐life experience
ConclusionsThe frequency of comorbid PSED remains high (1/5 patient) despite improved awareness of these conditions. The association between poststroke complications and the presence of PSED emphasizes the need for standardized neurological and psychological evaluations at follow-up. These results foster the need to improve the management of addictive behaviors to reduce the burden of PSED.
Source: Brain and Behavior - May 5, 2021 Category: Neurology Authors: Yolaine Rabat, Richard Houeze, Sharmila Sagnier, Stephane Olindo, Mathilde Poli, Sabrina Debruxelles, Pauline Renou, Fran çois Rouanet, Sylvie Berthoz, Igor Sibon Tags: ORIGINAL RESEARCH Source Type: research

The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation
ConclusionsMethylnaltrexone use did not adversely affect pain control, opioid withdrawal effects, or AEs while providing effective RFL, regardless of age. These results suggest that age does not appear to influence the safety and efficacy of methylnaltrexone for OIC. Further research is needed to assess the impact of other factors that alter BBB permeability, such as dementia, stroke, or drug interactions, on the safety and efficacy of methylnaltrexone.Clinical Trial Registration NumbersStudy 302, NCT00402038; study 3200K1-4000, NCT00672477; study 3200K1-3356, NCT00529087; study 3201, NCT01186770.
Source: Drugs and Aging - March 31, 2021 Category: Geriatrics Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

IJERPH, Vol. 18, Pages 3089: Health-Related Quality of Life and Psychological Features in Post-Stroke Patients with Chronic Pain: A Cross-Sectional Study in the Neuro-Rehabilitation Context of Care
This study aims at exploring disability, health-related quality of life (HrQoL), psychological distress, and psychological features in post-stroke patients with chronic pain. An observational cross-sectional study involving 50 post-stroke patients (25 with chronic pain and 25 without pain) was conducted. The primary outcome was the self-reported level of disability and HrQoL which were both assessed through the Stroke Impact Scale 3.0. Both psychological distress and specific psychological features (i.e., self-efficacy, coping strategies, psychological flexibility, perceived social support) were examined. Post-stroke patie...
Source: International Journal of Environmental Research and Public Health - March 17, 2021 Category: Environmental Health Authors: Gandolfi Donisi Battista Picelli Val è Del Piccolo Smania Tags: Article Source Type: research