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Condition: Multiple Sclerosis

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Total 1656 results found since Jan 2013.

Fatigue and its relation to general cognition, social cognition and social activity in multiple sclerosis and stroke
CONCLUSIONS: Future studies ought to further explore the potentially complex nature of fatigue symptoms and their relationship with (socio-)cognitive performance and social activity in neurological populations.PMID:36782396 | DOI:10.1080/13546805.2023.2178399
Source: Cognitive Neuropsychiatry - February 14, 2023 Category: Psychiatry Authors: Tobias Lohaus Judith Witt Anne Sch ürmeyer Oliver T Wolf Patrizia Thoma Source Type: research

Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy
Fatigue is commonly reported in many neurologic illnesses, including multiple sclerosis, Parkinson disease, myasthenia gravis, traumatic brain injury, and stroke. Fatigue contributes substantially to decrements in quality of life and disability in these illnesses. Despite the clear impact of fatigue as a disabling symptom, our understanding of fatigue pathophysiology is limited and current treatment options rarely lead to meaningful improvements in fatigue. Progress continues to be hampered by issues related to terminology and assessment. In this article, we propose a unified taxonomy and a novel assessment approach to add...
Source: Neurology - January 21, 2013 Category: Neurology Authors: Kluger, B. M., Krupp, L. B., Enoka, R. M. Tags: All Clinical Neurology, Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke, Multiple sclerosis VIEWS & amp;amp; REVIEWS Source Type: research

Prediction of driving ability in people with relapsing-remitting multiple sclerosis using the stroke driver screening assessment - Akinwuntan AE, O'Connor C, McGonegal E, Turchi K, Smith S, Williams M, Wachtel J.
In this study, we investigated the accuracy with which the Stroke Driver Screenin...
Source: SafetyLit: All (Unduplicated) - January 25, 2014 Category: Global & Universal Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Stroke and MS
A man with MS thought his symptoms were a relapse but when he eventually sought medical help it turned out that he had had a stroke. He encourages people experiencing symptoms not to delay getting them assessed. Spokane Spokeman
Source: Multiple Sclerosis Trust - February 18, 2014 Category: Neurology Source Type: news

Factors that Influence Spasticity in Individuals with Stroke and Multiple Sclerosis
To describe the nature and impact of spasticity, determine factors that are perceived to change spasticity, and to examine the relationship between chronicity and impact of spasticity on activities of daily living in individuals with stroke and multiple sclerosis (MS).
Source: Archives of Physical Medicine and Rehabilitation - October 1, 2014 Category: Rehabilitation Authors: Janice Cheung, Jessica Hoang, Stephanie DiPoce, Amanda Rancourt, Amy Levine, Farooq Ismail, Chris Boulias, Chetan P. Phadke Source Type: research

Multiple Sclerosis
(MS) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer’s disease
Abstract Microglia undergo a process of activation in pathology which is controlled by many factors including neurotransmitters. We found that a subpopulation (11 %) of freshly isolated adult microglia respond to the muscarinic acetylcholine receptor agonist carbachol with a Ca2+ increase and a subpopulation of similar size (16 %) was observed by FACS analysis using an antibody against the M3 receptor subtype. The carbachol-sensitive population increased in microglia/brain macrophages isolated from tissue of mouse models for stroke (60 %) and Alzheimer’s disease (25 %), but not for glioma and multiple sclero...
Source: Anatomy and Embryology - December 18, 2014 Category: Anatomy Source Type: research

Similarities and differences in the experience of fatigue among people living with fibromyalgia, multiple sclerosis, ankylosing spondylitis and stroke
Conclusion and relevance to clinical practiceFatigue is commonly expressed by patients with long‐term illnesses. Variations in experience are related to the type of diagnosis. The disparity between experiences influences how patients managed and adjusted to the conditions of everyday life. The illness‐specific characteristics of fatigue warrant increased clinical awareness and may allow professionals to offer adequate information and establish effective methods of managing the condition. The feeling of invisibility and difficulty describing the experience of fatigue in particular highlights this need.
Source: Journal of Clinical Nursing - February 7, 2015 Category: Nursing Authors: Grethe Eilertsen, Heidi Ormstad, Marit Kirkevold, Anne M Mengshoel, Siv Söderberg, Malin Olsson Tags: Original Article Source Type: research

Drugs that activate brain stem cells may reverse multiple sclerosis
Two drugs already on the market — an antifungal and a steroid — may potentially take on new roles as treatments for multiple sclerosis. According to a study in Nature, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis. The study was partially funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - April 20, 2015 Category: Neurology Source Type: news

Drugs that activate brain stem cells may reverse multiple sclerosis in mice
Two drugs already on the market — an antifungal and a steroid — may potentially take on new roles as treatments for multiple sclerosis. According to a study in Nature, researchers discovered that these drugs may activate stem cells in the brain to stimulate myelin producing cells and repair white matter, which is damaged in multiple sclerosis. The study was partially funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - April 20, 2015 Category: Neurology Source Type: news

Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2 Basic Sciences
Conclusions— A clinically relevant dose of DMF demonstrates potent therapeutic efficacy and impressive 24 h therapeutic window of opportunity. This study merits further evaluation of this compound as potential treatment for ICH in humans.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Zhao, X., Sun, G., Zhang, J., Ting, S.-M., Gonzales, N., Aronowski, J. Tags: Animal models of human disease Basic Sciences Source Type: research

Comparison of upright balance in stroke, Parkinson and multiple sclerosis
The objective of the study was to assess the impact of MS, PD and ST on upright posture in eyes open condition and when visual and/or proprioceptive inputs are altered. Materials and methodsA total of 188 subjects with MS (n = 80), PD (n = 58) and ST (n = 50), mean age (SD), 57.9 (14.6) years, and 32 healthy subjects (HS) aged 53.7 (15.7) years were assessed by a stabilometric platform in a cross‐sectional study. ResultsCompared to HS, MS showed large deviations from normal performances with respect to magnitude (P < 0.001) and regularity (P < 0.05) of body sway irrespective of the altered sensory informa...
Source: Acta Neurologica Scandinavica - August 3, 2015 Category: Neurology Authors: D. Cattaneo, I. Carpinella, I. Aprile, L. Prosperini, A. Montesano, J. Jonsdottir Tags: Original Article Source Type: research

Immune interventions in stroke
Nature Reviews Neurology 11, 524 (2015). doi:10.1038/nrneurol.2015.144 Authors: Ying Fu, Qiang Liu, Josef Anrather & Fu-Dong Shi Approaches for the effective management of acute stroke are sparse, and many measures for brain protection fail. However, our ability to modulate the immune system and modify the progression of multiple sclerosis is increasing. As a result, immune interventions are currently being explored as therapeutic
Source: Nature Reviews Neurology - August 25, 2015 Category: Neurology Authors: Ying FuQiang LiuJosef AnratherFu-Dong Shi Tags: Review Source Type: research

An Open-Label Study to Assess Safety, Tolerability, and Effectiveness of Dextromethorphan/Quinidine for Pseudobulbar Affect (PBA) in Dementia, Stroke and Traumatic Brain Injury: PRISM II Combined Cohort Results for Patients Aged ≥65 Years
Introduction: Pseudobulbar affect (PBA) is a neurologic condition characterized by laughing and crying episodes that are uncontrollable, disruptive, and generally incongruent with social context and prevailing mood. PBA can occur secondary to a variety of unrelated neurologic conditions such as traumatic brain injury (TBI), stroke and Alzheimer's disease. It is estimated that approximately 9% of nursing home residents have symptoms suggestive of PBA.1,2 Dextromethorphan/quinidine (DM/Q) is the only treatment FDA-approved for PBA; approval was based on phase 3 studies in patients with PBA secondary to amyotrophic lateral sc...
Source: The American Journal of Geriatric Psychiatry - March 1, 2016 Category: Geriatrics Authors: Flora Hammond, David N. Alexander, Andrew J. Cutler, Stephen D'Amico, Rachelle S. Doody, William Sauve, Richard D. Zorowitz, Charles S. Davis, Paul Shin, Fred Ledon, Charles Yonan, Andrea E. Formella, Joao Siffert Source Type: research