Ocrelizumab for progressive MS trail results
Genentech have announced positive results from a phase III study of ocrelizumab in primary progressive MS. The ORATORIO trial was looking for reductions in progression, as measured by EDSS, sustained for 12 weeks. Little detail in the press release, but top line results will be presented at the ECTRIMS conference in October. PharmiWeb Ocrelizumab - drugs in development (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 27, 2015 Category: Neurology Source Type: news

Olympic hopeful with MS
Kadeena Cox from Leeds, who was diagnosed with MS last year, is hoping to take part in next year's Olympics, either as a sprinter or as a cyclist. Yorkshire Evening Post Exercises for people with MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 24, 2015 Category: Neurology Source Type: news

Potential PML vaccine being developed
Researchers say that they are developing a vaccine that helps the immune system fight the virus that causes PML - a serious brain infection that can be a side effect of some disease modifying drugs. The approach has so far only been studied in a handful of humans. University of Zurich PML (Progressive multifocal leukoencephalopathy) - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 23, 2015 Category: Neurology Source Type: news

Measuring progression in trials
Research using the international MSBase registry suggests that trials that are using disease progression as an outcome measure should be longer. About a quarter of people assessed as having a permanent increase in disability on the EDSS scale after three months were found to have improved in the subsequent 10 years. News Medical Expanded Disability Status Scale (EDSS) - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 22, 2015 Category: Neurology Source Type: news

NICE social care guidelines published
In its first guideline for social care says carer visits to older or disabled people living at home should be at least 30 minutes and that people should see the same carer(s) and not different ones each time. It also recommends more training for carers and better coordination with health services. NICE recognises that meetings these guidelines will cost more. NICE BBC Guardian (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 22, 2015 Category: Neurology Source Type: news

New progressive MS research grants
The Progressive MS Alliance has awarded 11 more research grants for studies around the world, including a study of mitochondria at the University of Edinburgh. In its role in connecting similar projects around the world, a study targeting microglia in progressive MS at Imperial College in London has been matched with a team working in Paris. National MS Society (USA) Progressive MS - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 21, 2015 Category: Neurology Source Type: news

Disease modifying drugs
A Cochrane review of disease modifying drugs for relapsing MS found that the best at reducing relapse in the first two years of treatment were alemtuzumab, mitoxantrone, natalizumab and fingolimod. The best at reducing the build up of disability in the same period were mitoxantrone, alemtuzumab, and natalizumab. The review criticises the lack of long-term evidence for efficacy and side effects. MS News Today Disease modifying drugs for relapsing MS - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 21, 2015 Category: Neurology Source Type: news

What affects quality of life in MS?
Czech research into factors that have a negative effect on quality of life for people with MS identified the label of MS, cognitive symptoms, sexual dysfunction and family problems. The researchers also point out the failings in the scales used to measure quality of life. MS News Today Cognition and cognitive symptoms - A to Z of MS Sexual issues - A to Z of MS Living with progressive MS in the family - Open Door article (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 20, 2015 Category: Neurology Source Type: news

MS Brain Health Symposium - pre-ECTRIMS - 6 October 2015 - Barcelona
This interactive symposium will discuss the evidence base for such an approach in MS, and the potential impact on health and economic outcomes. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 17, 2015 Category: Neurology Source Type: news

Allied Health Professionals voice rising concern over therapeutic services for people with long-term neurological conditions
Today the MS Trust publishes a joint report highlighting Allied Health Professionals' (AHPs) views on the pressures and challenges facing neuro-specialist therapy services in today's NHS. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 15, 2015 Category: Neurology Source Type: news

Effects of benefit changes
An MS Society survey suggests that half of people applying for ESA and a third having interviews for PIP said their health was damaged as a result. The results also showed people cutting down on spending on food, transport and socialising with one in 10 saying they spent less on their healthcare. Guardian Scotsman Benefits - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 13, 2015 Category: Neurology Source Type: news

Southport Golf Day
Long-term MS Trust supporter Rick Halsall is holding a Golf Day on Friday 25 September in aid of the MS Trust. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 10, 2015 Category: Neurology Source Type: news

Cladribine comeback
Based on "new data and additional analyses of the compound's benefit-risk profile", Merck is planning to submit cladribine to the EMA for licensing. The development of the drug was stopped in 2011 following potential cancer risks. Merck press release Reuters Cladribine - A to A of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 10, 2015 Category: Neurology Source Type: news

Good luck to our Great North Runners
Good luck to our team of 50 MS Trust runners taking part in the Great North Run on Sunday. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 10, 2015 Category: Neurology Source Type: news

Melatonin and seasonal fluctuations
American research suggests that the seasonal fluctuation in symptoms (fewer relapses in autumn and winter) may be due to the protective effects of melatonin, which is produced by the body when not exposed to sunlight. Science News Havard Gazette Relapses - A to A of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 9, 2015 Category: Neurology Source Type: news

Smoking leads to earlier transition to secondary progressive MS
A study has reported that smokers who continued to smoke after being diagnosed with relapsing remitting MS reached the transition to secondary progressive MS more quickly than those who gave up smoking. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 9, 2015 Category: Neurology Source Type: news

Smoking and progression
Swedish research found that people diagnosed with relapsing remitting MS who continued to smoke reached the transition to secondary progressive quicker than those people who had stopped after diagnosis. Medical Daily Smoking - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 7, 2015 Category: Neurology Source Type: news

Secondary progressive MS book success in BMA awards
The MS Trust book Secondary progressive multiple sclerosis was highly commended in the BMA Patient Information Awards, which were announced last night (7 September). (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 7, 2015 Category: Neurology Source Type: news

MS Trust takes part in Remember a Charity Week 2015, encouraging people to leave a charitable gift in their Will
This week the MS Trust is joining 140 other charities in support of this year's Remember A Charity Week. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 6, 2015 Category: Neurology Source Type: news

Take part in a survey on Living with Medicines
Do you live in the UK? Do you regularly use prescription medications? Are you 18 years or over? (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 3, 2015 Category: Neurology Source Type: news

Telephone support for symptoms
An American study found that a telephone delivered education programme for people with MS with pain, fatigue and depressed mood reduced the impact of symptoms by about half. National MS Society (USA) Pain - A to Z of MS Fatigue - A to Z of MS Depression - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 1, 2015 Category: Neurology Source Type: news

Final call for entries for the QuDoS Awards
If you are a health professional, don't forget to nominate your colleagues for the 2015 QuDoS in MS Awards. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - September 1, 2015 Category: Neurology Source Type: news

Breastfeeding and relapses
Women who only breastfed in the two months following a birth had fewer relapses in the six months postpartum than women who used other approaches. Medical Xpress Breastfeeding - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 30, 2015 Category: Neurology Source Type: news

Impact of parental MS on childhood development
A Canadian study found that having a parent with MS did not affect a 5 year old's physical health and wellbeing, social competence, emotional maturity, language and cognitive development, and communication skills and general knowledge. However, having a parent with mental health issues (inc anxiety or depression) did have a negative effect. Canadian MS Society Talking with your kids about MS Depression - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 30, 2015 Category: Neurology Source Type: news

Latest figures showing variation in access to neurology services come as no surprise
The publication of the National Neurology Intelligence Network's first ever figures on neurological outpatient appointments in England brings both good and bad news. The report is the latest to show that access to neurology services and specialists varies significantly across the country. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 27, 2015 Category: Neurology Source Type: news

Link between vitamin D and MS onset
People with genes that cause them to have low levels of vitamin D are more likely to develop MS according to new research (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 25, 2015 Category: Neurology Source Type: news

Vitamin D and MS onset
A study has found that people with genes that cause them to have low levels of vitamin D were more to develop MS. The researchers call for more studies to see if supplementation delays onset of MS. Daily Telegraph Guardian MS Research Australia Vitamin D - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 24, 2015 Category: Neurology Source Type: news

Medical cannabis and Sativex
Article looking at the role of cannabis in treating MS, the difficulty in getting access to Sativex and issues around illegality. New Statesman Cannabis - A to Z of MS Sativex - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 17, 2015 Category: Neurology Source Type: news

Sleep disturbance and fatigue
A review of previous studies by the Kessler Foundation concludes that sleep disturbances were a major element of MS related fatigue. Medical News Today Sleep - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 17, 2015 Category: Neurology Source Type: news

Applying for PIP
Amy Mackelden, who has MS, writes about the demeaning and dehumanising effects of applying for Personal Independence Payments (PIP) and going through the tribunal process when the application was rejected. New Statesman Benefits - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 16, 2015 Category: Neurology Source Type: news

Fingolimod (Gilenya) and PML
A third case of the brain infection PML has been reported in someone taking fingolimod. This person had not been taken immune suppressing drugs for MS, but had had chemotherapy and radiotherapy for cancer. Novartis Fingolimod (Gilenya) - A to Z of MS PML (Progressive multifocal leukoencephalopathy) - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 16, 2015 Category: Neurology Source Type: news

MS Trust Christmas cards now on sale
Our Christmas webshop is open with a fantastic selection of designs, from yummy cupcakes to traditional robins. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 12, 2015 Category: Neurology Source Type: news

Exercise benefits for children with MS
In a small study of children with MS and those without MS who had experienced a single neurologic attack, moderate physical activity was associated with less fatigue, and strenuous activity was associated with fewer relapses and less disease activity seen on MRI brain scans. MedPage Today Children with MS - A to Z of MS Exercise and MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 11, 2015 Category: Neurology Source Type: news

MS drugs during pregnancy
A review of different studies looking at the effects of Betaferon, teriflunomide and natalizumab on women with MS who become pregnant. Although the numbers are relatively small, Results suggest that there was no increase in spontaneous abortions or birth abnormalities. MS Research Australia Pregnancy - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 10, 2015 Category: Neurology Source Type: news

Carers struggling to take holidays
Cuts to social services are not helping carers. A survey by the Carers Trust found that two thirds of carers had not been able to go away on a break this year, with a third saying they had not even had a full day off to themselves. BBC Carers - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 8, 2015 Category: Neurology Source Type: news

PML risk with Gilenya prompts update to US prescribing information
The FDA has announced that it will update the information for Gilenya (fingolimod) after two possible cases of PML in people with MS taking this disease modifying drug in the USA. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 5, 2015 Category: Neurology Source Type: news

Active management strategy required for newer MS drugs
An Australian neurologist discusses the need to monitor people with MS taking disease modifying drugs to avoid complications. Medical News Today Proactive treatment of relapsing MS - Open Door (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 2, 2015 Category: Neurology Source Type: news

Draft recommendations on vitamin D published
The Scientific Advisory Committee on Nutrition (SACN), an independent body which advises the Government on diet, nutrition and health matters, have published their draft recommendations on vitamin D which are now out for public consultation until 23 September. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 2, 2015 Category: Neurology Source Type: news

Flash sale on RideLondon 2016 places - FREE to register!
If you would like to take part in the Prudential RideLondon-Surrey 100 next year, we are offering a Flash Sale on our 2016 places. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 2, 2015 Category: Neurology Source Type: news

Vitamin D recommendations - consultation
The Scientific Advisor Committee on Nutrition has published draft recommendations on vitamin D intake that are out to public consultation until 23 September. This guidance is based on vitamin D levels for maintaining musculoskeletal health. Evidence for a role in MS was considered but insufficient evidence was found to draw firm conclusions. Scientific Advisor Committee on Nutrition draft report Guardian Independent Vitamin D - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - August 1, 2015 Category: Neurology Source Type: news

Good luck to our RideLondon team
Best of luck to our 8 MS Trust RideLondon cyclists who will be taking on the 100 mile cycle challenge through London and Surrey tomorrow. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 31, 2015 Category: Neurology Source Type: news

Calling all MS health professionals: enter or nominate colleagues for the 2015 QuDos in MS awards!
There are just six weeks left to enter and make your nominations for the first ever QuDos in MS awards – the awards that highlight innovation and excellence in MS services. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 28, 2015 Category: Neurology Source Type: news

Beach wheelchairs
James Coke, who has primary progressive MS and who likes swimming in the sea, highlights the difficulty in finding beach wheelchairs in the UK and how the situation is better in Mallorca. Guardian Travelling and holidays (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 27, 2015 Category: Neurology Source Type: news

Summer fun day in Wigan
If you live in the Wigan area why not pop along to the Springfield Hotel on 23rd August for a summer fun day raising money for the MS Trust? (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 27, 2015 Category: Neurology Source Type: news

Study into MS bowel dysfunction
Being run by Dr Sue Woodward, Florence Nightingale Faculty of Nursing and Midwifery, King's College London (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 26, 2015 Category: Neurology Source Type: news

Project to design a protocol for presenting MS medication risks and benefits
Collaborative study between Royal Holloway, University of London and King's College Hospital NHS Foundation Trust (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 26, 2015 Category: Neurology Source Type: news

Personal care budgets
A woman with MS in Norfolk who has a personal care budget and the chief executive of a charity that helps people manage these funds talk about the benefits of the approach and the dangers of cuts to social care funding. Eastern Daily Press Individual budgets - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 26, 2015 Category: Neurology Source Type: news

Off-Patent Drugs Bill
A private members bill seeking to allow access to drugs off patent is going through parliament. A previous attempt before the election failed. This story focusses on a breast cancer treatment but treatment of MS is also briefly mentioned. Independent MS-SMART trial - investigating repurposing drugs for secondary progressive MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 23, 2015 Category: Neurology Source Type: news

MS Trust commissioned research on transition to secondary progressive MS published
MS Trust funded research exploring the support people need during the transition from relapsing remitting to secondary progressive MS has been published today in BMJ Open. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 22, 2015 Category: Neurology Source Type: news

Predictive factors for MS in CIS
Spanish research found that the number of lesions was the best indicator that someone with CIS would develop MS. Oligoclonal bands were a 'medium-impact prognostic factor' and gender and location of lesions less indicative. Disease modifying drug treatment extended the time before MS diagnosis. MSIF Clinically isolated syndrome (CIS) - A to Z of MS (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - July 21, 2015 Category: Neurology Source Type: news