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Drug: Estradiol
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Total 251 results found since Jan 2013.
Immunomodulatory role of estrogen in ischemic stroke: neuroinflammation and effect of sex
Although estrogen is predominantly related to the maintenance of reproductive functioning in females, it mediates various physiological effects in nearly all tissues, especially the central nervous system. Clinical trials have revealed that estrogen, especially 17β-estradiol, can attenuate cerebral damage caused by an ischemic stroke. One mechanism underlying this effect of 17β-estradiol is by modulating the responses of immune cells, indicating its utility as a novel therapeutic strategy for ischemic stroke. The present review summarizes the effect of sex on ischemic stroke progression, the role of estrogen as an immuno...
Source: Frontiers in Immunology - April 25, 2023 Category: Allergy & Immunology Source Type: research
Use of combined hormonal contraception and stroke: A case-control study of the impact of migraine type and estrogen dose on ischemic stroke risk
CONCLUSIONS: Overall stroke risk in our cohort of CHC users was low. When CHCs are used in those with migraine, formulations containing ≤30 μg EE are preferred. Shared decision-making should include discussions about ischemic stroke risks in patients with migraine, even those without aura.PMID:36752588 | DOI:10.1111/head.14473
Source: Headache - February 8, 2023 Category: Neurology Authors: Pelin Batur Meng Yao Julia Bucklan Payal Soni Aarushi Suneja Ruth Farrell Maryann Mays Source Type: research
Prenatal alcohol exposure exacerbates acute sensorimotor deficits and impedes long-term behavioral recovery resulting from adult-onset cerebrovascular ischemic stroke
CONCLUSIONS: Our data indicate that PAE contributes to adverse effects on brain health and to decreased resiliency to a common adult-onset neurovascular disease.PMID:36203340 | DOI:10.1111/acer.14952
Source: Alcoholism, Clinical and Experimental Research - October 7, 2022 Category: Addiction Authors: Shameena Bake David A Hurst Rajesh C Miranda Farida Sohrabji Source Type: research
Menopausal hormone therapy with conjugated equine estrogen is associated with a higher risk of hemorrhagic stroke than therapy with estradiol: a retrospective population-based cohort study
Estrogen therapy is prescribed for women without a uterus. For women with intact uteri, progestogens should be added to protect against endometrial hyperplasia. Different estrogen profiles may cause different side effects and beneficial clinical outcomes [1]. Different forms of estrogen also have different serum E2 concentrations; a previous study demonstrated that 1 mg E2 was equivalent to 0.4 mg CEE [1]. Progestin includes medroxyprogesterone acetate (MPA) and norethindrone acetate (NE). In Taiwan, the most common MHT for patients with an intact uterus are CEE (0.625 mg) or E2 (2 mg) combined with 5 mg MPA or 1 mg NE [2,3].
Source: Maturitas - August 1, 2022 Category: Primary Care Authors: Wei-Chuan Chang, Jen-Hung Wang, Dah-Ching Ding Tags: Original article Source Type: research
Oral contraceptives and stroke: Foes or friends
Front Neuroendocrinol. 2022 Jul 20:101016. doi: 10.1016/j.yfrne.2022.101016. Online ahead of print.ABSTRACTIncidents of strokes are increased in young women relative to young men, suggesting that oral contraceptive (OC) use is one of the causes of stroke among young women. Long-term exposures to the varying combinations of estrogen and progestogen found in OCs affect blood clotting, lipid and lipoprotein metabolism, endothelial function, and de novo synthesis of neurosteroids, especially brain-derived 17β-estradiol. The latter is essential for neuroprotection, memory, sexual differentiation, synaptic transmission, and beh...
Source: Frontiers in Neuroendocrinology - July 23, 2022 Category: Endocrinology Authors: Varun Reddy Megan Wurtz Shahil H Patel Micheline McCarthy Ami P Raval Source Type: research
