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Total 470 results found since Jan 2013.

Sig1R Stimulates Cancer Cell Invasiveness
In this study, we found that Sig1R dynamically controls the membrane expression of the human voltage-dependent K+ channel human ether-à-go-go-related gene (hERG) in myeloid leukemia and colorectal cancer cell lines. Sig1R promoted the formation of hERG/β1-integrin signaling complexes upon extracellular matrix stimulation, triggering the activation of the PI3K/AKT pathway. Consequently, the presence of Sig1R in cancer cells increased motility and VEGF secretion. In vivo, Sig1R expression enhanced the aggressiveness of tumor cells by potentiating invasion and angiogenesis, leading to poor survival. Collectively, our findin...
Source: Cancer Research - January 31, 2016 Category: Cancer & Oncology Authors: Crottes, D., Rapetti–Mauss, R., Alcaraz–Perez, F., Tichet, M., Gariano, G., Martial, S., Guizouarn, H., Pellissier, B., Loubat, A., Popa, A., Paquet, A., Presta, M., Tartare–Deckert, S., Cayuela, M. L., Martin, P., Borgese, F., Soriani, Tags: Molecular and Cellular Pathobiology Source Type: research

Post–Gastric Bypass Hypoglycemia
Abstract Obesity is a major public health problem worldwide. Obesity-related illnesses, such as coronary heart disease, type 2 diabetes, hypertension, dyslipidemia, stroke, sleep apnea, and several forms of cancer (endometrial, breast, and colon), contribute to a significant number of deaths in the USA. Bariatric surgery, including the Roux-en-Y gastric bypass (RYGB) procedure, has demonstrated significant improvements in obesity and obesity-related co-morbidities and is becoming more popular as the number of obese individuals rises. Despite the reported benefits of bariatric surgery, there are potential complica...
Source: Current Diabetes Reports - February 11, 2016 Category: Endocrinology Source Type: research

Optimizing Acute Pain Management in the Obese Patient: Treatment and Monitoring Considerations
THE CHALLENGES OF PROVIDING SAFE AND EFFECTIVE pain management for patients with obesity are present throughout the perioperative setting. Obesity is associated with chronic medical comorbidities, such as coronary artery disease, stroke, chronic kidney disease, nonalcoholic fatty liver disease, and type 2 diabetes.1 Other obesity-associated comorbidities include breast, endometrial, ovarian, colorectal, esophageal, kidney, pancreatic, and prostate cancers, chronic back pain, and osteoarthritis.1 The demand for bariatric surgery has risen markedly in recent years with the total number of surgeries performed in the United St...
Source: Journal of PeriAnesthesia Nursing - February 27, 2016 Category: Nursing Authors: Maureen F. Cooney Tags: Pain Care Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts Epidemiology
Conclusions Off-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Zhou, Y., Li, W., Herath, C., Xia, J., Hu, B., Song, F., Cao, S., Lu, Z. Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research

Help! My daughter has become a vegetarian!
Q: My daughter has decided to follow a vegetarian diet. Do I need to worry about protein deficiency? ~ Worried Mom This is one of the most common questions that pediatricians are asked. A vegetarian diet, and especially one that includes fish, can be a very healthy option. Learn more about nutrition for vegetarians and ways your family can shift to a vegetarian diet. Q: Does my child need to eat meat to get enough protein? Complete nutrition, including adequate protein, can easily be obtained without eating meat. Meat is completely unnecessary if a diet is high in fruits, vegetables, nuts, beans, fish, whole grains, eggs...
Source: Thrive, Children's Hospital Boston - April 6, 2016 Category: Pediatrics Authors: Carolyn Sax Tags: Parenting Teen Health Dr. Carolyn Sax vegetarian Source Type: news

Hemodynamics of mesenteric traction syndrome measured by FloTrac sensor.
CONCLUSIONS: The SVV results indicate that fluid loading is not that optimal treatment against hypotension of MTS and that it is also important to consider the use of a vasoconstrictor. FloTrac is therefore useful for making an appropriate decision on the treatment strategy for MTS. PMID: 27041263 [PubMed - in process]
Source: Clinical Colorectal Cancer - April 6, 2016 Category: Cancer & Oncology Authors: Takahashi H, Shida D, Tagawa K, Suzuki T Tags: J Clin Anesth Source Type: research

USPSTF publishes recommendation on taking aspirin to prevent heart attack, stroke, and colorectal cancer
(American College of Physicians) The US Preventive Services Task Force recommends that people who are 50-69 years old, have increased risk of cardiovascular disease (CVD), and who are not at increased risk for bleeding, consider taking aspirin for primary prevention of CVD and colorectal cancer. The full recommendation and evidence reviews are published in Annals of Internal Medicine.
Source: EurekAlert! - Cancer - April 11, 2016 Category: Cancer & Oncology Source Type: news

Daily aspirin 'protects against heart attack and colon cancer' in certain patients
The US Preventative Services Task Force recommends people aged 50 to 59 who are at risk of cardiovascular disease take a daily dose of aspirin to lower their risk of heart attack, stroke and colon cancer.
Source: the Mail online | Health - April 11, 2016 Category: Consumer Health News Source Type: news

Pop a daily aspirin to help prevent heart attacks, stroke and colon cancer, expert panel says
Taking a daily dose of aspirin can help prevent both heart disease and colorectal cancer in adults ages 50 to 69 who are at an increased risk for cardiovascular problems, an independent panel of medical experts said Monday. The final recommendation from the U.S. Preventive Services Task Force said that low-dose aspirin — typically, 81 mg […]
Source: Washington Post: To Your Health - April 11, 2016 Category: Consumer Health News Authors: Lena H. Sun Tags: health cancer Source Type: news

Aspirin a day may push death away, new study says
Taking an aspirin a day might help prevent heart attacks, stroke and colon cancer.
Source: CNN.com - Health - April 12, 2016 Category: Consumer Health News Source Type: news

Pop a daily aspirin to help prevent heart attacks, stroke and colon cancer, expert panel says
Taking a daily dose of aspirin can help prevent both heart disease and colorectal cancer in adults ages 50 to 69 who are at an increased risk for cardiovascular problems, an independent panel of medical experts said Monday. The final recommendation from the U.S. Preventive Services Task Force said that low-dose aspirin — typically, 81 mg […]
Source: Washington Post: To Your Health - April 11, 2016 Category: Consumer Health News Authors: Lena H. Sun Tags: cancer health newsletter Source Type: news

Help! My daughter has become a vegetarian!
Q: My daughter has decided to follow a vegetarian diet. Do I need to worry about protein deficiency? ~ Worried Mom This is one of the most common questions that pediatricians are asked. A vegetarian diet, and especially one that includes fish, can be a very healthy option. Learn more about nutrition for vegetarians and ways your family can shift to a vegetarian diet. Q: Does my child need to eat meat to get enough protein? Complete nutrition, including adequate protein, can easily be obtained without eating meat. Meat is completely unnecessary if a diet is high in fruits, vegetables, nuts, beans, fish, whole grains, eggs...
Source: Thrive, Children's Hospital Boston - April 6, 2016 Category: Pediatrics Authors: Carolyn Sax Tags: Parenting Teen Health Dr. Carolyn Sax vegetarian Source Type: news

Daily low-dose aspirin may help combat cancer
Conclusion The systematic review looked at 47 studies and attempted to combine the results, looking for evidence of a beneficial effect of low-dose aspirin on risk of death in people already diagnosed with cancer. The few RCTs identified – the best-quality evidence – did not provide conclusive evidence that aspirin improves survival rates. The rest of the studies were observational in nature, so cannot prove that aspirin reduces the risk of death from cancer. The only significant results were for a 24% reduction in risk of death from colon cancer, and a possible 11% reduced risk of death from prostate cancer. However,...
Source: NHS News Feed - April 22, 2016 Category: Consumer Health News Tags: Cancer Medication Source Type: news

Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study
Conclusions Advanced periodontitis was associated with a 2.5-fold increase in smoking-related cancers among never smokers. Periodontitis may impact cancer risk through system immune dysregulation. Further studies need to examine the immune impact of advanced periodontitis on cancer, especially for cancers known to be caused by smoking.
Source: Annals of Oncology - April 20, 2016 Category: Cancer & Oncology Authors: Michaud, D. S., Kelsey, K. T., Papathanasiou, E., Genco, C. A., Giovannucci, E. Tags: epidemiology Source Type: research