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Cancer: Childhood Cancer

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Total 243 results found since Jan 2013.

Economic growth as an underlying probable systemic driver for childhood obesity in South Africa: A Joinpoint regression and ecological analysis over 10 years
CONCLUSIONS: An increase in childhood and adolescent obesity over time was observed, while trend associations between obesity and EGIs exist.PMID:33944743 | DOI:10.7196/SAMJ.2021.v111i3.14669
Source: South African Medical Journal - May 4, 2021 Category: African Health Authors: P T Pisa N M Pisa P Chikandiwa A Chikandiwa Source Type: research

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology.
CONCLUSIONS: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate- or low-dose exposed groups, with some not altogether consistent evidence suggesting dose response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose response. Nuclear cata...
Source: International Journal of Radiation Biology - January 22, 2021 Category: Radiology Tags: Int J Radiat Biol Source Type: research

An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.
Abstract ∆ 9 -Tetrahydrocannabinol (∆9 -THC), the active phytocannabinoid in cannabis, is virtually an adjunct to the endogenous endocannabinoid signaling system. By interacting with G-protein-coupled receptors CB1 and CB2, ∆9 -THC affects peripheral and central circulation by lowering sympathetic activity, altering gene expression, cell proliferation, and differentiation, decreasing leukocyte migration, modulating neurotransmitter release thereby modulating cardiovascular functioning, tumorigenesis, immune responses, behavioral and locomotory activities respectively. ∆ 9 -THC is effective in suppressing c...
Source: Current Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Authors: Mathew B, Harilal S, Musa A, Kumar R, Parambi DGT, Jose J, Uddin MS, Shah MA, Behl T, Unnikrishnan MK Tags: Curr Drug Targets Source Type: research

Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review.
Conclusions: More effort is needed to identify what fetal and maternal factors are associated with low birth weight and IBS. A well-executed prospective birth cohort with a collection of bio-samples and functional data will provide a better understanding of how adversity and the interplay between genetics, epigenetics, and numerous risk factors affect the development of IBS. PMID: 32989183 [PubMed]
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body's natural production of alpha-ketoglutarate extended the lives of mice harboring DIPG tumors by slowing the growth of the cancer cells.
Source: EurekAlert! - Cancer - August 18, 2020 Category: Cancer & Oncology Source Type: news