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Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke by activating the AKT/mTOR signaling pathway to suppress autophagy.
In conclusion, our findings indicated that DF treatment can reduce brain damage and inhibit apoptosis and autophagy by activating the Akt-mTOR signaling pathway in ischemic stroke.
PMID: 32781091 [PubMed - as supplied by publisher]
Source: Brain Research - August 7, 2020 Category: Neurology Authors: Zhang Y, He Q, Yang M, Hua S, Ma Q, Guo L, Wu X, Zhang C, Fu X, Liu J Tags: Brain Res Source Type: research
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats
Piper nigrum L. and Piper longum L. consist a classic formula in traditional Chinese Hui medicine and are widely used in treatment of stroke. To examine the therapeutic effect of neuron injury after apoplexy, we used a permanent middle cerebral artery occlusion model in rats to investigate the effects of dichloromethane fraction (DF) of Piper nigrum L. and Piper longum L.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2018 Category: Neurology Authors: Shiyao Hua, Bing Wang, Rong Chen, Yuanbin Zhang, Yiwei Zhang, Tingting Li, Lin Dong, Xueyan Fu Source Type: research
How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you…
Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China.
I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1
We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004.
Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news
Godly gift for arthritis pain
Big Pharma is at it again… Creating and selling a drug that causes thousands of heart attacks and strokes each year.
In 2015, the FDA asked drug makers to strengthen their warning labels.
Since then, most have listed their dangerous side effects on the bottle.
But one manufacturer thought they didn’t have to warn people about their dangerous drug.
They marketed their product as a “unique” breakthrough. They even published studies promising it was “safe for long-term use.” 1
The drug is a 7-year-old arthritis drug called Actemra. It’s made by the Swiss pharmaceutical company Roche.
...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
You're Eating Fish All Wrong
By Cynthia Sass, MPH, RD
Eating fish has been tied with lower rates of heart disease, stroke, depression and Alzheimer's disease. But how you eat it may be the real key to reaping its benefits. Recent research from University of Pittsburgh School of Medicine concluded that study volunteers who regularly ate fish had larger brain volumes in regions associated with memory and cognition, but only if the fish baked or broiled, not fried.
Baking and broiling are also better for your waistline. For example, a dozen fried shrimp can pack 280 calories, versus a mere 85 calories for 12 shrimp that have been steamed or broiled. To...
Source: Healthy Living - The Huffington Post - November 2, 2014 Category: Consumer Health News Source Type: news
A Cross Between Ginger and a Carrot
I woke up with the sunlight … and birds singing so loudly I thought they were in the room with me.
I walked out of my cottage to a warm breeze, and sat down to a delicious breakfast: fresh fruit, banana pancakes and a tall glass of jackfruit juice.
I made my way to my friends Westi and Lelir’s house, where he greeted me with a long “pick and hoe” garden cultivating tool. Westi said, “Ready?” smiling, holding out the long handle towards me.
We walked up the steep hill behind his home to his private herb garden. I wondered what we might harvest today.
He stopped in front of a row of very tall plants and smiled, ...
Source: Al Sears, MD Natural Remedies - October 13, 2014 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Hormone Health Source Type: news
Turmeric: Bali’s Anti-Cancer Tonic
I’m always happy to find things in my travels to bring back to you. Today I want to tell you about a miracle of nature called turmeric.
Turmeric has been used to treat a wide variety of conditions.
You can read about it in-depth in my latest book, Healing Herbs of Paradise.
The roots of this exotic leafy plant contain curcumin, a very powerful antioxidant that also has remarkable anti-inflammatory properties.1,2,3
What Does Curcumin Do?
Curcumin neutralizes free radicals… those nasty little chemicals that travel through your body and cause damage to healthy cells and cell membranes.
Which means curcumin effectivel...
Source: Al Sears, MD Natural Remedies - May 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news
Turmeric: Nature ’s Miracle Root for Disease
My friends Lelir and Westi in Bali don’t like to go to doctors. Nature is their pharmacy.
You see, Lelir is a Balian. That means “herbal healer.”
And Westi’s plantation is bursting with healing plants.
But one plant stands out above all the others. Lelir uses it to make a daily immune-boosting elixir as well as an anti-aging facial scrub. Balians use it as an antibiotic and for liver support. They boil it with milk and sugar to treat the common cold and allergies. Rural doctors make it into a paste with lime to ease sore joints. They make drinks to treat fevers and stomach pain. They mix it wi...
Source: Al Sears, MD Natural Remedies - September 20, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news
Anti-inflammatory activity and chemical composition of dichloromethane extract from Piper nigrum and P. longum on permanent focal cerebral ischemia injury in rats
Abstract White pepper (Piper nigrum L.) and long pepper (Piper longum L.) belong to family Piperaceae and are commonly used as household spices and traditional medicine worldwide, specifically in China and Southeast Asia. In Traditional Chinese Hui Medicine, these herbs are widely used for treatment of stroke. Our present study investigated effects of these herbs on inflammation in rat model with cerebral ischemia. After subjecting the rats to permanent middle cerebral artery occlusion (pMCAO) for 6 h, at doses of 100 and 200 mg/kg, dichloromethane fraction from white pepper and long pepper, respectively, was intragastrica...
Source: Revista Brasileira de Farmacognosia - June 26, 2017 Category: Drugs & Pharmacology Source Type: research
Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion
This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders
Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These day...
Source: Frontiers in Pharmacology - November 10, 2022 Category: Drugs & Pharmacology Source Type: research
When It ’ s This Hot, What Should You Eat?
As temperatures continue to climb in what could become the northern hemisphere’s hottest summer on record, the summer of 2023 is all about finding any way to stay cool. And that includes turning to foods that will hopefully provide a little relief. While not a panacea for the heat, body-cooling foods and no-cook diets could help to lower body temperature and make record-breaking heat waves a little more bearable..
Living safely in consistently hot climates means staying hydrated, especially with chilled drinks or fruits. But there are other, more physiologically based—and even surprising—ways to make your...
Source: TIME: Health - July 20, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized climate change Diet & Nutrition healthscienceclimate Source Type: news
This Overlooked Nutrient May Be The Key To Brain Power
Aging is inevitable. But have you noticed that some very elderly people still don’t miss a thing?
Some of my patients fall into this category. I’ve worked with many centenarians who remain quick-witted, with keen memories and focus.
You can be one of these people, too — an all-star senior…
Inside all of you, your cells are constantly busy dividing up to two trillion times per day. The new cells replace old, damaged, or dead cells and help you live, grow and thrive.
Human cell lines have built-in mortality. As your cells divide, there’s a limit at which their limit is reached.
There’s an internal mechanism o...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Brain Health Source Type: news
