Filtered By:
Management: Funding

This page shows you your search results in order of relevance. This is page number 15.

Order by Relevance | Date

Total 633 results found since Jan 2013.

Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (“Neuroprotection”)
Abstract The term “neuroprotection” is often misused, overused, or misunderstood. A reasonable definition of neuroprotection refers to the preservation of “neuronal structure and/or function.” Although our knowledge about the cellular and molecular mechanisms of neurodegeneration has expanded, experimental systems and animal models that mimic the process or allow translation into clinical success remain limited. This editorial discusses reasons for this gap and strategies to close it. Experimental models can only mirror certain aspects of disease mechanisms in humans. Therefore, findings in these models ne...
Source: Neurotherapeutics - March 14, 2015 Category: Neurology Source Type: research

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study
Publication date: Available online 7 May 2015 Source:The Lancet Author(s): Renate B Schnabel , Xiaoyan Yin , Philimon Gona , Martin G Larson , Alexa S Beiser , David D McManus , Christopher Newton-Cheh , Steven A Lubitz , Jared W Magnani , Patrick T Ellinor , Sudha Seshadri , Philip A Wolf , Ramachandran S Vasan , Emelia J Benjamin , Daniel Levy Background Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years. Methods We investigated trends in incidence, prevalence, and risk factors for atrial fibrillat...
Source: The Lancet - May 9, 2015 Category: Journals (General) Source Type: research

Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease. Further research is needed to identify determinants of muscular strength and to test whether improvement in strength reduces mortality and cardiovascular disease. Funding Full funding sources listed at end of paper (see Acknowledgments).
Source: The Lancet - May 15, 2015 Category: Journals (General) Source Type: research

Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data
Publication date: Available online 28 May 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Kunihiro Matsushita , Josef Coresh , Yingying Sang , John Chalmers , Caroline Fox , Eliseo Guallar , Tazeen Jafar , Simerjot K Jassal , Gijs W D Landman , Paul Muntner , Paul Roderick , Toshimi Sairenchi , Ben Schöttker , Anoop Shankar , Michael Shlipak , Marcello Tonelli , Jonathan Townend , Arjan van Zuilen , Kazumasa Yamagishi , Kentaro Yamashita , Ron Gansevoort , Mark Sarnak , David G Warnock , Mark Woodward , Johan Ärnlöv Background The usefulness of estimated glomerular filtration rate (eGFR) and albumin...
Source: The Lancet Diabetes and Endocrinology - May 30, 2015 Category: Endocrinology Source Type: research

Expert review backs clot busting drug as safe
Review says alteplase is safe and effectiveRelated items from OnMedicaNew technology could determine use of thrombolysis post strokeUsers of HRT at risk of clots and strokeDementia and stroke funding remains too low, say expertsRate of cognitive decline increases for years after strokeTime to rethink 4.5h window for alteplase after stroke
Source: OnMedica Latest News - July 24, 2015 Category: UK Health Source Type: news

Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
Publication date: Available online 17 September 2015 Source:The Lancet Author(s): Andrew Smyth, Koon K Teo, Sumathy Rangarajan, Martin O'Donnell, Xiaohe Zhang, Punam Rana, Darryl P Leong, Gilles Dagenais, Pamela Seron, Annika Rosengren, Aletta E Schutte, Patricio Lopez-Jaramillo, Ayetkin Oguz, Jephat Chifamba, Rafael Diaz, Scott Lear, Alvaro Avezum, Rajesh Kumar, Viswanathan Mohan, Andrzej Szuba, Li Wei, Wang Yang, Bo Jian, Martin McKee, Salim Yusuf Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumpti...
Source: The Lancet - September 18, 2015 Category: Journals (General) Source Type: research

Vittamed pulls in $10m Series A for intracranial pressure device
Vittamed said today it raised $10 million in a Series A round of funding to support its intracranial pressure neurodiagnostic sensor development and launch. The funding round was led by Xeraya Capital Labuan and joined by existing investor Imprimatur Capital and other investors, the Boston-based company said. “The financial support and expertise of Xeraya Capital will help us accelerate Vittamed’s commercial launch. We are excited about our potential to better diagnose and manage patients with many neurological conditions, including traumatic brain injury, hydrocephalus, stroke, and space occupying lesions incl...
Source: Mass Device - October 16, 2015 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Diagnostics Ultrasound Vittamed Source Type: news

Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial
Publication date: Available online 22 October 2015 Source:The Lancet Author(s): Sanjit S Jolly, John A Cairns, Salim Yusuf, Michael J Rokoss, Peggy Gao, Brandi Meeks, Sasko Kedev, Goran Stankovic, Raul Moreno, Anthony Gershlick, Saqib Chowdhary, Shahar Lavi, Kari Niemela, Ivo Bernat, Warren J Cantor, Asim N Cheema, Philippe Gabriel Steg, Robert C Welsh, Tej Sheth, Olivier F Bertrand, Alvaro Avezum, Ravinay Bhindi, Madhu K Natarajan, David Horak, Raymond C M Leung, Saleem Kassam, Sunil V Rao, Magdi El-Omar, Shamir R Mehta, James L Velianou, Samir Pancholy, Vladimír Džavík Background Two ...
Source: The Lancet - October 23, 2015 Category: Journals (General) Source Type: research

Assessing the role of cerebral autoregulation during intrathoracic pressure changes by near infrared spectroscopy (NIRS)
Changes in intrathoracic pressure in obstructive sleep apnea have strong intermittent effects on oxygenation of hemoglobin and left ventricular stroke volume. While compensatory systemic mechanisms are well studied the role of cerebral autoregulation remains essentially unknown. We aimed to compare hemodynamic response in muscle and brain assessed by NIRS during Valsalva- and Müller- maneuvers (VM respectively MM) and thereby describing the role of cerebral autoregulation.In five healthy adults cerebral and muscular NIRS and esophageal pressure (EP) were continuously measured during normal breathing, two VM (EP +15...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Laures, M., Bolz, N., Zhang, Z., Mensen, A., Schmidt, C., Khatami, R. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis
Publication date: Available online 7 November 2015 Source:The Lancet Author(s): Xinfang Xie, Emily Atkins, Jicheng Lv, Alexander Bennett, Bruce Neal, Toshiharu Ninomiya, Mark Woodward, Stephen MacMahon, Fiona Turnbull, Graham S Hillis, John Chalmers, Jonathan Mant, Abdul Salam, Kazem Rahimi, Vlado Perkovic, Anthony Rodgers Background Recent hypertension guidelines have reversed previous recommendations for lower blood pressure targets in high-risk patients, such as those with cardiovascular disease, renal disease, or diabetes. This change represents uncertainty about whether more intensive blood pressure-...
Source: The Lancet - November 9, 2015 Category: Journals (General) Source Type: research

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial
This study is registered with ClinicalTrials.gov, number NCT01425307. Findings Between Sept 20, 2011, and April 17, 2013, 159 patients consented and enrolled in TWiTCH. 121 participants passed screening and were then randomly assigned to treatment (61 to transfusions and 60 to hydroxycarbamide). At the first scheduled interim analysis, non-inferiority was shown and the sponsor terminated the study. Final model-based TCD velocities were 143 cm/s (95% CI 140–146) in children who received standard transfusions and 138 cm/s (135–142) in those who received hydroxycarbamide, with a difference of 4·54 (0·10–8·98). Non-i...
Source: The Lancet - December 7, 2015 Category: Journals (General) Source Type: research

Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT01255540. Findings During a median follow-up of 1·53 years of participants recruited between Dec 10, 2010, and Feb 21, 2014, the primary outcome occurred in 93 (40·6%) of 229 patients assigned to the invasive group and 140 (61·4%) of 228 patients assigned to the conservative group (hazard ratio [HR] 0·53 [95% CI 0·41–0·69], p=0·0001). Five patients dropped out of the invasive group and one from the conservative group. HRs for the four components of the primary composite endpoint were 0·52 (0·35–0·76; p=0·0010) for myocardial infarction, 0·19 (0·0...
Source: The Lancet - January 13, 2016 Category: Journals (General) Source Type: research

Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Publication date: Available online 18 March 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Jason H Y Wu, Celine Foote, Juuso Blomster, Tadashi Toyama, Vlado Perkovic, Johan Sundström, Bruce Neal Background In patients with type 2 diabetes, sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to reduce glucose concentrations, blood pressure, and weight, but to increase LDL cholesterol and the incidence of urogenital infections. Protection against cardiovascular events has also been reported, as have possible increased risks of adverse outcomes such as ketoacidosis and bone fracture. We a...
Source: The Lancet Diabetes and Endocrinology - March 19, 2016 Category: Endocrinology Source Type: research

Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial
Publication date: May 2016 Source:The Lancet Neurology, Volume 15, Issue 6 Author(s): Thorsten Steiner, Sven Poli, Martin Griebe, Johannes Hüsing, Jacek Hajda, Anja Freiberger, Martin Bendszus, Julian Bösel, Hanne Christensen, Christian Dohmen, Michael Hennerici, Jennifer Kollmer, Henning Stetefeld, Katja E Wartenberg, Christian Weimar, Werner Hacke, Roland Veltkamp Background Haematoma expansion is a major cause of mortality in intracranial haemorrhage related to vitamin K antagonists (VKA-ICH). Normalisation of the international normalised ratio (INR) is recommended, but optimum haemostatic managemen...
Source: The Lancet Neurology - April 19, 2016 Category: Neurology Source Type: research

10-year trajectories of depressive symptoms and risk of dementia: a population-based study
We examined a cohort of participants who were free from dementia, but had data for depressive symptoms from at least one examination round in 1993–95, 1997–99, or 2002–04. We assessed depressive symptoms with the validated Dutch version of the Center for Epidemiology Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale-Depression. We used these data to identify 11-year trajectories of depressive symptoms by latent class trajectory modelling. We screened participants for dementia at each examination round and followed up participants for 10 years for incident dementia by latent trajectory from the th...
Source: The Lancet Psychiatry - May 12, 2016 Category: Psychiatry Source Type: research