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Total 633 results found since Jan 2013.

Brainomix raises $10m for AI stroke imaging tech
Brainomix said today that it raised nearly $10 million for the e-ASPECTS stroke imaging technology it’s developing using artificial intelligence. The £7 million round was led by Parkwalk Advisors, joined by existing backers Chimera Partners and Oxford University Innovation Fund and the venture arm of pharma giant Boehringer Ingelheim. Oxford, England-based Brainomix said its tech is designed to automate the evaluation of stroke patients using CT scan data and the Alberta Stroke Program Early CT Score method. The funds are earmarked for commercializing e-ASPECT, the company said. “We welcome Boehringer Ingelhe...
Source: Mass Device - April 3, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Diagnostics Funding Roundup Imaging Neurological Boehringer Ingelheim Pharmaceuticals Brainomix Stroke Source Type: news

The High Cost of Stroke and Stroke Cytoprotection Research
AbstractAcute ischemic stroke is inadequately treated in the USA and worldwide due to a lengthy history of neuroprotective drug failures in clinical trials. The majority of victims must endure life-long disabilities that not only affect their livelihood, but also have an enormous societal economic impact. The rapid development of a neuroprotective or cytoprotective compound would allow future stroke victims to receive a treatment to reduce disabilities and further promote recovery of function. This opinion article reviews in detail the enormous costs associated with developing a small molecule to treat stroke, as well as p...
Source: Translational Stroke Research - December 29, 2016 Category: Neurology Source Type: research

Policy View Increasing value and reducing waste in stroke research
Stroke is a major burden to patients and society, and resources spent on stroke research must be used efficiently and produce good value in terms of improvements in human health. However, many instances of poor value from stroke research funding have resulted from the way in which stroke research topics have been chosen and how studies have been designed, conducted, analysed, regulated, managed, disseminated, or reported. A cooperative effort of European stroke researchers aimed to identify sources of inefficiency and waste, recommend approaches to increase value, and highlight examples of best practice in stroke research.
Source: Lancet Neurology - April 12, 2017 Category: Neurology Authors: Eivind Berge, Rustam Al-Shahi Salman, H Bart van der Worp, Christian Stapf, Peter Sandercock, Nikola Sprigg, Malcolm R Macleod, Peter J Kelly, Paul J Nederkoorn, Gary A Ford, European Stroke Organisation Trials Network Committee Tags: Policy View Source Type: research

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical
AbstractThe first annual Stroke Translational Research Advancement Workshop (STRAW), entitled “Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical” was held at the University of Kentucky on October 4–5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of a ctivities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant ...
Source: Translational Stroke Research - April 10, 2018 Category: Neurology Source Type: research

Academic-industry Collaborations in Translational Stroke Research
Abstract Academic-industry collaborations are an emerging format of translational stroke research. Next to classic contract research models, a multitude of collaboration models has been developed, some of which even allowing for multinational or intercontinental research programs. This development has recently been paralleled by first successful attempts to overcome the translational stroke research road block, such as the unprecedented success of novel endovascular approaches or the advent of the multicenter preclinical trial concept. While the first underlines the role of the industry as a major innovation drive...
Source: Translational Stroke Research - June 13, 2016 Category: Neurology Source Type: research

Perfuze raises $3m seed round for Millipede stroke catheter
Perfuze said today that it raised more than $3 million for the Millipede catheter it’s developing to treat ischemic stroke. Although not quite in stealth mode, the Galway, Ireland-based firm is close-mouthed about its technology. CEO Wayne Allen and CTO Liam Mullins (who co-founded Embo Medical before its  in 2015,  $YY acquisition by C.R. Bard in 2015) founded Perfuze last year. The €3 million ($3.4 million) seed round, earmarked for Millipede development, was led by European VC shop Earlybird. MedFocus, Enterprise Ireland and an Irish syndicate of medtech veterans and stroke physicians also participated, Pe...
Source: Mass Device - January 29, 2019 Category: Medical Devices Authors: Brad Perriello Tags: Catheters Featured Funding Roundup Neurological Perfuze Stroke Source Type: news

Cost-saving innovations for acute ischemic stroke and transient ischemic attack
Health care costs continue to rise toward unsustainable levels that will affect our nation's ability to support other key funding priorities for education, military, and infrastructure. Changing the way we deliver health care is critical to mitigating this financial crisis. This review highlights opportunities for redesigning care of acute ischemic stroke and TIA to maintain quality while substantially lowering costs. The recent innovations described are (1) adopting teleneurology networks to improve access to thrombolysis for acute ischemic stroke; (2) improving efficiency of emergency care for acute ischemic stroke; and ...
Source: Nature Clinical Practice - October 13, 2014 Category: Neurology Authors: Tai, W. A., Conley, J., Kalanithi, L. Tags: All Cerebrovascular disease/Stroke, Models of care, Infarction Eye on Practice Source Type: research

Stroke and the noncommunicable diseases: A global burden in need of global advocacy
Catalyzed by advocacy in the early period of the global AIDS crisis, the past decades have witnessed a revolution in global health funding, programs, and outcomes. In 2011, global HIV/AIDS programs received $7.7 billion of development assistance, amounting to 25% of total global health funding. In comparison, all noncommunicable diseases (NCDs) combined received only $377 million or 1.2% of global health funding, 20-fold less than HIV/AIDS funding.1 Taken together, NCDs cause an estimated 66% of yearly global mortality.2 The percentage of estimated total global mortality due to stroke (11.3%), a single NCD, exceeds that of...
Source: Neurology - May 25, 2015 Category: Neurology Authors: Berkowitz, A. L. Tags: Stroke prevention, All Cerebrovascular disease/Stroke GLOBAL PERSPECTIVES Source Type: research

Translational Hurdles in Stroke Recovery Studies
Abstract Emerging understanding of brain plasticity has opened new avenues for the treatment of stroke. The promising preclinical evidence with neuroprotective drugs has not been confirmed in clinical trials, thus nowadays, researchers, pharmaceutical companies, and funding bodies hesitate to initiate these expensive trials with restorative therapies. Since many of the previous failures can be traced to low study quality, a number of guidelines such as STAIR and STEPS were introduced to rectify these shortcomings. However, these guidelines stem from the study design for neuroprotective drugs and one may question w...
Source: Translational Stroke Research - March 22, 2016 Category: Neurology Source Type: research

Transitioning from a single-site pilot project to a state-wide regional telehealth service: The experience from the Victorian Stroke Telemedicine programme.
Abstract Scaling of projects from inception to establishment within the healthcare system is rarely formally reported. The Victorian Stroke Telemedicine (VST) programme provided a very useful opportunity to describe how rural hospitals in Victoria were able to access a network of Melbourne-based neurologists via telemedicine. The VST programme was initially piloted at one site in 2010 and has gradually expanded as a state-wide regional service operating with 16 hospitals in 2017. The aim of this paper is to summarise the factors that facilitated the state-wide transition of the VST programme. A naturalistic case-s...
Source: Rural Remote Health - October 31, 2017 Category: Rural Health Authors: Bagot KL, Cadilhac DA, Kim J, Vu M, Savage M, Bolitho L, Howlett G, Rabl J, Dewey HM, Hand PJ, Denisenko S, Donnan GA, Bladin CF, Victorian Stroke Telemedicine Programme Consortium Tags: J Telemed Telecare Source Type: research

Post-stroke Sexual Dysfunction in Men: Epidemiology, Diagnostic Work-up, and Treatment
by Rocco Salvatore Calabrò, MD, PhD  Dr. Calabrò is with IRCCS Centro Neurolesi “Bonino-Pulejo” in Messina, Italy. Funding: No funding was provided for this article. Disclosures: The author has no conflicts of interest relevant to the content of this article. Innov Clin Neurosci. 2022;19(7–9):12–16. Abstract Stroke is a leading cause of death and disability throughout […] The post Post-stroke Sexual Dysfunction in Men: Epidemiology, Diagnostic Work-up, and Treatment appeared first on Innovations in Clinical Neuroscience.
Source: Innovations in Clinical Neuroscience - July 1, 2022 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Neurology counseling sexual coach sexuality stroke Source Type: research

Stroke Research in China over the Past Decade: Analysis of NSFC Funding
Abstract We analyzed the projects and published studies funded by NSFC (National Natural Science Foundation of China) in the field of stoke. Further more, we searched the published papers supported by NSFC in the last decade using the keywords of "stroke" or "cerebrovascular disease" and analyzed the results according to the topics associated with the mechanisms of ischemic brain injury, novel techniques and new drugs, medical imaging, translational medicine, and traditional Chinese medicine.
Source: Translational Stroke Research - June 4, 2015 Category: Neurology Source Type: research

Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines
Abstract The multicenter phase III preclinical trial concept is currently discussed to enhance the predictive value of preclinical stroke research. After public announcement, we collected a community feedback on the concept with emphasis on potential design features and guidelines by an anonymous survey. Response analysis was conducted after plausibility checks by applying qualitative and quantitative measures. Most respondents supported the concept, including the implementation of a centralized steering committee. Based on received feedback, we suggest careful, stepwise implementation and to leave selected compet...
Source: Translational Stroke Research - June 13, 2016 Category: Neurology Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research