Expert review backs clot busting drug as safe

Review says alteplase is safe and effectiveRelated items from OnMedicaNew technology could determine use of thrombolysis post strokeUsers of HRT at risk of clots and strokeDementia and stroke funding remains too low, say expertsRate of cognitive decline increases for years after strokeTime to rethink 4.5h window for alteplase after stroke
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Study Objectives:To evaluate continuous positive airway pressure (CPAP) treatment in patients with moderate to severe sleep-disordered breathing (SDB) after an ischemic stroke.Methods:We identified patients included in the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) who underwent polysomnography after an ischemic stroke. We compared patients without significant SDB (apnea-hypopnea index [AHI]
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Study Objectives:We aimed to elucidate the prevalence of sleep-disordered breathing (SDB), effect of SDB severity on the functional outcome, and feasibility of continuous positive airway pressure (CPAP) therapy in patients with subacute stroke.Methods:We recruited 433 consecutive patients (mean age: 66.5 years, 271 men) admitted to our rehabilitation wards for subacute stroke (8 to 90 days after onset) from August 2011–November 2013, who had undergone at least one successful sleep study within 4 weeks after admission to the wards. We investigated the prevalence of SDB, defined as a respiratory event index (REI)≥ 5...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
AbstractDysfunction of energy metabolism exerts a central role in triggering neuron death following cerebral ischemia. Neuronal energy metabolism is highly dependent on glucose. O-GlcNAcylation, a post-translational modification, is a novel pro-survival pathway that modulates glucose homeostasis in ischemic stroke. Here, we explored whether activation O-GlcNAcylation and maintaining energy homeostasis mediated the neuroprotective effect of 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy- β-d-pyranoside, a synthetic salidroside analog (named SalA-4  g) which was previously developed in our laboratory. For in vivo ana...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Conditions:   Stroke, Ischemic;   Stroke Hemorrhagic;   Stroke;   Hemiparesis;   Cerebral Vascular Accident Intervention:   Device: Keeogo™ Dermoskeleton Sponsor:   B-Temia, Inc. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Hand Function Intervention:   Device: ReIn-Hand device assisted home-based practice Sponsor:   Northwestern University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Stroke Intervention:   Behavioral: Home Telerehabilitation using HoVRS Sponsors:   Rutgers, The State University of New Jersey;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   New Jersey Institute of Technology Not yet recruiting
Source: - Category: Research Source Type: clinical trials
In this study, we investigated the function of the lncRNA Oprm1 in cerebral I/R injury and explored the underlying mechanism. An oxygen-glucose deprivation model in N2a cells was utilized to mimic cerebral I/R injury in vitro. Trypan blue staining, terminal deoxytransferase-mediated dUTP-biotin nick end labelling and caspase-3 were measured to evaluate apoptosis. Middle cerebral artery occlusion was performed in mice to evaluate the function of lncRNA Oprm1 in vivo. Real-time PCR and western blotting were used to measure the expression levels of lncRNA Opmr1, caspase-3, miR-155, GATA binding protein 3 (GATA3) and nuclear f...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Researchers at Florida Atlantic University have developed a microfluidic chip that can rapidly assess blood samples from sickle cell disease patients to help monitor the disease. The technique is much faster and more convenient than traditional optic...
Source: Medgadget - Category: Medical Devices Authors: Tags: Diagnostics Medicine Source Type: blogs
Ronnie Kerman, of Bransholme, was found lifeless in his cot in March 2018 by his father. He is receiving chemotherapy for a brain tumour which caused the stroke and left him unable to use his legs.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Struß N, Bauersachs J, Welte T, Hohlfeld JM Abstract Chronic obstructive pulmonary disease (COPD) primarily affects the lungs; however, cardiovascular conditions are among the most common extrapulmonary comorbidities. Besides shared risk factors such as cigarette smoking, pathophysiological connections between the lung and the heart have been identified as mediators of reduced cardiac output. Recent research has focused on hyperinflation of the lung as a pulmonary cause for heart dysfunction. Hyperinflation is a typical lung abnormality seen in COPD; it is characterized by increased residua...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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