Filtered By:
Management: National Institute for Health Research (NIHR)

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 94 results found since Jan 2013.

Dementia rates dropping
Conclusion This study suggests that the prevalence of dementia in over 65s in 2011 is lower than would have been expected.  The study had many strengths, including the large number of people it interviewed from different areas and the consistent research methods adopted in 1991 and again in 2011, particularly using the same criteria to diagnose dementia at both time points. This means we can be relatively sure that its conclusions are reliable. That said, it does have some limitations to consider. The response rate in 2011 (56%) was much lower than in 1991 (80%). The study authors offer a number of explanations for this...
Source: NHS News Feed - July 17, 2013 Category: Consumer Health News Tags: Neurology Older people Medical practice Source Type: news

Assessing the cost‐effectiveness of Type 1 diabetes interventions: the Sheffield Type 1 Diabetes Policy Model
ConclusionsThe model is highly flexible and has broad potential application to evaluate the Dose Adjustment for Normal Eating research programme, other structured diabetes education programmes and other interventions for Type 1 diabetes.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - December 3, 2013 Category: Endocrinology Authors: P. Thokala, J. Kruger, A. Brennan, H. Basarir, A. Duenas, A. Pandor, M. Gillett, J. Elliott, S. Heller Tags: Research Article Source Type: research

4-Year Follow-up of Delayed-Release Dimethyl Fumarate Treatment in Relapsing-Remitting Multiple Sclerosis (RRMS): Integrated Magnetic Resonance Imaging (MRI) Outcomes From DEFINE, CONFIRM, and the ENDORSE Extension Study (P3.160)
CONCLUSIONS: Reduced frequency of new MRI lesions is maintained over 4 years among patients continuing therapy. Switching from placebo to delayed-release DMF, patients demonstrated MRI outcomes similar to those with delayed-release DMF in DEFINE/CONFIRM. Together with clinical efficacy and an acceptable safety profile, results support delayed-release DMF as a potential long-term treatment option for relapsing MS.Study Supported by: Biogen IdecDisclosure: Dr. Arnold has received personal compensation for activities with Acorda Therapeutics, Bayer Pharmaceuticals Corporation, Biogen Idec, Coronado Biosciences, EMD Serono, Ge...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Arnold, D., Fox, R., Gold, R., Havrdova, E., Kappos, L., Yousry, T., Zhang, R., Yang, M., Viglietta, V., Sheikh, S., Miller, D. Tags: MS and CNS Inflammatory Disease: Clinical Trials Outcomes Source Type: research

Phenotypic Differences In The Distribution Of Gray Matter Lesions In Multiple Sclerosis And Their Relevance To Cognition (P5.013)
CONCLUSIONS:There is a fronto-temporal dominance and occipital paucity, of cortical lesions. Cognitive deficits commonly ascribed to frontal and temporal lobe functions are associated with cortical or juxtacortical lesion load in the corresponding lobe independent of any effect of white matter lesion load.Study Supported by:MS Society of Great Britain and Northern Ireland, and the UCLH Comprehensive Biomedical Research Centre.Disclosure: Dr. Sethi has received personal compensation for activities with Biogen Idec and Novartis. Dr. Sethi has received research support from the Multiple Sclerosis Society of Great Britain and ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sethi, V., Yousry, T., Muhlert, N., Tozer, D., Altmann, D., Ron, M., Wheeler-Kingshott, C., Miller, D., Chard, D. Tags: MS and CNS Inflammatory Disease II Source Type: research

Accrual And Evolution Of Cortical Gray Matter Lesions In People With Relapse-Onset Multiple Sclerosis (P6.133)
CONCLUSIONS:People with SPMS have a significantly greater accrual of cortical demyelination than those with RRMS. In both clinical subgrops, a minority of IC lesions become LC at follow-up. A higher IC-CGM lesion load and accumulation appears to be a feature of SPMSStudy Supported by: MS Society of Great Britain and Northern Ireland, and the UCLH Comprehensive Biomedical Research Centre.Disclosure: Dr. Sethi has received personal compensation for activities with Biogen Idec and Novartis. Dr. Sethi has received research support from the Multiple Sclerosis Society of Great Britain and Northern Ireland. Dr. Yousry has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sethi, V., Yousry, T., Muhlert, N., Tozer, D., Altmann, D., Ron, M., Wheeler-Kingshott, C., Miller, D., Chard, D. Tags: MS and CNS Inflammatory Disease: Neuroimaging Source Type: research

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people
This study is registered at ClinicalTrials.gov (NCT01804439). Findings Our cohort consisted of 1 921 260 individuals, of whom 1 887 062 (98·2%) did not have diabetes and 34 198 (1·8%) had type 2 diabetes. We observed 113 638 first presentations of cardiovascular disease during a median follow-up of 5·5 years (IQR 2·1–10·1). Of people with type 2 diabetes, 6137 (17·9%) had a first cardiovascular presentation, the most common of which were peripheral arterial disease (reported in 992 [16·2%] of 6137 patients) and heart failure (866 [14·1%] of 6137 patients). Type 2 diabetes was positively associated wi...
Source: The Lancet Diabetes and Endocrinology - December 5, 2014 Category: Endocrinology Source Type: research

The BRACELET study: implications for the design of randomised controlled trials in neonatal and paediatric intensive care
Research is essential to improving care and outcomes, but presents challenges when infants and children are the patients. Over the last few years, several thousand infants and children receiving intensive care have joined randomised controlled trials (RCT) in the UK, the majority of those conducted under the auspices of the National Institute for Health Research (NIHR) portfolio. Globally, tens of thousands of children and infants take part in RCTs. When those children survive, many continue to partake in studies with involvement over several years and potentially into adulthood. That is essential; in no other branch of me...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 18, 2015 Category: Perinatology & Neonatology Authors: Embleton, N. D., Rankin, J. Tags: Clinical trials (epidemiology), Stroke, Pregnancy, Reproductive medicine, Child health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care, Paediatric intensive care Editorials Source Type: research

The ms-smart trial in secondary progressive multiple sclerosis: a multi-arm, multi-centre trial of neuroprotection
There is currently no treatment for secondary progressive multiple sclerosis (SPMS) which determines the majority of disability in multiple sclerosis. The MS-SMART trial is a multi-arm, multi-centre, phase 2 randomised trial for patients with SPMS. A total of 440 patients with progressing SPMS will be recruited in England and Scotland and randomised to one of 4 blinded arms: amiloride 5mg bd, riluzole 50mg bd, fluoxetine 20mg bd or placebo. These agents have been chosen after an extensive systematic review which has suggested putative neuroprotective properties. Patients will be followed up for 96 weeks with outcome data c...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2015 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Giovannoni, G., Wheeler-Kingshott, C., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., for the MS-SMART trialists Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) Thur 21, Parallel session 5: Therapeutics Source Type: research

No significant benefit found in new treatment method for coronary artery bypass surgery
A study looking at ways to reduce damage to heart muscle during coronary artery bypass graft surgery (CABG) found using remote ischaemic preconditioning (RIPC) treatment did not provide greater protection against events including stroke, heart attack and cardiovascular death.RIPC is a virtually cost free, non-pharmacological and non-invasive treatment. The process involves using a blood pressure...
Source: NIHR Evaluation, Trials and Studies News - October 15, 2015 Category: American Health Source Type: news

An Occupational Therapy intervention for residents with stroke-related disabilities in UK Care Homes (OTCH): cluster randomised controlled trial with economic evaluation, Health Technology Assessment, Vol:20, Iss:15
Authors: Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, Fletcher-Smith J, Steel K, Barton GR, Irvine L, Peryer G.
Source: NIHR Journals Library - March 1, 2016 Category: Global & Universal Source Type: research

The ms-smart trial in secondary progressive ms - current update
MS-SMART is an ongoing multicentre, multi-arm, double blind, placebo-controlled phase IIb randomised controlled trial to establish whether putative neuroprotective drugs (fluoxetine,riluzole,amiloride or placebo) can slow down the progression of brain volume loss in secondary progressive multiple sclerosis (SPMS) over 96 weeks using MRI-derived Percentage Brain Volume Change (PBVC) as the primary outcome. 360 patients have been screened so far, 328 (92%) consented and 272 randomized (65% of the total UK cohort–440). Patients will have outcome-data collected after 0,24,48 and 96 weeks. The trial is using a range of co...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Connick, P., Giovannoni, G., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., Plantone, D. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Research tackles major cause of death following stroke
Source: HTA - NIHR Evaluation, Trials and Studies - November 22, 2016 Category: UK Health Source Type: news

Handful of nuts 'cuts heart disease and cancer' risk
Conclusions This systematic review finds evidence that nut intake may be linked with reduced risk of cardiovascular disease, cancer and death. The systematic review has several strengths. It identified a large number of studies with a large total sample size. It also included only prospective cohorts assessing nut consumption and then followed up later disease outcomes. It excluded cross sectional studies, which assess diet and disease at the same time, and so can't show the direction of effect. It also excluded cohorts that have retrospectively questioned diet when the person already has the disease, which could be subjec...
Source: NHS News Feed - December 5, 2016 Category: Consumer Health News Tags: Food/diet Cancer Heart/lungs Source Type: news

Weekend-only workouts 'still give an important health boost'
Conclusion This survey aimed to investigate patterns of physical activity in adults over the age of 40 and the potential impact on their cause of death. The study found that, compared with those who were not physically active, all active groups saw a reduction in their risk of death from any cause and cardiovascular disease. Being active at the weekend only had no effect on cancer mortality. However, interpretations around the optimal level of activity are difficult when you note that insufficient activity gave similar mortality reductions as the recommended regular activity. This study has both strengths and limitations...
Source: NHS News Feed - January 10, 2017 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Cancer Source Type: news

NIHR Signal: Better prescribing might prevent thousands of strokes in the UK
Expert commentary is provided of a study which found that based on data from almost 30000 people who had a stroke, 60% had risk factors that meant they may have been eligible to take cholesterol-lowering, antiplatelet or BP medication, but 54% had no recent prescription for these
Source: Current Awareness Service for Health (CASH) - May 9, 2017 Category: Consumer Health News Source Type: news