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Total 94 results found since Jan 2013.

Flu jab "may cut" stroke risk by a quarter
ConclusionThis research finds that, overall, having the flu vaccine reduced the risk of a person experiencing a stroke by about 25%. The reduction in risk seemed to be greatest within the first three months of vaccination, but remained for up to 12 months.  However, the effect lasted only if the vaccine was given early in the flu season (September to mid-November); giving the vaccine late in the flu season (mid-November to February) was not associated with significantly reduced risk.The research benefits from using data coded within the General Practice Research Database for England and Wales for almost 50,000 people with...
Source: NHS News Feed - February 21, 2014 Category: Consumer Health News Tags: Heart/lungs Neurology Older people Source Type: news

GP receptionists 'could help prevent stroke deaths'
Conclusion This valuable and well-designed study assessed a cross-section of general practices from one UK region, looking at how well receptionists are able to recognise the signs of stroke and give appropriate advice – either immediately passing patients on to the GP or telling them to contact emergency services. The study has many strengths. These include the large sample of GP surgeries and calls assessed, and that receptionists weren't aware of the nature of the study and the calls were unannounced. At the end of each individual call receptionists were told the call was part of the study and no further action was n...
Source: NHS News Feed - June 29, 2015 Category: Consumer Health News Tags: Medical practice Neurology Source Type: news

Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Publication date: Available online 18 May 2016 Source:The Lancet Author(s): Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Background Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical treatment in the acute phase than do longer-term trials. ...
Source: The Lancet - May 19, 2016 Category: Journals (General) Source Type: research

Prophylactic antibiotics after acute stroke for reducing pneumonia in patients with dysphagia (STROKE-INF): a prospective, cluster-randomised, open-label, masked endpoint, controlled clinical trial
This study assessed the effectiveness of antibiotic prophylaxis for reducing pneumonia in patients with dysphagia after acute stroke. Methods We did a prospective, multicentre, cluster-randomised, open-label controlled trial with masked endpoint assessment of patients older than 18 years with dysphagia after new stroke recruited from 48 stroke units in the UK, accredited and included in the UK National Stroke Audit. We excluded patients with contraindications to antibiotics, pre-existing dysphagia, or known infections, or who were not expected to survive beyond 14 days. We randomly assigned the units (1:1) by computer to ...
Source: The Lancet - September 5, 2015 Category: Journals (General) Source Type: research

Time-course of functional recovery after acute ischaemic stroke and its relationship to cause-specific mortality: Implications for follow-up of stroke trials (S19.004)
Conclusions:Functional recovery continues to occur between 3 months and 1 year post-stroke, but disability by 3 months strongly predicts long-term stroke-related death/dependency. By extending follow-up to 1 year, trials can capture most salient differences in long-term disability and index-stroke-related deaths.Study Supported by:The Oxford Vascular Study has been funded by the Wellcome Trust, Wolfson Foundation, UK Stroke Association and the NIHR Oxford Biomedical Research Centre. PMR is in receipt of an NIHR Senior Investigator Award and a Wellcome Trust Senior Investigator Award. AG is funded by the Rhodes Trust.Disclo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ganesh, A., Luengo-Fernandez, R., Wharton, R. M., Gutnikov, S. A., Silver, L. E., Mehta, Z., Rothwell, P. M., on behalf of the Oxford Vascular Study Tags: Best Of: Cerbrovascular Disease and Interventional Neurology Source Type: research

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study
Publication date: March 2019Source: The Lancet Neurology, Volume 18, Issue 3Author(s): Sarah T Pendlebury, Peter M Rothwell, Oxford Vascular StudySummaryBackgroundRisk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke.MethodsThe Oxford Vascular Study is a prospective incidence study of all vascular events in a population of 92 728 people residing in Oxfordshire, UK. Patients with tran...
Source: The Lancet Neurology - February 14, 2019 Category: Neurology Source Type: research

Prevalence of patent foramen ovale in cryptogenic transient ischaemic attack and non-disabling stroke at older ages: a population-based study, systematic review, and meta-analysis
Publication date: Available online 7 June 2018 Source:The Lancet Neurology Author(s): Sara Mazzucco, Linxin Li, Lucy Binney, Peter M Rothwell Background Percutaneous closure of patent foramen ovale (PFO) has been shown to be superior to medical treatment alone for prevention of recurrent stroke after cryptogenic transient ischaemic attack or non-disabling stroke in patients aged 60 years or younger. The justification for trials in older patients with transient ischaemic attack or stroke depends on whether PFO is shown to be associated with cryptogenic events at older ages, for which existing evidence is conflicting, and o...
Source: The Lancet Neurology - June 8, 2018 Category: Neurology Source Type: research

Heart attack, stroke and diabetes 'can shorten life by 23 years'
Conclusion This study used two large cohort-derived data sets to estimate the number of years of life lost as the result of a history of heart attack, stroke or diabetes across different ages. The study's large size, relevance to the UK and long-term follow-up increases our confidence in its conclusions and their relevance to England and Wales. As with all studies, it has limitations, but these were relatively small and unlikely to affect the main conclusions. This study shows a history of stroke, type 2 diabetes and heart attack can significantly shorten life expectancy, especially if these conditions are developed earli...
Source: NHS News Feed - July 8, 2015 Category: Consumer Health News Tags: Heart/lungs Diabetes Lifestyle/exercise Neurology Older people Source Type: news

Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study
Publication date: Available online 27 July 2015 Source:The Lancet Neurology Author(s): Linxin Li, Gabriel S Yiin, Olivia C Geraghty, Ursula G Schulz, Wilhelm Kuker, Ziyah Mehta, Peter M Rothwell Background A third of transient ischaemic attacks (TIAs) and ischaemic strokes are of undetermined cause (ie, cryptogenic), potentially undermining secondary prevention. If these events are due to occult atheroma, the risk-factor profile and coronary prognosis should resemble that of overt large artery events. If they have a cardioembolic cause, the risk of future cardioembolic events should be increased. We aimed to asses...
Source: The Lancet Neurology - July 28, 2015 Category: Neurology Source Type: research

Exploring the experiences of stroke survivors, informal caregivers and healthcare providers in Sierra Leone: a qualitative study protocol
This study has received ethical approval from the Sierra Leone Ethics and Scientific Review Committee (8 December 2020) and the KCL Biomedical & Health Sciences, Dentistry, Medicine and Natural & Mathematical Sciences Research Ethics Subcommittee (reference: HR-20/21-21050). The findings of the study and learning in terms of the process of coproduction and involvement of stroke survivors will be disseminated via peer-reviewed publications, conferences, media and lay reports.
Source: BMJ Open - December 30, 2021 Category: General Medicine Authors: O'Hara, J., Thompson, M., Deen, G., Leather, A. J. M., Youkee, D., Wall, J., Sackley, C., Parmar, D., McKevitt, C., NIHR Global Health Research Group at Kings College London, Wolfe, Langhorne, Lisk, Deen, McKevitt, Watkins, Leather, Prince, Youkee, Wang, Tags: Open access, Qualitative research Source Type: research

Orgranisation and Quality of stroke services
The National Institute for Health Research has published Roads to recovery: organisation and quality of stroke services. This themed review brings together recent evidence relevant to those planning and delivering stroke services, those delivering treatments to people with stroke and to those living with stroke. Together with other evidence, this review may be particularly useful for those developing stroke pathways and care across a system
Source: Current Awareness Service for Health (CASH) - March 28, 2017 Category: Consumer Health News Source Type: news

Organisation and Quality of stroke services
The National Institute for Health Research has published Roads to recovery: organisation and quality of stroke services. This themed review brings together recent evidence relevant to those planning and delivering stroke services, those delivering treatments to people with stroke and to those living with stroke. Together with other evidence, this review may be particularly useful for those developing stroke pathways and care across a system
Source: Current Awareness Service for Health (CASH) - March 28, 2017 Category: Consumer Health News Source Type: news

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
Publication date: Available online 5 December 2018Source: The LancetAuthor(s): Martin Dennis, Gillian Mead, John Forbes, Catriona Graham, Maree Hackett, Graeme J Hankey, Allan House, Stephanie Lewis, Erik Lundström, Peter Sandercock, Karen Innes, Carol Williams, Jonathan Drever, Aileen Mcgrath, Ann Deary, Ruth Fraser, Rosemary Anderson, Pauli Walker, David Perry, Connor McgillSummaryBackgroundResults of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.MethodsFOCUS was a pragmatic, multicentre, parallel group, double-b...
Source: The Lancet - December 5, 2018 Category: General Medicine Source Type: research

Health Economic Evaluations of Digital Health Interventions for Secondary Prevention in Stroke Patients: A Systematic Review
Background: In the first 5 years after their stroke, about a quarter of patients will suffer from a recurrent stroke. Digital health interventions facilitating interactions between a caregiver and a patient from a distance are a promising approach to improve patient adherence to lifestyle changes proposed by secondary prevention guidelines. Many of these interventions are not implemented in daily practice, even though efficacy has been shown. One of the reasons can be the lack of clear economic incentives for implementation. We propose to map all health economic evidence regarding digital health interventions for secondary...
Source: Cerebrovascular Diseases Extra - January 13, 2019 Category: Neurology Source Type: research

New study in stroke therapy investigates 160,000 patients’ records
A study funded by the HS&DR Programme, will investigate 160,000 recently available patient records to identify issues affecting the quality of stroke therapy in England. Around 1.2 million people in the UK are classed as stroke survivors with around 150,000 new incidences of stroke each year. Although three quarters of people survive their stroke, many...
Source: NIHR Evaluation, Trials and Studies News - February 2, 2016 Category: American Health Source Type: news