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Management: National Institute for Health Research (NIHR)
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Total 94 results found since Jan 2013.
The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes
The English National Institute for Health Research Clinical Research Network first established Hyperacute Stroke Research Centres (HSRCs) in 2010 to support multicentre hyperacute (
Source: Health Research Policy and Systems - February 13, 2019 Category: International Medicine & Public Health Authors: Thompson G. Robinson, Xia Wang, Alice C. Durham, Gary A. Ford, Joy Liao, Sine Littlewood, Christine Roffe, Philip White, John Chalmers and Craig S. Anderson Tags: Research Source Type: research
Statins side effects are minimal, study argues
ConclusionThis meta-analysis pooled results from 29 studies and has shown a very small increased risk of newly diagnosed diabetes mellitus. This is the same as the decreased risk of any cause of death in people taking statins, compared to placebo, to prevent a heart attack or stroke.The researchers point out some limitations to the meta-analysis: Each study did not report on all of the side effects, meaning that for each category of side effect, the number of participants differed. The side effect categories were only included if at least 500 people had reported suffering from it. This means there may be numerous other si...
Source: NHS News Feed - March 13, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news
Risk of aspirin-related bleeding is higher in the over-75s
Conclusion
This valuable cohort study helps to quantify the extent of bleeding risk in people taking aspirin for secondary prevention of cardiovascular disease.
Aspirin is well known to carry bleeding risk – particularly in older adults – but this study suggests the risk may be higher than previously thought. The researchers say that for adults under the age of 75, the annual bleeding risk at around 1% is similar to that suggested by previous trials, as is the ratio of bleeds to the number of cardiovascular events. However, this risk increases for older adults, especially for major bleeds of the stomach and upper diges...
Source: NHS News Feed - June 14, 2017 Category: Consumer Health News Tags: Medication Older people Source Type: news
Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis
Publication date: Available online 3 September 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Natriuretic Peptides Studies Collaboration Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In this individual-participant-data meta-analysis, we generated and harmoni...
Source: The Lancet Diabetes and Endocrinology - September 2, 2016 Category: Endocrinology Source Type: research
Following UK dietary advice may cut heart disease risk
Conclusion
This study showed that following dietary recommendations closely for 12 weeks can reduce blood pressure by a significant amount, which is likely to cut the chances of having a heart attack or stroke for an average healthy middle-aged person. The diet also affects cholesterol levels, but the overall effect of this may be modest.
The study appears to have been carefully conducted to avoid biasing the results. The researchers gave butter or margarine spread and cooking oil to people in both groups, for example, and asked everyone to fill out food diaries, as well as taking urine samples for nutrient analysis.
Thi...
Source: NHS News Feed - March 19, 2015 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news
Moderate drinking may reduce heart disease risk
Conclusion
This study paints a more complicated picture than the "Pint a day keeps the doctor away" story proffered by The Sun.
It seems to confirm the findings of other studies, which have shown that non-drinkers tend to have a higher risk of cardiovascular diseases than people who drink moderately.
It suggests that some cardiovascular diseases (mainly those directly affecting the heart) seem to have a stronger link to a possible protective effect from alcohol than other vascular diseases, such as mini-strokes and bleeding in the brain. However, this can't be concluded with certainty due to the study design.
We ...
Source: NHS News Feed - March 23, 2017 Category: Consumer Health News Tags: Heart/lungs Food/diet Lifestyle/exercise Source Type: news
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
Publication date: Available online 24 December 2015 Source:The Lancet Author(s): Dena Ettehad, Connor A Emdin, Amit Kiran, Simon G Anderson, Thomas Callender, Jonathan Emberson, John Chalmers, Anthony Rodgers, Kazem Rahimi Background The benefits of blood pressure lowering treatment for prevention of cardiovascular disease are well established. However, the extent to which these effects differ by baseline blood pressure, presence of comorbidities, or drug class is less clear. We therefore performed a systematic review and meta-analysis to clarify these differences. Method For this systematic review and meta-ana...
Source: The Lancet - December 25, 2015 Category: Journals (General) Source Type: research
Walking reduces heart disease in people at risk
Conclusion
This study of adults at high risk of type 2 diabetes and heart disease has found that every 2,000 steps they normally took each day was associated with a 10% lower risk of a cardiovascular event. And 12 months later, each extra 2,000 steps per day people did beyond their original number of steps was associated with an additional 8% difference in the cardiovascular event rate.
This large study recruited participants from around the world and the researchers adjusted for a number of potential confounders.
However, the study had a number of limitations, including:
A large amount of information on the number of s...
Source: NHS News Feed - December 23, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Source Type: news
Overweight diabetics 'live longer' than slimmer diabetics
Conclusion
This large prospective cohort following over 10,000 older adults with type 2 diabetes for 10 years has found that while being overweight or obese is linked to increased risk of cardiovascular events, being overweight is linked to reduced risk of death. This is similar to the "obesity paradox" seen in some other studies, where being overweight or obese is associated with a survival benefit in people with established cardiovascular disease.
The researchers note that 16 other studies have assessed the same question and found conflicting results. Their study aimed to improve on the methods in these studies...
Source: NHS News Feed - May 11, 2015 Category: Consumer Health News Tags: Diabetes Food/diet Obesity Source Type: news
Implementing major system change in healthcare
Research funded by the NIHR HS&DR Programme is looking into how changes in the delivery and organisation of stroke care are implemented to help inform future changes. The National Stroke Strategy for England, launched in 2007, aimed to improve the care of stroke patients around the UK, by addressing the variations across the country in...
Source: NIHR Evaluation, Trials and Studies News - June 10, 2016 Category: American Health Source Type: news
Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials
Professor Tom Robinson is Head of the Department of Cardiovascular Sciences at the University of Leicester, National Specialty Lead for the National Institute for Health Research Clinical Research Network, and President of the British Association of Stroke Physicians. Professor Robinson works as a Stroke Physician, and his research focus is on clinical trials in acute stroke, particularly blood pressure and thrombolysis management, and studies of cardiovascular and cerebrovascular regulatory mechanisms.
Source: Cardiovascular Research - March 24, 2018 Category: Cardiology Source Type: research
2019 Cochrane-REWARD Prize winners announced
We are pleased to announce the winners – one first place and two runners-up – of this year’s Cochrane-REWARD Prize. The Cochrane-REWARD Prize recognizes successful local or pilot initiatives that have potential to reduce research waste globally if scaled up. Cochrane has funded the prize annually since it began in 2017.The prize ceremony took place on Wednesday 9 October at the International Clinical Trials Methodology Conference in Brighton, UK. Dr Joan Marsh, Deputy Editor of The Lancet Psychiatry and member of the prize committee, was there to hand out the prizes. During the conference, each recipient also had the...
Source: Cochrane News and Events - October 18, 2019 Category: Information Technology Authors: Lydia Parsonson Source Type: news
Lack of vitamin D may 'raise dementia risk'
Conclusion
This cohort study of more than 1,650 elderly people has found that over 5.6 years, severe vitamin D deficiency is associated with approximately twice the risk of developing dementia or Alzheimer's disease.
It also found moderate deficiency is associated with a 50% increase in risk compared with healthy levels of vitamin D.
With this being a cohort study, it was not able to show that low levels of vitamin D caused dementia or Alzheimer's disease – it was simply able to show an association.
Other factors that can increase the risk of developing dementia, such as a poor diet, lack of activity and general poor h...
Source: NHS News Feed - August 7, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Older people Neurology Mental health Source Type: news
Development and evaluation of tools and an intervention to improve patient- and carer-centred outcomes in Longer-Term Stroke care and exploration of adjustment post stroke: the LoTS care research programme, Programme Grants for Applied Research, Vol:2, Iss:6
Authors: Forster A, Mellish K, Farrin A, Bhakta B, House A, Hewison J, Murray J, Patel A, Knapp M, Breen R, Chapman K, Holloway I, Hawkins R, Shannon R, Nixon
Source: NIHR Journals Library - December 25, 2014 Category: Global & Universal Source Type: research
