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Source: Experimental Brain Research

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Total 199 results found since Jan 2013.

Evidence for a role of the reticulospinal system in recovery of skilled reaching after cortical stroke: initial results from a model of ischemic cortical injury.
Abstract The purposes of this pilot study were to create a model of focal cortical ischemia in Macaca fascicularis and to explore contributions of the reticulospinal system in recovery of reaching. Endothelin-1 was used to create a focal lesion in the shoulder/elbow representation of left primary motor cortex (M1) of two adult female macaques. Repetitive microstimulation was used to map upper limb motor outputs from right and left cortical motor areas and from the pontomedullary reticular formation (PMRF). In subject 1 with a small lesion and spontaneous recovery, reaching was mildly impaired. Changes were evident...
Source: Experimental Brain Research - August 1, 2015 Category: Neuroscience Authors: Herbert WJ, Powell K, Buford JA Tags: Exp Brain Res Source Type: research

Correction to: Coordination of muscles to control the footpath during over-ground walking in neurologically intact individuals and stroke survivors.
Abstract In the original publication of the article, the corrections for the typographical errors in the equations for variance that affects the footpath (VORT) and the total variance (VTOT) should be as following. PMID: 29574479 [PubMed - as supplied by publisher]
Source: Experimental Brain Research - March 24, 2018 Category: Neuroscience Authors: Srivastava S, Kao PC, Reisman DS, Higginson JS, Scholz JP Tags: Exp Brain Res Source Type: research

"1.5 Dissociation" of somatoparaphrenia for the upper limb and neglect for the lower limb following a thalamic stroke presenting as flaccid hemiparesis: rehabilitation applications and neuroscience implications.
Abstract PMID: 30386881 [PubMed - as supplied by publisher]
Source: Experimental Brain Research - November 2, 2018 Category: Neuroscience Authors: Randev S, Quiroga O, Islam M, Altschuler EL Tags: Exp Brain Res Source Type: research

Reply to: "1.5 Dissociation" of somatoparaphrenia for the upper limb and neglect for the lower limb following a thalamic stroke presenting as flaccid hemiparesis: rehabilitation applications and neuroscience implications.
Abstract PMID: 30680423 [PubMed - as supplied by publisher]
Source: Experimental Brain Research - January 25, 2019 Category: Neuroscience Authors: Perren F, Blanke O, Landis T Tags: Exp Brain Res Source Type: research

Speech apraxia and oral apraxia: association or dissociation? A multivariate lesion-symptom mapping study in acute stroke patients
Exp Brain Res. 2021 Oct 15. doi: 10.1007/s00221-021-06224-3. Online ahead of print.ABSTRACTThe anatomical relationship between speech apraxia (SA) and oral apraxia (OA) is still unclear. To shed light on this matter we studied 137 patients with acute ischaemic left-hemisphere stroke and performed support vector regression-based, multivariate lesion-symptom mapping. Thirty-three patients presented with either SA or OA. These two symptoms mostly co-occurred (n = 28), except for few patients with isolated SA (n = 2) or OA (n = 3). All patient with either SA or OA presented with aphasia (p < 0.001) and these symptoms were h...
Source: Experimental Brain Research - October 15, 2021 Category: Neuroscience Authors: Martina Conterno Dorothee K ümmerer Andrea Dressing Volkmar Glauche Horst Urbach Cornelius Weiller Michel Rijntjes Source Type: research

Can prior exposure to repeated non-paretic slips improve reactive responses on novel paretic slips among people with chronic stroke?
This study examined if people with chronic stroke (PwCS) could adapt following non-paretic overground gait-slips and whether such prior exposure to non-paretic slips could improve reactive responses on novel paretic slip. Forty-nine PwCS were randomly assigned to either adaptation group, which received eight unexpected, overground, nonparetic-side gait-slips followed by two paretic-side slips or a control group, which received two paretic-side slips. Slip outcome, recovery strategies, center of mass (CoM) state stability, post-slip stride length and slipping kinematics were analyzed. The adaptation group demonstrated fall-...
Source: Experimental Brain Research - February 2, 2022 Category: Neuroscience Authors: Shamali Dusane Tanvi Bhatt Source Type: research

Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1
Exp Brain Res. 2022 Dec 23. doi: 10.1007/s00221-022-06519-z. Online ahead of print.ABSTRACTWe aim to research the molecular mechanism of lncRNA NEAT1 in the activation of astrocytes in a cerebral ischemia-reperfusion injury model. Mouse model of cerebral ischemia-reperfusion injury was constructed, and shNEAT1 was transfected. The infarct area, brain water content, and neurological deficiency were detected. Immunofluorescence detection and fluorescence in situ hybridization (FISH) assay were processed to detect glial fibrillary acidic protein (GFAP) expression. Astrocyte cells were cultured for oxygen-glucose deprivation/r...
Source: Experimental Brain Research - December 23, 2022 Category: Neuroscience Authors: Haijian Zheng Gai Zhang Guanglan Liu Ling Wang Source Type: research

Thiolutin attenuates ischemic stroke injury via inhibition of NLRP3 inflammasome: an in vitro and in vivo study
Exp Brain Res. 2023 Feb 7. doi: 10.1007/s00221-023-06566-0. Online ahead of print.ABSTRACTA recent study confirmed that thiolutin is effective in the treatment of nucleotide-binding domain-like receptor protein 3 (NLRP3)-related inflammatory diseases. Nevertheless, whether thiolutin (THL) is involved in the regulation of NLRP3 inflammasome in ischemic stroke is not known. The murine neuronal cell oxygen-glucose deprivation (OGD) model was first established, and then different concentrations (25 nM and 50 nM) of THL were administered for 48 h incubation, respectively. Subsequently, cell viability and toxicity, and the level...
Source: Experimental Brain Research - February 7, 2023 Category: Neuroscience Authors: Yujie Jia Kun Xue Ying Luo Chang Liu Source Type: research

Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1 α
In this study, using the middle cerebral artery occlusion (MCAO) model of mice, we evaluated the temporal and spatial effects of A1 receptor after ischemic stroke and verified the neuroprotection of A1 receptor. Neurological scores were used to assess functional changes in mice. At the same time, we observed the effect of activating A1 receptor on MB and PGC-1α, and the effect of knockdown PGC-1α on A1 receptor induced MB in vitro. WB and immunofluorescence were used to detect relevant indicators of MB. In addition, we downregulated PGC-1α in vivo to observe the effects on A1 receptor induced MB and neuroprotection. The...
Source: Experimental Brain Research - April 20, 2023 Category: Neuroscience Authors: Wei Han Erfei Zhang Yiyuan Tian Shiquan Wang Yahui Chen Source Type: research

Preferred directions of arm movements are independent of visual perception of spatial directions.
Abstract Directional preferences have previously been demonstrated during horizontal arm movements. These preferences were characterized by a tendency to exploit interaction torques for movement production at the shoulder or elbow, indicating that the preferred directions depend on biomechanical, and not on visual perception-based factors. We directly tested this hypothesis by systematically dissociating visual information from arm biomechanics. Sixteen subjects performed a free-stroke drawing task that required performance of fast strokes from the circle center toward the perimeter, while selecting stroke directi...
Source: Experimental Brain Research - November 21, 2013 Category: Neuroscience Authors: Dounskaia N, Wang W, Sainburg RL, Przybyla A Tags: Exp Brain Res Source Type: research