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Source: Experimental Brain Research

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Total 199 results found since Jan 2013.

Enhanced error facilitates motor learning in weight shift and increases use of the paretic leg during walking at chronic stage after stroke
In conclusion, applying pelvis resistance forces to increase error signals may facilitate motor learning of weight shift toward the paretic side and enhance use of the paretic leg in chronic stroke survivors. Results from this study may be utilized to develop an intervention approach to improve walking in stroke survivors.PMID:34477919 | DOI:10.1007/s00221-021-06202-9
Source: Experimental Brain Research - September 3, 2021 Category: Neuroscience Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research

Bimanual coordination during reach-to-grasp actions is sensitive to task goal with distinctions between left- and right-hemispheric stroke
Exp Brain Res. 2022 Jul 23. doi: 10.1007/s00221-022-06419-2. Online ahead of print.ABSTRACTThe perceptual feature of a task such as how a task goal is perceived influences performance and coordination of bimanual actions in neurotypical adults. To assess how bimanual task goal modifies paretic and non-paretic arm performance and bimanual coordination in individuals with stroke affecting left and right hemispheres, 30 participants with hemispheric stroke (15 right-hemisphere damage-RHD); 15 left-hemisphere damage-LHD) and 10 age-matched controls performed reach-to-grasp and pick-up actions under bimanual common-goal (i.e., ...
Source: Experimental Brain Research - July 23, 2022 Category: Neuroscience Authors: Tessa Johnson Gordon Ridgeway Dustin Luchmee Joshua Jacob Shailesh Kantak Source Type: research

Exercise intensity modulates the change in cerebral blood flow following aerobic exercise in chronic stroke.
This study investigated how cycling intensity and aerobic fitness influence cerebral blood flow (CBF) following a single exercise session. Thirteen community-living stroke survivors performed 20 min of semi-recumbent cycling at low and moderate intensities (40-50 and 60-70 % of heart rate reserve, respectively) as determined from an exercise stress test. CBF was quantified by arterial spin labeling MRI at baseline, as well as 30 and 50 min post-exercise. An intensity-dependent effect was observed in the right post-central and supramarginal gyri up to 50 min after exercise (uncorrected p < 0.005, cluster size ≥10...
Source: Experimental Brain Research - May 24, 2015 Category: Neuroscience Authors: Robertson AD, Crane DE, Rajab AS, Swardfager W, Marzolini S, Shirzadi Z, Middleton LE, MacIntosh BJ Tags: Exp Brain Res Source Type: research

Relationship of diminished interjoint coordination after stroke to hand path consistency.
Abstract Differences between 12 left-brain (LCVA, 65.4 ± 11.7 years old) and 10 right-brain (RCVA, 61 ± 12.1 years old) chronic stroke survivors and 10 age-matched control adults in coordinating specific joint motions of the arm to stabilize hand path when reaching to a central target were investigated in this study. The importance of coordinating joints to stabilize hand path was tested by comparing results from uncontrolled manifold (UCM) analysis performed on experimental data versus simulated data where the covariation (coordination) between particular joint motions was removed from the original data s...
Source: Experimental Brain Research - November 25, 2015 Category: Neuroscience Authors: Gera G, Freitas SM, Scholz JP Tags: Exp Brain Res Source Type: research

Variability, frequency composition, and temporal regularity of submaximal isometric elbow flexion force in subacute stroke.
Abstract We compared variability, frequency composition, and temporal regularity of submaximal isometric elbow flexion force at 10, 20, 35, and 50 % of peak torque between 34 stroke subjects (5-48 days post-onset, both arms) and 24 age-matched controls (dominant arm), and related the findings in the paretic arm to motor impairment. Force variability was quantified by the coefficient of variation (CV), frequency composition by the median frequency and relative power in 0-3-, 4-6-, and 8-12-Hz bands, and regularity by the sample entropy (SampEn). The paretic elbow flexors showed significantly increased CV and rela...
Source: Experimental Brain Research - June 30, 2016 Category: Neuroscience Authors: Chow JW, Stokic DS Tags: Exp Brain Res Source Type: research

Ipsilateral primary motor cortex and behavioral compensation after stroke: a case series study.
Abstract Arm motor recovery after stroke is mainly attributed to reorganization of the primary motor cortex (M1). While M1 contralateral to the paretic arm (cM1) is critical for recovery, the role of ipsilateral M1 (iM1) is still inconclusive. Whether iM1 activity is related to recovery, behavioral compensation, or both is still far from settled. We hypothesized that the magnitude of iM1 activity in chronic stroke survivors will increase or decrease in direct proportion to the degree that movements of the paretic arm are compensated. Movement kinematics (VICON, Oxford Metrics) and functional MRI data (3T MR syste...
Source: Experimental Brain Research - January 15, 2020 Category: Neuroscience Authors: Bani-Ahmed A, Cirstea CM Tags: Exp Brain Res Source Type: research

Gradual adaptation to pelvis perturbation during walking reinforces motor learning of weight shift toward the paretic side in individuals post-stroke
In conclusion, the "gradual adaptation" inducing "small errors" during constraint-induced walking may improve weight shift and enhance forced use of the paretic leg in individuals post-stroke. Applying gradual pelvis assistance force during walking may be used as an intervention strategy to improve walking in individuals post-stroke.PMID:33779790 | DOI:10.1007/s00221-021-06092-x
Source: Experimental Brain Research - March 29, 2021 Category: Neuroscience Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research

Motor evoked potential latency and duration from tibialis anterior in individuals with chronic stroke
This study assessed MEP onset latency and duration in the lower limb after stroke, and compared ipsilateral and contralateral MEPs in the paretic and non-paretic limb. We hypothesized that: (1) onset latency would be longer for ipsilateral than contralateral MEPs and longer for the paretic than the non-paretic limb, and (2) duration would be shorter for ipsilateral than contralateral MEPs and longer for the paretic than the non-paretic limb. Data were collected as a part of a pre-test of a randomized controlled trial. TMS was applied to the ipsilateral and contralateral hemisphere of the paretic and non-paretic limb. MEP o...
Source: Experimental Brain Research - June 1, 2021 Category: Neuroscience Authors: Brice T Cleland Emily Sisel Sangeetha Madhavan Source Type: research

Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Experimental Brain Research - January 7, 2023 Category: Neuroscience Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research

Variation of body  weight supported treadmill training parameters during a single session can modulate muscle activity patterns in post-stroke gait
Exp Brain Res. 2023 Jan 13. doi: 10.1007/s00221-023-06551-7. Online ahead of print.ABSTRACTEvidence supporting the benefits of locomotor training (LT) to improve walking ability following stroke are inconclusive and could likely be improved with a better understanding of the effects of individual parameters i.e., body weight support (BWS), speed, and therapist assistance and their interactions with walking ability and specific impairments. We evaluated changes in muscle activity of thirty-seven individuals with chronic stroke (> 6 months), in response to a single session of LT at their self-selected or fastest-comfortab...
Source: Experimental Brain Research - January 13, 2023 Category: Neuroscience Authors: Shraddha Srivastava Bryant A Seamon Carolynn Patten Steven A Kautz Source Type: research