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Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) admini...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research

Increased GABAergic inhibitory function against ischemic long-term potentiation in the CA1 region of the hippocampus.
In this study, iLTP was found to be induced in the hippocampal Schaffer-collateral pathway by exposure to oxygen glucose deprivation (OGD). Western blot analysis was conducted to analyze excitatory synaptic receptors and inhibitory synaptic receptors following OGD. The β3 subunit of the GABAA receptor (GABAAR) was markedly reduced, whereas the GluN2B subunit of the NMDAR was increased in the hippocampal area in the OGD group. Using extracellular recording, we demonstrated that application of GABAAR agonist midazolam could abolish the hippocampal iLTP. Moreover, midazolam had no significant effect on the increase in NMDAR ...
Source: Biochemical and Biophysical Research communications - March 28, 2020 Category: Biochemistry Authors: Chu MC, Lee JY, Lee HF, Chu KW, Wu HF, Lee CW, Lin CH, Tang CW, Lin HC Tags: Biochem Biophys Res Commun Source Type: research

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats
Publication date: Available online 21 September 2017 Source:Pharmacology Biochemistry and Behavior Author(s): Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl S. Pickering Pharmacological inhibition of PSD-95 is a promising therapeutic strategy in the treatment of stroke, and positive effects of monomeric and dimeric PSD-95 inhibitors have been reported in numerous studies. However, whether therapeutic effects will generalize to other types of acute brain injury such as traumatic brain injury (TBI), which has pathophysiological mechanisms in common with stroke, is currently uncertain...
Source: Pharmacology Biochemistry and Behavior - September 22, 2017 Category: Biochemistry Source Type: research

The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.
Abstract Flavonoids have been shown to improve cognitive function and delay the dementia progression. However, the underlying mechanisms remain elusive. In the present study, we examined the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTFs) extracted from S. baicalensis Georgi on spatial learning and memory in a vascular dementia (VaD) rat model and explored its molecular mechanisms. The VaD rats were developed by permanent bilateral occlusion of the common carotid artery. Seven days after recovery, the VaD rats were treated with either 50 or 100 mg/kg of SSTF for 60 days. The spatial learning a...
Source: Acta Biochimica et Biophysica Sinica - April 25, 2016 Category: Biochemistry Authors: Cao Y, Liang L, Xu J, Wu J, Yan Y, Lin P, Chen Q, Zheng F, Wang Q, Ren Q, Gou Z, Du Y Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Na ïve bayes classifier assisted automated detection of cerebral microbleeds in SWI brain images
Biochem Cell Biol. 2023 Aug 28. doi: 10.1139/bcb-2023-0156. Online ahead of print.ABSTRACTCerebral Microbleeds (CMBs) in the brain are the essential indicators of critical brain disorders such as dementia and ischemic stroke. Generally, CMBs are detected manually by experts which is an exhaustive task with limited productivity. Since, CMBs have complex morphological nature, so manual detection is prone to errors. This paper presents a machine learning-based automated Cerebral Microbleeds detection technique in the brain SWI scans based on statistical feature extraction and classification. The proposed method consists of th...
Source: Biochemistry and Cell Biology - August 28, 2023 Category: Biochemistry Authors: Tayyab Ateeq Zaid Bin Faheem Mohamed Ghoneimy Dr Jehad Ali PhD Computer Engineering Yang Li Abdullah Baz Source Type: research