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Condition: Alzheimer's
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Total 169 results found since Jan 2013.

Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa. 2022 Oct 6. doi: 10.1024/0301-1526/a001031. Online ahead of print.ABSTRACT Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production of ammonium, formaldehyde, methylglyoxal, and hydrogen peroxide. VAP-1 is mainly expressed by endothelial cells, smooth muscle cells, adipocytes and pericytes. It is involved in a repertoire of bi...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 6, 2022 Category: Surgery Authors: Marianna Danielli Roisin Clare Thomas Lauren Marie Quinn Bee Kang Tan Source Type: research

Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
Neural Regen Res. 2023 Jun;18(6):1165-1178. doi: 10.4103/1673-5374.357903.ABSTRACTT cells are essential for a healthy life, performing continuously: immune surveillance, recognition, protection, activation, suppression, assistance, eradication, secretion, adhesion, migration, homing, communications, and additional tasks. This paper describes five aspects of normal beneficial T cells in the healthy or diseased brain. First, normal beneficial T cells are essential for normal healthy brain functions: cognition, spatial learning, memory, adult neurogenesis, and neuroprotection. T cells decrease secondary neuronal degeneration,...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Mia Levite Source Type: research

Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease: PiB-PET-based study
Conclusions: Patients with PiB(–) SVaD were better at memory but worse at frontal function than patients with PiB(+) AD. The differences in memory/frontal functions observed between the 2 groups, however, could not differentiate all individual data due to some overlap in the cutoff threshold.
Source: Neurology - February 4, 2013 Category: Neurology Authors: Yoon, C. W., Shin, J. S., Kim, H. J., Cho, H., Noh, Y., Kim, G. H., Chin, J. H., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K.-H., Lee, J.-H., Seo, S. W., Na, D. L. Tags: All Cognitive Disorders/Dementia, Vascular dementia, Cognitive neuropsychology in dementia, Assessment of cognitive disorders/dementia ARTICLE Source Type: research

Could Antibodies or Hormones Slow Brain Damage from Alzheimer’s?
Scientists have discovered that certain antibodies may help slow the progression of Alzheimer’s disease. Dr. Patricia Salinas of University College London, UK, and her team focused on a protein called Dkk1, present in raised levels in the brains of people with Alzheimer’s disease. Using brain samples from mice, the team looked at the progressive disintegration of synapses in the hippocampus when exposed to a protein called amyloid-beta, thought to be central to the development of Alzheimer’s disease. “Synaptic loss mediated by amyloid-beta in early stages of the disease might contribute to cognitive...
Source: Psych Central - June 1, 2013 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Disorders General Seniors Abnormal Deposits Alzheimer S Disease Antibodies Brain Area Brain Damage Cognitive Decline Cognitive Impairments Disintegration Dr Patricia Dr Simon Hippocampus Journal Of Neurosc Source Type: news

Chronic over‐expression of TGFβ1 alters hippocampal structure and causes learning deficits
Abstract The cytokine Transforming Growth Factor β1 (TGFβ1) is chronically upregulated in several neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, Creutzfeldt‐Jacob disease, amyotrophic lateral sclerosis and multiple sclerosis, and following stroke. While previous studies have shown that TGFβ1 may be neuroprotective, chronic exposure to elevated levels of this cytokine may contribute to disease pathology on its own. In order to study the effects of chronic exposure to TGFβ1 in isolation we used transgenic mice that over‐express a constitutively active porcine TGFβ1 in astrocytes. W...
Source: Hippocampus - June 27, 2013 Category: Neurology Authors: Alonso Martinez‐Canabal, Anne L. Wheeler, Dani Sarkis, Jason P. Lerch, Wei‐Yang Lu, Marion S. Buckwalter, Tony Wyss‐Coray, Sheena A. Josselyn, Paul W. Frankland Tags: Research Article Source Type: research

Test could give two-year warning for Alzheimer's
Conclusion The researchers suggest that Alzheimer's disease can be predicted with an accuracy of 87.5% when thinning of the cortex in the right anterior cingulated gyrus is seen on MRI, alongside test results suggesting problems with recall and recognition. This research does not indicate a new "test", as MRI and psychological testing are standard procedures when investigating the signs and symptoms of dementia. What is novel in this approach is looking at a specific combination of results as a potential way of predicting which people with MCI may develop Alzheimer's disease. While this form of testing would be b...
Source: NHS News Feed - December 9, 2013 Category: Consumer Health News Tags: Neurology Source Type: news

Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: Can early neural stem cell grafting intervention provide protection?
This article is part of a Special Issue entitled NEWroscience 2013. PMID: 24433836 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - January 13, 2014 Category: Neurology Authors: Shetty AK Tags: Epilepsy Behav Source Type: research

Application of the Braden Scale in the home setting: incidence and factors associated with pressure ulcers
CONCLUSION: The Braden Scale was effective in the home environment to predict the onset of pressure ulcers. The incidence of pressure ulcers in homecare monitoring was 20%, and the associated factors were the degree in the Homecare Monitoring Program, Alzheimer and activities of daily living.
Source: Acta Paulista de Enfermagem - February 25, 2014 Category: Nursing Source Type: research

Longevity gene may boost brain power
(NIH/National Institute of Neurological Disorders and Stroke) Scientists showed that people who have a variant of a longevity gene, called KLOTHO, have improved brain skills such as thinking, learning and memory regardless of their age, sex, or whether they have a genetic risk factor for Alzheimer's disease. Increasing KLOTHO gene levels in mice made them smarter, possibly by increasing the strength of connections between nerve cells in the brain. The study was partly funded by the National Institutes of Health.
Source: EurekAlert! - Biology - May 9, 2014 Category: Biology Source Type: news

Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
Conclusion:Chronic administration of dl-PHPB improves learning and memory and promotes LTP in the animal models of Alzheimer's disease, possibly via increasing p-GluN2B expression in the hippocampus. PMID: 24858312 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 26, 2014 Category: Drugs & Pharmacology Authors: Li PP, Wang WP, Liu ZH, Xu SF, Lu WW, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research

Test Validity and Performance Validity: Considerations in Providing a Framework for Development of an Ability-Focused Neuropsychological Test Battery.
Abstract Literature on test validity and performance validity is reviewed to propose a framework for specification of an ability-focused battery (AFB). Factor analysis supports six domains of ability: first, verbal symbolic; secondly, visuoperceptual and visuospatial judgment and problem solving; thirdly, sensorimotor skills; fourthly, attention/working memory; fifthly, processing speed; finally, learning and memory (which can be divided into verbal and visual subdomains). The AFB should include at least three measures for each of the six domains, selected based on various criteria for validity including sensitivi...
Source: Archives of Clinical Neuropsychology - October 3, 2014 Category: Psychiatry & Psychology Authors: Larrabee GJ Tags: Arch Clin Neuropsychol Source Type: research