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Total 131 results found since Jan 2013.
Evaluation of laser bacterial anti ‐fouling of transparent nanocrystalline yttria‐stabilized‐zirconia cranial implant
ConclusionsOur results show that E. coli biofilm formation across the thickness of the nc‐YSZ implant can be disrupted using NIR laser treatment. The results of this in vitro study suggest that using nc‐YSZ as a cranial implant in vivo may also allow for locally selective, non‐invasive, chronic treatment of bacterial layers (fouling) that might form under cranial implants, without causing adverse thermal damage to the underlying host tissue when appropriate laser parameters are used. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc.
Source: Lasers in Surgery and Medicine - July 7, 2016 Category: Laser Surgery Authors: Yasaman Damestani, Natalie De Howitt, David L. Halaney, Javier E. Garay, Guillermo Aguilar Tags: Basic Science Source Type: research
P08.46 Rechallenge with bevacizumab in a long-term survivor with glioblastoma
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Koeppen, S., Hense, J. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research
Atim-02. successful cancer-selective gene delivery following intravenous toca 511 delivery in patients with recurrent high grade glioma (hgg)
This study demonstrates successful gene transduction following IV delivery of Toca 511 and shows encouraging survival data. Updated safety and efficacy data will be presented.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Cloughesy, T., Walbert, T., Bota, D., Vogelbaum, M., Liau, L., Ostertag, D., Jolly, D., Gruber, H., Yang, L., Shorr, J., Kalkanis, S. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research
Atim-18. phase i dose escalation study of d2c7-it administered intratumorally via convection-enhanced delivery (ced) for recurrent malignant glioma (mg)
CONCLUSION:Infusion of D2C7-IT via CED is safe thus far and encouraging efficacy results are observed. Enrollment is ongoing.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Desjardins, A., Randazzo, D., Chandramohan, V., Sampson, J., Peters, K., Vlahovic, G., Threatt, S., Herndon, J., Boulton, S., Lally-Goss, D., Healy, P., Lipp, E., Friedman, A., Friedman, H., Bigner, D. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research
Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research
Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin
Venous thromboembolism occurs in up to one-third of patients with primary brain tumors. Spontaneous intracranial hemorrhage (ICH) is also a frequent occurrence in these patients, but there is limited data on the safety of therapeutic anticoagulation. To determine the rate of ICH in patients treated with enoxaparin, we performed a matched, retrospective cohort study with blinded radiology review for 133 patients with high-grade glioma. After diagnosis of glioma, the cohort that received enoxaparin was 3 times more likely to develop a major ICH than those not treated with anticoagulation (14.7% vs 2.5%; P = .036; hazard rati...
Source: Blood - June 22, 2017 Category: Hematology Authors: Mantia, C., Uhlmann, E. J., Puligandla, M., Weber, G. M., Neuberg, D., Zwicker, J. I. Tags: Free Research Articles, Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: research
Functional brain mapping: overview of techniques and their application to neurosurgery
This article reviews the physical principles, applications, merits, shortcomings, and latest developments of nine FBM techniques. Other than neurosurgical operations, these techniques have also been applied to studies of stroke, Alzheimer’s, and cognition. There are strong indications that the future of brain mapping shall see the non-invasive techniques playing a more dominant role as they become more sensitive and accurate due to advances in physics, refined algorithms, and subsequent validation against invas ive techniques.
Source: Neurosurgical Review - July 13, 2018 Category: Neurosurgery Source Type: research
Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - August 10, 2018 Category: Neurology Source Type: research
Features of diffuse gliomas that are misdiagnosed on initial neuroimaging: a case control study
ConclusionSeveral clinical and radiologic metrics are associated with diffuse gliomas that are missed or misdiagnosed on the initial neuroimaging study. Knowledge of these associations may aid in avoiding misinterpretation and accurately diagnosing such cases in clinical practice.
Source: Journal of Neuro-Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research
Targeting pericytes for therapeutic approaches to neurological disorders
AbstractMany central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood–brain barrier. Pericytes, an u nder-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood–brain barrier, capillary blood flow and the movement of immune cells into the brain. They also form part of the “glial” scar isolating damaged parts of the CN...
Source: Acta Neuropathologica - October 1, 2018 Category: Neurology Source Type: research
Features of diffuse gliomas that are misdiagnosed on initial neuroimaging: a case control study
ConclusionSeveral clinical and radiologic metrics are associated with diffuse gliomas that are missed or misdiagnosed on the initial neuroimaging study. Knowledge of these associations may aid in avoiding misinterpretation and accurately diagnosing such cases in clinical practice.
Source: Journal of Neuro-Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research
Evaluating Spelling in Glioma Patients Undergoing Awake Surgery: a Systematic Review
AbstractA main goal of awake surgery is to preserve language in order to facilitate return to work and maintain quality of life. Although spelling has become crucial in daily life, it has received little attention in awake surgery practice. We review assessments of spelling carried out in awake surgery studies, to inspect how current neurofunctional theories of spelling may guide pre-, intra- and post-operative neurosurgical practice. A systematic database search in Embase, Medline, PubMed and Web of Science identified studies reporting on spelling assessment in glioma patients undergoing awake surgery. Twenty-three studie...
Source: Neuropsychology Review - December 21, 2018 Category: Neuroscience Source Type: research
Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.
In this study, we investigated the protective effects of alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, on glutamate-induced cytotoxicity in cultured C6 astroglial cells. Exposure to high-dose glutamate (10 mM) caused oxidative stress and mitochondrial dysfunction through the elevation of reactive oxygen species, depletion of glutathione, and loss of the mitochondrial membrane potential (ΔΨm). Pretreatment with ALA (200 µM), however, significantly inhibited the glutamate-induced oxidative stress and mitochondrial dysfunction. ALA pretreatment dose-dependently suppressed glutamate-induced apoptotic...
Source: Biological and Pharmaceutical Bulletin - January 6, 2019 Category: Drugs & Pharmacology Authors: Park E, Gim J, Kim DK, Kim CS, Chun HS Tags: Biol Pharm Bull Source Type: research
Study unveils a blueprint for treating a deadly brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients' tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy.
Source: EurekAlert! - Cancer - February 19, 2019 Category: Cancer & Oncology Source Type: news
How cost-effective is intraoperative MRI for gliomas?
Using a simulated clinical decision analysis model, researchers from the University...Read more on AuntMinnie.comRelated Reading:
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MRI for knee pain adds cost with negligible benefit
Source: AuntMinnie.com Headlines - April 2, 2019 Category: Radiology Source Type: news
