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Total 1194 results found since Jan 2013.

Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes
This study suggests that endothelial-specific ATX leads to increased LPA in the brain vasculature following ischemic-reperfusion and ultimately disrupts vascular permeability, resulting in adverse stroke outcomes.PMID:36766854 | DOI:10.3390/cells12030511
Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Susmita Bhattarai Utsab Subedi Shrivats Manikandan Sudha Sharma Papori Sharma Chloe Miller Md Shenuarin Bhuiyan Srivatsan Kidambi Vassilis Aidinis Hong Sun Sumitra Miriyala Manikandan Panchatcharam Source Type: research

The interaction between intestinal microenvironment and stroke
CONCLUSION: The structure and function of the intestinal environment can influence neurological function and cerebral ischemic outcome. Improving the intestinal microenvironment by targeting the gut microbiota may be a new direction in treating stroke.PMID:37309254 | DOI:10.1111/cns.14275
Source: CNS Neuroscience and Therapeutics - June 13, 2023 Category: Neuroscience Authors: Linna Zhao Jie Xiao Songlin Li Yuying Guo Rong Fu Shengyu Hua Yuzheng Du Shixin Xu Source Type: research

The emerging role of microRNA in stroke.
Abstract MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that play a pivotal role in post-transcriptional gene regulation by binding to complementary sites in the 3'-untranslated region of messenger RNAs. In the past decade, their role in several human diseases, from cancer to cardiovascular disease, has been established by a wealth of evidence. Stroke is responsible for 10% of deaths worldwide and is one of the leading causes of disability. MiRNAs are involved in stroke risk factors including hypertension, atherosclerosis, atrial fibrillation, diabetes and dyslipidemia. The rol...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Koutsis G, Siasos G, Spengos K Tags: Curr Top Med Chem Source Type: research

Plasticity beyond peri-infarct cortex: Spinal up regulation of structural plasticity, neurotrophins, and inflammatory cytokines during recovery from cortical stroke.
Abstract Stroke induces pathophysiological and adaptive processes in regions proximal and distal to the infarct. Recent studies suggest that plasticity at the level of the spinal cord may contribute to sensorimotor recovery after cortical stroke. Here, we compare the time course of heightened structural plasticity in the spinal cord against the temporal profile of cortical plasticity and spontaneous behavioral recovery. To examine the relation between trophic and inflammatory effectors and spinal structural plasticity, spinal expression of brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), tumor necr...
Source: Experimental Neurology - November 26, 2013 Category: Neurology Authors: Sist B, Fouad K, Winship IR Tags: Exp Neurol Source Type: research

Nico touts studies using BrainPath to treat hemorrhagic stroke
Nico Corp today released data from 2 recently published studies which utilized its BrainPath Approach to treat hemorrhagic stroke, touting a 95% clot reduction and no mortalities associated with the device. The BrainPath system uses a shunt and specially designed instrumentation to give surgeons access to the subcortical section of the brain. The device won 510(k) clearance from the FDA last June for treating primary and secondary brain tumors, vascular abnormalities, intraventricular tumors or cysts. Data from the studies was published in the journals Neurosurgery and Operative Neurosurgery, the Indianapolis-based c...
Source: Mass Device - June 29, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Neurological Surgical Nico Corp. Source Type: news

Human stem cells transplanted into the rat stroke brain migrate to spleen via lymphatic and inflammation pathways.
This study is the first to demonstrate brain-to-periphery migration of stem cells, advancing the novel concept of harnessing the lymphatic system in mobilizing stem cells to sequester peripheral inflammation as a brain repair strategy. PMID: 30514806 [PubMed - as supplied by publisher]
Source: Haematologica - December 4, 2018 Category: Hematology Authors: Xu K, Lee JY, Kaneko Y, Tuazon JP, Vale F, van Loveren H, Borlongan CV Tags: Haematologica Source Type: research

Aspirin resistance and blood biomarkers in predicting ischemic stroke recurrence: An exploratory study
CONCLUSIONS: Majority of patients with recurrent stroke were elderly (>60 years), hypertensive, and non-compliant with aspirin. Aspirin resistance was an important factor in patients with antiplatelet compliance. Inflammatory biomarkers hsCRP, PLA2, and TNF-α were found to be significantly elevated in patients compared to controls.PMID:35372727 | PMC:PMC8973447 | DOI:10.4103/bc.bc_75_21
Source: Atherosclerosis - April 4, 2022 Category: Cardiology Authors: Prerana Dash Varun Kumar Singh Deepa Gautam Abhishek Pathak Anand Kumar Surendra Pratap Mishra Debabrata Dash Vijay Nath Mishra Deepika Joshi Rameshwar Nath Chaurasia Source Type: research

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke
ConclusionThis systematic analysis not only helps in the understanding of the changes in the gene expression profiles of both the brain and skull with ischemic injury but also reveals the association of the tumor immune microenvironment and cell death with ischemic stroke.
Source: Frontiers in Immunology - December 20, 2022 Category: Allergy & Immunology Source Type: research

Contralaterally transplanted human embryonic stem cell-derived neural precursor cells (ENStem-A) migrate and improve brain functions in stroke-damaged rats.
In this study, we investigated the fates of human embryonic stem cell (hESC)-derived NPCs (ENStem-A) for 8 weeks following transplantation into the side contralateral to the infarct region using 7.0T animal magnetic resonance imaging (MRI). T2- and T2*-weighted MRI analyses indicated that the migrating cells were clearly detectable at the infarct boundary zone by 1 week, and the intensity of the MRI signals robustly increased within 4 weeks after transplantation. Afterwards, the signals were slightly increased or unchanged. At 8 weeks, we performed Prussian blue staining and immunohistochemical staining using human-specifi...
Source: exp Mol Med - November 19, 2013 Category: Molecular Biology Authors: Chang DJ, Oh SH, Lee N, Choi C, Jeon I, Kim HS, Shin DA, Lee SE, Kim D, Song J Tags: Exp Mol Med Source Type: research