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Education: Lessons
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Anticoagulants for secondary prevention after acute myocardial infarction: Lessons from the past decade
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - February 1, 2014 Category: Drugs & Pharmacology Authors: Dan Atar, Christoph Bode, André Stuerzenbecher, Freek W. A. Verheugt Tags: Review Article Source Type: research
Correspondence Lessons from the SPS3 trial
We read with interest the results of the SPS3 trial (Aug 10, p 507). The SPS3 Study Group concluded that the use of a systolic-blood-pressure (SBP) target of less than 130 mm Hg is likely to be beneficial for patients with recent lacunar stroke. However, several comments should be made before we encourage clinicians to achieve more intensive blood pressure reduction.
Source: LANCET - February 8, 2014 Category: Journals (General) Authors: Luis Castilla-Guerra, María del Carmen Fernandez-Moreno Tags: Correspondence Source Type: research
Recruitment of participants to a multiple sclerosis trial: The CombiRx experience.
CONCLUSION: Participants can be enrolled successfully in a clinical trial for RRMS, but factors affecting the time to achieve the requirements needed to start screening can be unpredictable and problematic. Prospective planning by the sponsors and investigators, use of central institutional review boards (IRBs), master trial agreements and secure remote desktop access to the trial database may expedite trial implementation and participant recruitment. A good scientific research question with flexible study design and active involvement of the clinicians are important factors driving recruitment. Clinical trials can be impl...
Source: Clinical Trials - April 7, 2014 Category: Research Authors: Bhanushali MJ, Gustafson T, Powell S, Conwit RA, Wolinsky JS, Cutter GR, Lublin FD, Cofield SS Tags: Clin Trials Source Type: research
Integrating resident‐to‐resident teaching in interdisciplinary stroke education
Source: Medical Education - April 9, 2014 Category: Universities & Medical Training Authors: Analiz Rodriguez, Roy Strowd, Patrick Reynolds, Cedric Lefebvre Tags: Really Good Stuff: Lessons learned through innovation in medical education Source Type: research
Analysis of African plant reveals possible treatment for aging brain
A plant used for centuries by healers of São Tomé e Príncipe holds lessons for modern medicine, scientists report. A compound isolated from Voacanga africana protects cells from altered molecular pathways linked to Alzheimer’s disease, Parkinson’s disease and the neurodegeneration that often follows a stroke, they say.
Source: ScienceDaily Headlines - August 4, 2014 Category: Science Source Type: news
Organ-specific bleeding patterns of anticoagulant therapy: lessons from clinical trials.
Abstract
Anticoagulants are effective at preventing and treating thrombosis, but can cause bleeding. For decades, vitamin K antagonists (VKAs) have been the only available oral anticoagulants. The development of non-VKA oral anticoagulants (NOACs), which inhibit either factor Xa or thrombin stoichiometrically, has provided alternatives to VKAs for several indications. The results of recent large-scale randomised controlled trials comparing NOACs with VKAs for the prevention of stroke in patients with non-valvular atrial fibrillation (AF) have produced some unexpected results. As a group, NOACs showed similar effic...
Source: Thrombosis and Haemostasis - September 4, 2014 Category: Hematology Authors: Vanassche T, Hirsh J, Eikelboom JW, Ginsberg JS Tags: Thromb Haemost Source Type: research
Erythropoietin and organ protection: lessons from negative clinical trials
Based on its pleiotropic effects, erythropoietin can decrease inflammation, oxidative stress, and apoptosis. Erythropoietin provides organ protection for the heart, brain, and kidney in diverse preclinical animal studies, especially models that include ischemia–reperfusion injury and/or inflammation. However, large clinical studies in coronary reperfusion, heart failure, stroke, acute kidney injury, and chronic renal disease have failed to demonstrate improved outcomes. A study in a previous issue of Critical Care examining the ability of erythropoietin to prevent or ameliorate acute kidney injury in patients undergoing ...
Source: Critical Care - September 11, 2014 Category: Intensive Care Authors: Ronald Pearl Source Type: research
1497p * lessons from the past: long-term safety and efficacy outcomes of a prematurely terminated, randomized phase iii trial of precautionary versus hemoglobin-based erythropoietin administration for chemotherapy-associated anemia in patients with solid tumors
Conclusions: Prophylactic administration of ESA for CIA in patients with solid tumors was associated with increased incidence of a composite of thrombosis-related adverse events, especially in patients receiving adjuvant treatment, but did not have a detrimental impact on relapse/progression and survival rates.Disclosure: All authors have declared no conflicts of interest.
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Mountzios, G., Aravantinos, G., Kouvatseas, G., Karina, M., Samantas, E., Papakostas, P., Skarlos, D., Galani, E., Kalofonos, H., Makatsoris, T., Bafaloukos, D., Pectasides, D. G., Fountzilas, G. Tags: supportive care Source Type: research
Make Halloween healthy: If you dare!
Meaghan O’Keeffe, RN, BSN, is a mother, writer and nurse. She worked at Boston Children’s Hospital for nearly a decade, in both the Cardiac Intensive Care Unit and the Pre-op Clinic. She is a regular contributor to Thriving.
Happy Halloween! This is a festive time of year when kids get excited to dress up in fantastical costumes and enjoy some light-hearted scares. But let’s be honest. Most kids dream about one thing and one thing only: the enormous bounty of candy that awaits them. Didn’t you?
Besides tasting great, sugar intake heightens the pleasure and reward centers of the brain. Feel-good hormones like dopa...
Source: Thrive, Children's Hospital Boston - October 21, 2014 Category: Pediatrics Authors: Meaghan O'Keeffe Tags: All posts Source Type: news
February Partner Spotlight
The Texas Diabetes Prevention and Control Program Incorporates NDEP Messages and Materials in its “Get Tested Today” Campaign
The Texas Diabetes Prevention and Control Program (DPCP) at the Texas Department of State Health Services
administers grant-funded initiatives and contracted services to address current issues affecting people with diabetes
and those at risk of getting diabetes. The Texas DPCP maintains a statewide system of quality education services for
all people with diabetes and health care professionals who offer diabetes treatment and educa...
Source: National Diabetes Education Program - January 31, 2014 Category: Endocrinology Source Type: news
Excellent Outcomes for Transcatheter Aortic Valve Replacement Within 1 Year of Opening a Low-Volume Centre and Consideration of Requirements
Conclusions Excellent outcomes can be achieved in newly initiated relatively low-volume centres, which compares favorably to previously published large series. Important considerations include appropriate team training, rigorous patient screening, use of multimodality imaging techniques, a heart team approach, constant integration of lessons learned from larger published experiences, and maintaining a recommended minimum volume of 25 cases per year.
Source: Canadian Journal of Cardiology - December 9, 2014 Category: Cardiology Source Type: research
Preoperative atrial fibrillation and outcome in patients undergoing on-pump or off-pump coronary bypass surgery: lessons learned from the GOPCABE trial
CONCLUSIONS
AF at admission is a significant risk factor for elderly patients undergoing coronary bypass grafting. However, this risk is not altered by performing bypass grafting off pump.
Source: Interactive CardioVascular and Thoracic Surgery - December 18, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Boning, A., Diegeler, A., Hilker, M., Zacher, M., Reents, W., Faerber, G., Doenst, T., for the GOPCABE investigators Tags: Molecular biology, Myocardial infarction, Myocardial protection, Transplantation - heart Adult Cardiac Source Type: research
Prayers, Facebook and Weight Loss
"When people talk to God, it is called prayer. When God talks to people, they call it schizophrenia." -- Dr. Jim Roach in his upcoming book, God's House Calls
"Just like a prayer. Your voice can take me there" -- Madonna
Until recently, my attitude toward prayer had been guided by President Harry S. Truman who said that "people who pray the loudest are the ones you lock your hen house from." I've always been intensely suspicious of anyone who seems too overt in their embrace of prayer, especially if the conversation deviates to matters concerning my checkbook or wallet.
Praying out loud was something I never did. Unti...
Source: Healthy Living - The Huffington Post - December 20, 2014 Category: Consumer Health News Source Type: news
Significant Period Between Presentation and Diagnosis in Basilar Artery Occlusion: Five Cases and the Lessons Learned Illustrative Teaching Case
Source: Stroke - March 23, 2015 Category: Neurology Authors: Organek, N., Milano, N., Donohue, M., Sundararajan, S., Strbian, D., Katzan, I. L. Tags: Acute Cerebral Infarction Illustrative Teaching Case Source Type: research
Staff’s views on delivering patient-led therapy during inpatient stroke rehabilitation: a focus group study with lessons for trial fidelity
Conducting rehabilitation interventions during clinical trials can be difficult; insights from staff delivering a complex rehabilitation intervention revealed key areas for improvement, including building confidence for patient identification and adapting treatments to individuals’ needs.
Source: Trials - April 7, 2015 Category: Journals (General) Authors: Maria HorneNessa ThomasAndy VailRudd SellesCandy McCabeSarah Tyson Source Type: research
