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Condition: von Willebrand Disease

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Total 292 results found since Jan 2013.

Adiposity, Adipokines, and Risk of Incident Stroke in Older Men Original Contributions
Conclusions— Conventional adiposity measures were not associated with increased stroke risk in older men. However, leptin (a good marker of percent fat mass), but not adiponectin, predicted stroke, suggesting a link between fat mass and stroke risk.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Wannamethee, S. G., Shaper, A. G., Whincup, P. H., Lennon, L., Sattar, N. Tags: Acute Cerebral Infarction, Risk Factors for Stroke, Epidemiology Original Contributions Source Type: research

Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke Clinical Sciences
Background and Purpose—von Willebrand factor (vWF) plays an important role in thrombus formation during cerebrovascular damage. We sought to investigate the potential role of circulating vWF in recurrent cerebrovascular events and identify genetic contributors to variation in vWF level in an ischemic stroke population.Methods—We analyzed the effect of circulating vWF on risk of recurrent stroke using survival models in the VISP trial (Vitamin Intervention for Stroke Prevention) and the use of vWF in reclassification over traditional factors. We conducted a genome-wide association study) with imputation, based on 1000 G...
Source: Stroke - May 22, 2017 Category: Neurology Authors: Stephen R. Williams, Fang–Chi Hsu, Keith L. Keene, Wei–Min Chen, Godfrey Dzhivhuho, Joe L. Rowles III, Andrew M. Southerland, Karen L. Furie, Stephen S. Rich, Bradford B. Worrall, Michele M. Sale Tags: Biomarkers, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Combined Elevation of FVIII and von Willebrand Factor Predicts Risk for Worse Outcomes in Patients with Acute Ischemic Stroke (AIS) (P7.152)
CONCLUSIONS:Concurrent elevation in FVIII and vWF predicts higher odds of worse outcomes for AIS patients. Our findings suggest that FVIII and vWF levels may serve as clinically useful stroke biomarkers by providing risk profiles for stroke patients on admission with a hypercoagulable state.Disclosure: Dr. Samai has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. George has received research support from Tulane University School of Medicine. Dr. Dowell has nothing to disclose. Dr. Schluter has nothing to disclose. Dr. El Khoury has nothing to disclose. Dr. Martin-Schild has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Samai, A., Monlezun, D., George, A., Dowell, L., Schluter, L., El Khoury, R., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Predictors of Outcome After Ischemic Stroke Source Type: research

Von Willebrand Factor Drives the Association Between Elevated Factor VIII and Poor Outcomes in Patients With Ischemic Stroke Brief Reports
Conclusions— Concurrent FVIII/vWF elevation predicts higher odds of inpatient complications, neuroworsening, and worse functional outcomes for patients with AIS compared with patients with normal levels. Our findings suggest that FVIII and vWF levels may serve as clinically useful stroke biomarkers by providing risk profiles for patients with AIS.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Samai, A., Monlezun, D., Shaban, A., George, A., Dowell, L., Kruse-Jarres, R., Schluter, L., El Khoury, R., Martin-Schild, S. Tags: Coagulation, Thrombophilia, Acute Cerebral Infarction Brief Reports Source Type: research

Biomarkers and Mortality After Transient Ischemic Attack and Minor Ischemic Stroke: Population-Based Study Clinical Sciences
Conclusions— Several biomarkers predicted death of any cause after transient ischemic attack and minor stroke. N-terminal pro-B-type natriuretic peptide and heart-type fatty-acid-binding protein might improve patient selection for additional screening for occult cardiac disease or cancer, respectively. However, our results require validation in future studies.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Greisenegger, S., Segal, H. C., Burgess, A. I., Poole, D. L., Mehta, Z., Rothwell, P. M. Tags: Epidemiology Clinical Sciences Source Type: research

High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV‐infected patients
ConclusionsStroke in human immunodeficiency virus infection is associated with a prothrombotic state, characterized by elevated von Willebrand factor and low ADAMTS13 levels.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Sameera Allie, Alan Stanley, Alan Bryer, Muriel Meiring, Marc I. Combrinck Tags: Research Source Type: research

Evolutional Characterization of Photochemically Induced Stroke in Rats: a Multimodality Imaging and Molecular Biological Study
In conclusion, these characterizations may be highly beneficial to the development of therapeutic strategies for ischemi c stroke.
Source: Translational Stroke Research - November 30, 2016 Category: Neurology Source Type: research

Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences
Conclusions— Prothrombotic blood alterations could be involved in the LAA thrombus formation in patients without documented atrial fibrillation and are associated with increased risk of stroke or transient ischemic attack during follow-up.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Meus, R., Son, M., Sobczyk, D., Undas, A. Tags: Ischemic Stroke Clinical Sciences Source Type: research

Rare Variants in the ADAMTS13 Von Willebrand Factor-Binding Domain Contribute to Pediatric Stroke Original Articles
Conclusions— Our data provide a link between the genetic architecture of ADAMTS13, ADAMTS13 levels, and stroke susceptibility. Altogether, these studies render ADAMTS13 an attractive candidate for functional studies and may contribute to personalized diagnosis and treatment options in future.
Source: Circulation: Cardiovascular Genetics - August 15, 2016 Category: Cardiology Authors: Stoll, M., Ruhle, F., Witten, A., Barysenka, A., Arning, A., Strauss, C., Nowak-Gottl, U. Tags: Cardiovascular Disease, Genetic, Association Studies, Ischemic Stroke, Thrombosis Original Articles Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV ‐infected patients
International Journal of Stroke,Volume 10, Issue 8, Page 1294-1296, December 2015.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Source Type: research

Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke
AbstractThe role of miR-503 in brain endothelium and ischemic stroke (IS) remains unclear. We aimed to study the relationship between plasma miR-503 and the onset time, severity, subtypes, and von Willebrand Factor (vWF) level in IS patients and to investigate the roles and underlying mechanisms of miR-503 in middle cerebral artery occlusion (MCAO) mice and cultured cerebral vascular endothelial cells (ECs). In MCAO mice, the effects of plasma from acute severe IS patients (ASS) with or without miR-503 antagomir on brain and ECs damage were determined. In cultured human ECs, the effects of miR-503 overexpression or knockdo...
Source: Translational Stroke Research - April 13, 2020 Category: Neurology Source Type: research

High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
Conclusions 3D-SEM provides novel and potentially clinically relevant information on clot components and ultrastructure which may help to inform thrombolytic treatment and medical device design.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Mereuta, O. M., Fitzgerald, S., Christensen, T. A., Jaspersen, A. L., Dai, D., Abbasi, M., Puttappa, T., Kadirvel, R., Kallmes, D. F., Doyle, K. M., Brinjikji, W. Tags: Ischemic stroke Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research