Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences

Background and Purpose— We hypothesized that formation of left atrial appendage (LAA) thrombi of unknown origin is associated with altered fibrin clot properties and blood hypercoagulability. Methods— In a case–control study, we investigated 32 patients with a history of LAA thrombus after successful anticoagulant treatment versus 32 control subjects matched for age, sex, and diabetes mellitus. All subjects had previous ischemic stroke, transient ischemic attack, or migraine associated with patent foramen ovale. Patients with documented atrial fibrillation were excluded. We determined plasma fibrin clot permeability, fibrinolytic efficiency, thrombin generation, platelet and endothelial markers. Stroke or transient ischemic attack were assessed during a median follow-up of 74 (range 19–98) months. Results— Compared with controls, patients with LAA thrombus more frequently were smokers (43.8% versus 18.8%) and had 20% prolonged clot lysis time, lower plasminogen (–14%), and higher plasminogen activator inhibitor-1 (+17%), thrombin–antithrombin complexes (+17%), CD40 ligand (+30%), P-selectin (+29%), and von Willebrand factor (+30%, all P
Source: Stroke - Category: Neurology Authors: Tags: Ischemic Stroke Clinical Sciences Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
Two Clinical Nurse Specialist opportunities are available to contribute towards the provision of excellent patient care within our Endocrinology and Diabetes Service.One post will be for our Queen Elizabeth Hospital (QEHB) site and the other for our Heartlands, Good Hope and Solihull Hospital site (HGS). Successful candidates will join a team of experienced specialist nurses in a tertiary Endocrine referral centre and will be given full structured training and supervision to develop their skills in Endocrinology.Application deadline is2 February 2020. Visit www.jobs.nhs.uk for full details and to apply. 
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Researchers reports an over 50% drop in overall death rates among people with diabetes living in Hong Kong from 2001-2016; younger people with diabetes less likely to experience improvement in survival, however.Medscape Medical News
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Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.06
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion Anlotinib effectively controlled the growth of NSCLC and improved TAO related symptoms. Anlotinib maybe normalize disordered growth of blood vessels through the VEGF signaling pathway, rather than simply inhibiting angiogenesis. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.10
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Authors: Baumann S, Bojara W, Post H, Rudolph T, Schäufele T, Ong P, Lehmann R, von Zur Mühlen C Abstract The regulation of coronary flow is mainly located in the resistance vessels of the microcirculation, so that the functional relevance of a coronary stenosis arises from the interaction between the epicardial stenosis and the downstream microcirculation. These complex interactions are precisely detectable by physiological measurements, such as the instantaneous wave-free ratio (iwFR) or the fractional flow reserve (FFR). In contrast, the purely visual assessment of the coronary anatomy could lead ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Authors: Saritas T, Floege J Abstract Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therap...
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Publication date: Available online 16 January 2020Source: Life SciencesAuthor(s): Milad Ashrafizadeh, Zahra Ahmadi, Saeed Samarghandian, Reza Mohammadinejad, Habib Yaribeygi, Thozhukat Sathyapalan, Amirhossein SahebkarAbstractMicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable of preventing oxidative damages by modulating antioxidant defense systems in a variety of milieu, such as in diabetes. Although the exact molecular mechan...
Source: Life Sciences - Category: Biology Source Type: research
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