Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences

Background and Purpose— We hypothesized that formation of left atrial appendage (LAA) thrombi of unknown origin is associated with altered fibrin clot properties and blood hypercoagulability. Methods— In a case–control study, we investigated 32 patients with a history of LAA thrombus after successful anticoagulant treatment versus 32 control subjects matched for age, sex, and diabetes mellitus. All subjects had previous ischemic stroke, transient ischemic attack, or migraine associated with patent foramen ovale. Patients with documented atrial fibrillation were excluded. We determined plasma fibrin clot permeability, fibrinolytic efficiency, thrombin generation, platelet and endothelial markers. Stroke or transient ischemic attack were assessed during a median follow-up of 74 (range 19–98) months. Results— Compared with controls, patients with LAA thrombus more frequently were smokers (43.8% versus 18.8%) and had 20% prolonged clot lysis time, lower plasminogen (–14%), and higher plasminogen activator inhibitor-1 (+17%), thrombin–antithrombin complexes (+17%), CD40 ligand (+30%), P-selectin (+29%), and von Willebrand factor (+30%, all P
Source: Stroke - Category: Neurology Authors: Tags: Ischemic Stroke Clinical Sciences Source Type: research

Related Links:

Publication date: Available online 20 September 2020Source: Materials Today: ProceedingsAuthor(s): Mohd Javeed Mehdi, N Srinivasrao, A Sireesha
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Presentation of CF, airway clearance regimens, diabetes in CF, and other highlights from the cystic fibrosis episode of The Cribsiders podcast.Medscape Pediatrics
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics Commentary Source Type: news
CONCLUSIONS: Glecaprevir/pibrentasvir was effective and well tolerated in treatment-naïve Brazilian patients with hepatitis C infection without cirrhosis and with compensated cirrhosis. TRIAL REGISTRATION: ClinicalTrials.gov NCT03219216. PMID: 32949786 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
CONCLUSION: Type 4 collagen could predict the presence of significant and advanced fibrosis in NAFLD patients and it would be a useful tool in routine clinical practice. PMID: 32949785 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
Publication date: Available online 21 September 2020Source: Biosensors and BioelectronicsAuthor(s): Sujasha Gupta, Subhadip Ghatak, Travis Hery, Savita Khanna, Mohamed El-Masry, Vishnu Baba Sundaresan, Chandan K. Sen
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
This article aims to re...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study aims to explore the factors that affect e-bike usage by stroke survivors. METHODS: A mixed methods multiple ca...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Pedestrians and Bicycles Source Type: news
We would like to thank Dr Paraskevas for his comments on our report, “Asymptomatic carotid stenosis is associated with mobility and cognitive dysfunction and heightens falls in older adults.”1 These results extend our earlier findings of cognitive decline observed in asymptomatic carotid artery stenosis that we found were associated with attendant altered blood f low and cerebral hypoperfusion.2 We agree that although intensive medical management in these patients reduces the risk for atheroembolic stroke, it might not necessarily target the mechanisms that contribute to declines in mobility and cognitive function.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
There are many other professions that pay similarly or more that don’t have the headaches dentistry has. I remember most of my classmates saying they chose dentistry due to the hours and workload MDs have to deal with. But looking at dentistry not sure it is much better. The median pay is obviously much worse. But it seems only a few of us dentists are willing to acknowledge this. Saving face is unfortunately a big thing in our profession.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Dental Residents and Practicing Dentists Source Type: forums
Condition:   Bleeding Interventions:   Drug: Wilate;   Other: Placebo Sponsor:   University Hospital, Basel, Switzerland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Atrial Fibrillation | Diabetes | Diabetes Mellitus | Endocrinology | Headache | Ischemic Stroke | Migraine | Neurology | Patent Foramen Ovale | Smokers | Stroke | Study | Thrombosis | von Willebrand Disease