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A simple score to predict atherosclerotic or embolic intracranial large-vessel occlusion stroke before endovascular treatment
CONCLUSIONS: The atrial fibrillation-blood pressure-clinical neurological deficit-computed tomography hyperdense sign-diabetes mellitus (ABC2D) score can be used to identify atherosclerotic or embolic etiology of patients with ILVOS who require emergency endovascular treatment.PMID:35303701 | DOI:10.3171/2022.1.JNS212924
Source: Journal of Neurosurgery - March 18, 2022 Category: Neurosurgery Authors: Geng Liao Zhenyu Zhang Tao-Hsin Tung Yuemei He Linhui Hu Xiong Zhang Hai Chen Jinbo Huang Weijie Du Chaomao Li Zhi Yang Yong Cai Hanxiang Liang Source Type: research

Increased incidence and treatment of intracranial atherosclerotic disease during mechanical thrombectomy is safe, even with an increased number of passes
Conclusion Patients who underwent MT with underlying ICAD had similar rates of favorable outcomes as those without, but required a higher number of device passes.
Source: Journal of NeuroInterventional Surgery - February 16, 2022 Category: Neurosurgery Authors: Monayao, M. C., Malik, A. A., Preston, L., Monayao Sr, M. C., Tekle, W., Hassan, A. E. Tags: Ischemic stroke Source Type: research

Early versus late start of direct oral anticoagulants after acute ischaemic stroke linked to atrial fibrillation: an observational study and individual patient data pooled analysis
Conclusions Our results do not corroborate concerns that an early DOAC-start might excessively increase the risk of ICH. The sevenfold higher risk of recurrent AIS than ICH suggests that an early DOAC-start might be reasonable, supporting enrolment into randomised trials comparing an early versus late DOAC-start.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 17, 2022 Category: Neurosurgery Authors: De Marchis, G. M., Seiffge, D. J., Schaedelin, S., Wilson, D., Caso, V., Acciarresi, M., Tsivgoulis, G., Koga, M., Yoshimura, S., Toyoda, K., Cappellari, M., Bonetti, B., Macha, K., Kallmünzer, B., Cereda, C. W., Lyrer, P., Bonati, L. H., Paciaron Tags: Cerebrovascular disease Source Type: research

Cerebral hyperperfusion syndrome after mechanical thrombectomy
Case summary A male patient in his late 50s who had untreated atrial fibrillation received mechanical thrombectomy for right middle cerebral artery occlusion (MCA), with complete recanalization. After initial neurological improvement, he developed headache and altered vigilance 2 days post-thrombectomy. Transcranial duplex sonography (TCD) showed increased blood flow velocities in the entire ipsilateral (recanalized) MCA-M1 segment.1 2 Brain MRI with angiography excluded focal stenosis and showed vasogenic edema, hemorrhagic transformation of the ischemic infarct, and cerebral hyperperfusion in the right MCA territory (fig...
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: Kneihsl, M., Enzinger, C., Gattringer, T. Tags: Ischemic stroke Source Type: research

Differential effect of mechanical thrombectomy and intravenous thrombolysis in atrial fibrillation associated stroke
Conclusions In patients treated with MT, comorbid AF is associated with faster procedural time, fewer passes, and increased rates of first pass success without increased risk of intracranial hemorrhage or worse functional outcomes. These results are in contrast to the increased hemorrhage rates and worse functional outcomes observed in AF associated stroke treated with supportive care and or IVT. These data suggest that MT negates the AF penalty in ischemic stroke.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Akbik, F., Alawieh, A., Cawley, C. M., Howard, B. M., Tong, F. C., Nahab, F., Saad, H., Dimisko, L., Mustroph, C., Samuels, O. B., Pradilla, G., Maier, I., Goyal, N., Starke, R. M., Rai, A., Fargen, K. M., Psychogios, M. N., Jabbour, P., De Leacy, R., Gil Tags: Ischemic stroke Source Type: research

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke
Conclusions An assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Itsekson Hayosh, Z., Abu Bandora, E., Shelestovich, N., Nulman, M., Bakon, M., Yaniv, G., Khaitovitch, B., Balan, S., Gerasimova, A., Drori, T., Mausbach, S., Schwammenthal, Y., Afek, A., Chapman, J., Shavit Stein, E., Orion, D. Tags: Ischemic stroke Source Type: research

LB-004 Intravenous alteplase has different effects on the efficacy of aspiration and stent retriever thrombectomy: analysis of the COMPASS trial
ConclusionsPrior administration of IV Alteplase is not associated with improved procedural or clinical outcomes in patients with anterior circulation ELVO treated with MT. Alteplase may adversely affect the efficacy of aspiration first approach, but does not seem to influence the stent retriever first approach to MT.DisclosuresM. Mokin: 1; C; NIH R21NS109575. 2; C; Cerenovus, Medtronic. 4; C; Brain Q, Endostream Serenity medical, Synchron. M. Waqas: None. J. Fifi: 2; C; Stryker, Penumbra, Microvention. 4; C; Cerebrotech, The Stroke Project. R. De Leacy: 2; C; Penumbra, Cerenovus, Siemens, Imperative Care. 4; C; Synchron, E...
Source: Journal of NeuroInterventional Surgery - July 29, 2021 Category: Neurosurgery Authors: Mokin, M., Waqas, M., Fifi, J., De Leacy, R., Fiorella, D., Levy, E., Snyder, K., Hanel, R., Woodward, K., Chaudry, I., Rai, A., Frei, D., Delgado Almandoz, J., Kelly, M., Arthur, A., Baxter, B., English, J., Linfante, I., Fargen, K., Turk, A., Mocco, J., Tags: Late-breaking oral abstracts Source Type: research

P-016 Association of cerebral microbleeds and clinical outcomes following endovascular stroke therapy
ConclusionOur analysis indicates that the presence of CMBs is not significantly associated with poor clinical outcome or the risk of ICH following EVT.Disclosures H. Saber: None. J. Saver: None. V. Szeder: None. M. Nour: None. K. Khatibi: None. L. Ponce Mejia: None. S. Tateshima: 2; C; Medtronic, Stryker, Cerenovus. G. Colby: 2; C; Medtronic, Stryker, MicroVention. N. Kaneko: None. R. Jahan: 2; C; Medtronic. G. Duckwiler: 2; C; Medtronic. D. Liebeskind: 2; C; Medtronic.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Saber, H., Saver, J., Szeder, V., Nour, M., Khatibi, K., Ponce Mejia, L., Tateshima, S., Colby, G., Kaneko, N., Jahan, R., Duckwiler, G., Liebeskind, D. Tags: Oral poster abstracts Source Type: research

P-036 Sensitivity of the RACW score in the detection of large vessel occlusions during working and non-working hours
ConclusionThe sensitivity of the RACE score for detecting large vessel occlusions does not vary significantly during working and non-working hours. However, patients who present with high RACE scores during working hours are more likely to have a diagnosis of a stroke mimic than those presenting off hours.Disclosures E. Hitomi: None. M. Jumaa: None. S. Zaidi: None. J. Shawver: None. A. Korsnack: None. A. Castonguay: None. R. Burgess: None. V. Kung: None. H. Salahuddin: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Hitomi, E., Jumaa, M., Zaidi, S., Shawver, J., Korsnack, A., Castonguay, A., Burgess, R., Kung, V., Salahuddin, H. Tags: Oral poster abstracts Source Type: research

P-043 Elevated D-dimer levels predicts mortality in COVID-19 with stroke: analysis of multi-center electronic health record data
ConclusionsPeak D-dimer levels above 5.15 µg/ml feu are associated with increased mortality in COVID-19 patients with AIS.Disclosures Y. Kim: None. S. Khose: None. R. Abdelkhaleq: None. S. Salazar-Marioni: None. S. Sheth: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Kim, Y., Khose, S., Abdelkhaleq, R., Salazar-Marioni, S., Sheth, S. Tags: Oral poster abstracts Source Type: research

E-003 Safety and efficacy of balloon guide catheters in thrombectomy for anterior circulation stroke: a systematic review and meta-analysis
ConclusionBGC use during MT for acute ischemic stroke is associated faster to groin-to-recanalization times, improved TICI ≥2b reperfusion, lower incidence of sICH, and lower mortality. These data demonstrate the promise of BGC use for MT and warrant further study.Disclosures N. Shlobin: None. B. Jahromi: None. S. Ansari: None. M. Potts: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Shlobin, N., Jahromi, B., Ansari, S., Potts, M. Tags: Electronic poster abstracts Source Type: research

E-025 Aspiration thrombectomy of acute ischemic stroke patients with intracranial atherosclerotic disease or tandem lesion
ConclusionAspiration thrombectomy was effective in restoring blood flow and resulting in good 90-day functional outcome in AIS patients with anterior circulation tandem lesion, and the 90-day mortality rate in these patients was low. No significant difference in outcomes was detected between patients with a stent and patients without a stent.Disclosures O. Zaidat: 1; C; Genentech, Medtronic Neurovascular, Stryker. 2; C; Codman, Medtronic Neurovascular, National Institutes of Health StrokeNet, Penumbra, Stryker. J. Fifi: 1; C; Microvention, Penumbra, Stryker. 2; C; Microvention, Stryker. 4; C; Imperative Care. A. Hassan: 2;...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Zaidat, O., Fifi, J., Hassan, A. Tags: Electronic poster abstracts Source Type: research

E-051 Disparities in stroke: Associating socioeconomic factors with ischemic stroke outcome
ConclusionsMedian income based on zip code is a SES indicator that is potentially associated with functional outcomes of ischemic stroke patients undergoing mechanical thrombectomy. Further studies addressing this relationship are needed.Disclosures A. Nguyen: None. G. M. Cortez: None. M. Baretta: None. A. Aghaebrahim: None. E. Sauvageau: None. R. Hanel: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Nguyen, A., Cortez, G., Baretta, M., Aghaebrahim, A., Sauvageau, E., Hanel, R. Tags: Electronic poster abstracts Source Type: research

E-067 Importance of First Pass Reperfusion in Endovascular Stroke Care - Insights from STAR
ConclusionThis analysis of a large, multi-center stroke database confirms the importance of first pass reperfusion in endovascular stroke care.Disclosures I. Maier: None. M. Psychogios: None. J. Liman: None. S. Al Kasab: None. E. Almallouhi: None. A. Alawieh: None. S. Wolfe: None. K. Fargen: None. A. Arthur: None. N. Goyal: None. T. Dumont: None. P. Kan: None. J. Kin: None. R. De Leacy: None. J. Osbun: None. A. Rai: None. P. Jabbour: None. J. Grossberg: None. M. Park: None. R. Starke: None. R. Crosa: None. A. Spiotta: None. D. Behme: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Maier, I., Psychogios, M., Liman, J., Al Kasab, S., Almallouhi, E., Alawieh, A., Wolfe, S., Fargen, K., Arthur, A., Goyal, N., Dumont, T., Kan, P., Kin, J., De Leacy, R., Osbun, J., Rai, A., Jabbour, P., Grossberg, J., Park, M., Starke, R., Crosa, R., Spi Tags: Electronic poster abstracts Source Type: research

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