Early versus late start of direct oral anticoagulants after acute ischaemic stroke linked to atrial fibrillation: an observational study and individual patient data pooled analysis

Conclusions
Our results do not corroborate concerns that an early DOAC-start might excessively increase the risk of ICH. The sevenfold higher risk of recurrent AIS than ICH suggests that an early DOAC-start might be reasonable, supporting enrolment into randomised trials comparing an early versus late DOAC-start.

Source: Journal of Neurology, Neurosurgery and Psychiatry - January 17, 2022 Category: Neurosurgery Authors: De Marchis, G. M., Seiffge, D. J., Schaedelin, S., Wilson, D., Caso, V., Acciarresi, M., Tsivgoulis, G., Koga, M., Yoshimura, S., Toyoda, K., Cappellari, M., Bonetti, B., Macha, K., Kallmünzer, B., Cereda, C. W., Lyrer, P., Bonati, L. H., Paciaron Tags: Cerebrovascular disease Source Type: research