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Specialty: Drugs & Pharmacology
Condition: Pain

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Total 111 results found since Jan 2013.

Proteomic Profiling in the Spinal Cord and Sciatic Nerve in a Global Cerebral Ischemia-Induced Mechanical Allodynia Mouse Model.
Abstract Central post-stroke pain (CPSP) is one of the complications of cerebral ischemia and neuropathic pain syndrome. At present, there are few studies of pain in regions such as the spinal cord or sciatic nerve in cerebral ischemic animal models. To identify proteomic changes in the spinal cord and sciatic nerve in global cerebral ischemic model mice, in the present study we performed an investigation using proteomic methods. In a comparison between the intensity of protein spots obtained from a sham and that from a bilateral carotid artery occulusion (BCAO) in spinal cord and sciatic nerve, the levels of 10 (...
Source: Biological and Pharmaceutical Bulletin - February 3, 2016 Category: Drugs & Pharmacology Authors: Harada S, Matsuura W, Takano M, Tokuyama S Tags: Biol Pharm Bull Source Type: research

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?
Abstract Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of...
Source: European Journal of Pharmacology - February 4, 2016 Category: Drugs & Pharmacology Authors: Javid FA, Phillips RM, Afshinjavid S, Verde R, Ligresti A Tags: Eur J Pharmacol Source Type: research

Safety of medical treatments for endometriosis.
Authors: Berlanda N, Somigliana E, Viganò P, Vercellini P Abstract INTRODUCTION: All medical treatments for endometriosis are equally effective in relieving pain. However, all of them alleviate pain symptoms for as long as they are used, but pain always relapses when medication is discontinued. Therefore, medications need to be used in the long term. AREAS COVERED: Formulations of estro-progestins that contain less than 50 µg of estrogen are associated with a low risk of venous thrombosis, myocardial infarction and stroke. When considering the neoplastic effects, data suggest that the overall risk of invasiv...
Source: Expert Opinion on Drug Safety - February 17, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Atypical chest pain in ACS: a trap especially for women.
Abstract Not all acute coronary syndromes (ACS) exhibit the classic symptoms of chest pain. The diagnosis of ACS in patients without typical chest pain is often challenging. These patients are at increased risk for delayed or incorrect diagnosis, less aggressive treatment and high in-hospital mortality. The association between diabetes mellitus and absence of chest pain in ischemic heart disease is established. As well, it is known that women, more frequently than men, have atypical presentation. However, there is a lack of standardization in characterizing the population of patients with ACS and atypical presenta...
Source: Current Pharmaceutical Design - March 8, 2016 Category: Drugs & Pharmacology Authors: Ricci B, Cenko E, Varotti E, Puddu PE, Manfrini O Tags: Curr Pharm Des Source Type: research

Safety Concerns for Sclerotherapy of Telangiectases, Reticular and Varicose Veins
Conclusion: Physicians practicing sclerotherapy should be aware of the possible local and systemic AE of sclerotherapy, inform patients accordingly and be prepared for the appropriate management of the rare but possibly lethal serious AE.Pharmacology 2016;98:62-69
Source: Pharmacology - April 22, 2016 Category: Drugs & Pharmacology Source Type: research

Safety of epidural steroid injections.
This article will outline the risks of ESIs and in doing so help shed light on the procedural risks versus the risks of the medication. Additionally, it will help differentiate minor adverse events from significant permanent complications. Expert Opinion: Catastrophic complications of ESI such as paralysis and stroke unquestionably warrant the recent increased attention given to the safety of these injections. While a single major complication is unacceptable, the relative rate of these major complications must be put in prospective. The true rate is small enough that it is impossible to calculate. All cases are limited to...
Source: Expert Opinion on Drug Safety - May 7, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Translational challenge models in support of efficacy studies: Neurobehavioral and cognitive changes induced by Transcranial Magnetic Stimulation in healthy volunteers.
Abstract Transcranial Magnetic Stimulation (TMS) was proposed as a neurophysiological tool almost three decades ago. It now encompasses a very wide range of applications including clinical research and the treatment of psychiatric, neurologic and medical conditions such as depression, schizophrenia, addictions, post-traumatic stress disorders, pain, migraine, stroke, Alzheimer's disease, autism, multiple sclerosis and Parkinson's disease. By inducing electrical brain responses through the administration of magnetic pulses, TMS is in a unique position to painlessly modulate cortical regions and offers good spatial ...
Source: CNS and Neurological Disorders Drug Targets - May 17, 2016 Category: Drugs & Pharmacology Authors: Martin-Trias P, Bragulat V, Peña-Gómez C, Sala-Llonch R, Lanteaume L, Cassé-Perrot C, Blin O, Micallef J, Auffret A, Bartrés-Faz D Tags: CNS Neurol Disord Drug Targets Source Type: research

A Central Role for ATP Signaling in Glial Interactions in the CNS.
Abstract The purine ATP has a prominent regulatory role in CNS function and pathology due to its actions on glial cells - microglia, astrocytes and oligodendrocytes. ATP serves as a ubiquitous 'gliotransmitter' that is released by astrocytes to activate purine receptors on neighbouring cells. In pathology, ATP release from glia and damaged cells mediates both tissue destruction and repair. The actions of ATP on glia are mediated via a wide range of receptors, broadly divided into ionotropic P2X and metabotropic (G-protein coupled receptors (GPCR) P2Y receptors, of which there are multiple subtypes (P2X1-P2X7 and P...
Source: Current Drug Targets - July 10, 2016 Category: Drugs & Pharmacology Authors: Rivera A, Vanzulli I, Butt AM Tags: Curr Drug Targets Source Type: research

11-dehydro thromboxane B2 levels after percutaneous transluminal angioplasty in patients with peripheral arterial occlusive disease during a one year follow-up period.
In this study, 175 patients diagnosed with peripheral arterial occlusive disease (PAOD) and demonstrating short-distance claudication or ischemic rest pain, requiring PTA in either the iliac, femoral, or popliteal arteries, were enrolled. The excretion of 11-dehydro thromboxane B2 (TXB2) was measured in urine samples by high-performance liquid chromatography-mass spectrometry and recalculated based on the creatinine concentration. The urine samples were collected the morning prior to PTA, immediately following PTA and the day after PTA. All of the study subjects were then observed for a period of 12 months. Urine samples w...
Source: J Physiol Pharmacol - May 31, 2016 Category: Drugs & Pharmacology Authors: Maga P, Sanak M, Jawien J, Rewerska B, Maga M, Wachsmann A, Koziej M, Gregorczyk-Maga I, Nizankowski R Tags: J Physiol Pharmacol Source Type: research

Proteomic Profiling in the Spinal Cord and Sciatic Nerve in a Global Cerebral Ischemia-Induced Mechanical Allodynia Mouse Model.
Abstract Central post-stroke pain (CPSP) is one of the complications of cerebral ischemia and neuropathic pain syndrome. At present, there are few studies of pain in regions such as the spinal cord or sciatic nerve in cerebral ischemic animal models. To identify proteomic changes in the spinal cord and sciatic nerve in global cerebral ischemic model mice, in the present study we performed an investigation using proteomic methods. In a comparison between the intensity of protein spots obtained from a sham and that from a bilateral carotid artery occulusion (BCAO) in spinal cord and sciatic nerve, the levels of 10 (...
Source: Biological and Pharmaceutical Bulletin - November 4, 2016 Category: Drugs & Pharmacology Authors: Harada S, Matsuura W, Takano M, Tokuyama S Tags: Biol Pharm Bull Source Type: research

Health status correlates of malnutrition in the polish elderly population - Results of the Polsenior Study.
CONCLUSIONS: PNS in Polish elderly population is strongly related to the occurrence of symptoms of depression. People in advanced age with symptoms of depression, cognitive impairment, multimorbidity, anaemia and total edentulism should be screened and monitored for early symptoms of malnutrition. PMID: 27874939 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 24, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Imidazoline I2 receptors: An update
Publication date: Available online 16 March 2017 Source:Pharmacology & Therapeutics Author(s): Jun-Xu Li Since first introduced more than two decades ago, the research in imidazoline I2 receptors has been steadily increasing. This review provides an update on the current status of I2 receptor pharmacology. Imidazoline I2 receptors or I2 binding sites refer to several (at least four) different proteins that bind to [3H]-idazoxan and [3H]-2-BFI with high affinity. The molecular identities of the proteins remain elusive. One of the proteins (45kD) seems to be consistent with the identity of brain creatine kinase. The...
Source: Pharmacology and Therapeutics - March 23, 2017 Category: Drugs & Pharmacology Source Type: research

Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.
Authors: Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P Abstract INTRODUCTION: The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure. Areas covered. Th...
Source: Expert Opinion on Drug Safety - June 2, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

The therapeutic potential of purinergic signalling.
Abstract This review is focused on the pathophysiology and therapeutic potential of purinergic signalling. A wide range of diseases are considered, including those of the central nervous system, skin, kidney, musculoskeletal, liver gut, lower urinary tract, cardiovascular, airways and reproductive systems, the special senses, infection, diabetes and obesity. Several purinergic drugs are already on the market, including P2Y12 receptor antagonists for stroke and thrombosis, P2Y2 receptor agonists for dry eye, A1 receptor agonists for supraventricular tachycardia. Clinical trials are underway for the use of P2X3 rece...
Source: Biochemical Pharmacology - July 20, 2017 Category: Drugs & Pharmacology Authors: Burnstock G Tags: Biochem Pharmacol Source Type: research

Management of amiodarone extravasation with intradermal hyaluronidase.
CONCLUSION: Administration of intradermal hyaluronidase after amiodarone extravasation was associated with decreased expansion of erythema and warmth as well as an improvement in patient-reported pain scores without any noted adverse effects. PMID: 28947526 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - September 29, 2017 Category: Drugs & Pharmacology Authors: Fox AN, Villanueva R, Miller JL Tags: Am J Health Syst Pharm Source Type: research