Filtered By:
Specialty: Neuroscience
Condition: Pain

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 180 results found since Jan 2013.

Neuroscience meets salivary bioscience: An integrative perspective.
Advances in salivary bioscience enable unique opportunities to explore individual differences in biological mechanisms related to learning and memory, psychiatric disorders, and more recently neurodegenerative diseases, neurotrauma/stroke, pain, and sleep. Sampling oral fluid is not only minimally invasive, but specimens can be collected easily and quickly in clinical and field settings. Salivary analytes allow neuroscientists to index endocrine, autonomic, immune, metabolic, and inflammatory processes within close proximity of discrete behavioral, biological, and social events, which is particularly important to advancing...
Source: Behavioral Neuroscience - March 14, 2016 Category: Neuroscience Authors: Segal, Sabrina K. Source Type: research

Multiple faces of protein interacting with C kinase 1 (PICK1): structure, function, and diseases
Publication date: Available online 9 March 2016 Source:Neurochemistry International Author(s): Yun-Hong Li, Nan Zhang, Ya-Nan Wang, Ying Shen, Yin Wang Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin-Rvs (BAR) domain. Through PDZ and BAR domains, PICK1 binds to a large number of membrane proteins and lipid molecules, and is thereby of multiple functions. PICK1 is widely expressed in various tissues, particularly abundant in the brain and testis. In the central nervous system (CNS), PICK...
Source: Neurochemistry International - March 9, 2016 Category: Neuroscience Source Type: research

Neurologic Complications of Commonly Used Drugs in the Hospital Setting
Abstract This chapter reviews the neurologic complications of medications administered in the hospital setting, by class, introducing both common and less common side effects. Detail is devoted to the interaction between pain, analgesia, sedation, and their residual consequences. Antimicrobials are given in nearly every hospital setting, and we review their capacity to produce neurologic sequelae with special devotion to cefepime and the antiviral treatment of human immunodeficiency virus. The management of hemorrhagic stroke has become more complex with the introduction of novel oral anticoagulants, and we provi...
Source: Current Neurology and Neuroscience Reports - February 23, 2016 Category: Neuroscience Source Type: research

The Japanese rTMS experience – Present and future
Fig. 8 coil, which is popular now, was invented by Prof. Ueno in 1988 and spread globally. The rTMS machines were developed in Europe and imported to Japan from 2001 and spread over Japan. The clinical treatments with rTMS have been mainly used for Parkinson’s syndrome, neuropathic pain, depression and rehabilitation after stroke. rTMS of left dorsolateral prefrontal cortex (Neuronetics Inc) for depression is already used in Japanese private clinic, and will be approved by Japanese government in the near future.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: Y. Saitoh, K. Hosomi, H. Nakamura, T. Shimizu Source Type: research

ID 99 – Functional connectivity study on repetitive transcranial magnetic stimulation for central post-stroke pain
This study aimed to investigate functional connectivity specific to CPSP and functional connectivity alteration associated with pain relief by rTMS.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: K. Hosomi, T. Shimizu, T. Maruo, Y. Watanabe, H.M. Khoo, N. Tani, Y. Goto, H. Kishima, T. Yoshimine, Y. Saitoh Source Type: research

ID 100 – Chronic post stroke central pain: Increased success rate of chronic epidural motor cortex stimulation using somatotopic, navigated repetitive TMS for patient selection and implant placement
The outcome at group level of neuromodulation for central pain using stimulation of motor cortices is limited, though for some, there are large effects. Thus, there is a need for selection of patients.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: M. Thordstein, G. Pegenius, K. Gatzinsky Source Type: research

Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α 2 δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity
Abstract The α2δ-1 subunit of the voltage-gated Ca2+ channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic h...
Source: Neuroscience Bulletin - January 19, 2016 Category: Neuroscience Source Type: research

Developments in Varicella Zoster Virus Vasculopathy
Abstract Varicella zoster virus (VZV) is a highly neurotropic human herpesvirus. Primary infection usually causes varicella (chicken pox), after which virus becomes latent in ganglionic neurons along the entire neuraxis. VZV reactivation results in zoster (shingles) which is frequently complicated by chronic pain (postherpetic neuralgia). VZV reactivation also causes meningoencephalitis, myelitis, ocular disorders, and vasculopathy, all of which can occur in the absence of rash. This review focuses on the association of VZV and stroke, and on the widening spectrum of disorders produced by VZV vasculopathy in immu...
Source: Current Neurology and Neuroscience Reports - January 11, 2016 Category: Neuroscience Source Type: research

MMP‐9 in Translation: From Molecule to Brain Physiology, Pathology and Therapy
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 3, 2015 Category: Neuroscience Authors: Behnam Vafadari, Ahmad Salamian, Leszek Kaczmarek Tags: Review Source Type: research

Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats
; Cenk Ayata
Source: Journal of Cerebral Blood Flow and Metabolism - June 30, 2015 Category: Neuroscience Authors: Francesco BlasiFanny HerissonShuxing WangJianren MaoCenk Ayata Tags: central post-stroke pain endothelin-1 hyperalgesia thalamus Source Type: research

Deep brain stimulation for chronic pain
Publication date: Available online 26 June 2015 Source:Journal of Clinical Neuroscience Author(s): Sandra G.J. Boccard , Erlick A.C. Pereira , Tipu Z. Aziz Deep brain stimulation (DBS) is a neurosurgical intervention popularised in movement disorders such as Parkinson’s disease, and also reported to improve symptoms of epilepsy, Tourette’s syndrome, obsessive compulsive disorders and cluster headache. Since the 1950s, DBS has been used as a treatment to relieve intractable pain of several aetiologies including post stroke pain, phantom limb pain, facial pain and brachial plexus avulsion. Several patient series have s...
Source: Journal of Clinical Neuroscience - June 26, 2015 Category: Neuroscience Source Type: research

Parecoxib Protects Mouse Cortical Neurons Against OGD/R Induced Neurotoxicity by Up-Regulating Bcl-2.
In this study, we found parecoxib could protect against neurotoxicity induced by 4 h oxygen-glucose deprivation (OGD) plus reoxgenation for 20 h, a widely used in vitro model of ischemia/reperfusion. In addition, we characterized the molecular mechanism of parecoxib's neuroprotection. We found parecoxib was able to activate CREB, and subsequently maintained the expression of Bcl-2, which is an important mitochondria-associated protein. Inhibition of endogenous Bcl-2 expression by transfection of Bcl-2-shRNA significantly attenuated the neuroprotective effects of parecoxib treatment. Furthermore, ATP production assay and ...
Source: Neurochemical Research - June 2, 2015 Category: Neuroscience Authors: Wang Y, Ma W, Jia A, Guo Q Tags: Neurochem Res Source Type: research

Muscle haematoma due to antithrombotic treatment for ischaemic stroke
Publication date: July 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 7 Author(s): Akiyuki Hiraga , Yoko Nakagawa , Ikuo Kamitsukasa , Takeshi Suzuki , Satoshi Kuwabara The purpose of this study was to evaluate the incidence and clinical features of muscle haematoma in ischaemic stroke patients. Muscle haematomas are rare complications that occur during antithrombotic treatment for acute ischaemic stroke. Clinical and laboratory records of ischaemic stroke patients with muscle haematomas in the last 3.5years were retrospectively reviewed. Muscular haematoma developed in three of 694 (0.4%) consecutive pat...
Source: Journal of Clinical Neuroscience - May 31, 2015 Category: Neuroscience Source Type: research

The Relationship Between Herpes Zoster and Stroke
Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1–2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large ep...
Source: Current Neurology and Neuroscience Reports - February 25, 2015 Category: Neuroscience Source Type: research

Current Evidence in the Management of Poststroke Hemiplegic Shoulder Pain: A Review
ABSTRACT: Hemiplegic shoulder pain is a common, complex, and distressing complication, which is related to stroke and occurs in the paralytic side of the patient. It not only presents in the early stage but also can persist into the chronic stage of stroke. The incidence of this complication varies from 12% to 58%, and the most common period of occurrence is at 8–10 weeks poststroke. The multifactorial etiology and underlying mechanisms make it intractable. It is difficult to get a clear description of the percentage of patients receiving adequate pain relief because of a large number of treatments and different results ...
Source: Journal of Neuroscience Nursing - January 13, 2015 Category: Neuroscience Tags: Article Source Type: research